Disease ⇒ Osteoporosis {40000118} Record Keys Type:Disease Parent:[ ] Definition:Osteoporosis Details Initialisation date:2020-09-06 Other Terms:[ ] LinksWickipediaMerck Manual Meta Information MedDra ID:10031282 MedDra Level:pt ICD:[ ] Category:Musculoskeletal, Rheumatology Zone:[ ] Mechanism:[ ] Notes: - Warmth enhances bacterial polyamine biosynthesis, resulting in higher total polyamine levels in vivo. Spermine and spermidine supplementation increases bone strength, while inhibiting polyamine biosynthesis in vivo limits the beneficial warmth effects on the bone. (1) Shared Reference Notes [1.1] - Gut microbiome is a communicable regulator of bone structure and turnover in mice. - Acquisition of a specific bacterial strain, segmented filamentous bacteria (SFB), a gut microbe that induces intestinal Th17 cell expansion, was sufficient to negatively impact skeletal maturation. [1.2] - #Antibiotic Therapy with Broad-spectrum beta-lactam, amoxicillin > greater abundance of #oxalate-degradation genes present in the gut microbiome post-antibiotic treatment > A reduction in levels of #oxalate, a major calcium-binding anion in the intestinal lumen > facilitate a greater availability and absorption of calcium from the intestines > enhancing bone mineralisation > increase in Bone Mineral Density [1.3] [#Postmenopausal osteoporosis] - In PMO. Considering the positive association between #Devriesia and Bone Material Density, and the negative association between #Montagnulaceae and BMD, the two #Fungi species may play the beneficial and harmful roles during osteoporosis, respectively. [1.4] [#humanized Galactooligosaccharides] - the prebiotic galactooligosaccharides (GOS) promotes the growth of #Bifidobacteria which increases calcium absorption and prevents bone loss and enhances calcium absorption and inhibits bone resorption in #Postmenopausal women - #Serotonin levels could predict an increased risk for osteoporotic fractures, gut-derived #Serotonin reduces osteoblast proliferation and inhibits bone formation leading to a decrease in BMD and a higher risk of osteoporosis [#Short Chain Fatty Acid] - Gut microbiota modulates host IGF-1 levels through the production of SCFAs. - the serum level of IGF-1 has been correlated with the abundance of cecal SCFAs. T - IGF-1 binds the IGF receptor present in osteoblast/osteoclast resulting in stimulating bone [1.5] - treatment of gonadal-intact mice with pasteurized #Akkermansia resulted to a reduction in trabecular and cortical bone mass - that greater abundances of the genera; #Akkermansia and #DTU089, were associated with lower radius total vBMD, and tibia cortical vBMD respectively. - genera #DTU089, a #Clostridiales bacterium, was generally associated with lower bone density consistently in both of the two cohorts. - #DTU089 is associated with lower protein intake - higher abundances of #Lachnospiraceae NK4A136 group, and #Faecalibacterium were associated with greater tibia cortical vBMD - mouse studies have implicated a disorder of #Purine metabolism to osteoporosis [1.6] [#Postmenopausal osteoporosis] [#Bacteroides vulgatus] - several individual bacterial species (especially B. vulgatus) were significantly associated with bone mineral density (BMD) in ethnically distinct populations. - serum VA levels were positively associated with L1-L4 BMD; - B. vulgatus was negatively associated with serum VA levels and may causally suppress VA levels, presumably by inhibiting growth of VA-producing bacteria within the gut. - Serum #Valeric acid (VA), a microbiota derived metabolite, was positively associated with BMD and causally downregulated by B. vulgatus. - Ovariectomized mice fed B. vulgatus demonstrated increased bone resorption and poorer bone micro-structure, while those fed VA demonstrated reduced bone resorption and better bone micro-structure. - NO effect of B. vulgatus on the sham-operated groups of mice, which indicates that the B. vulgatus may have distinct effects in eugonadic mice and estrogen deficient mice. [1.7] [#Limosilactobacillus (Lactobacillus) reuteri] [#Probiotic] - L. reuteri > Could reduce bone loss associated with estrogen deficiency in an ovariectomized (Ovx) mouse menopausal model. - Osteoclast bone resorption markers and activators (Trap5 and RANKL) as well as osteoclastogenesis are significantly decreased in L. reuteri-treated mice. - L. reuteri treatment may be a straightforward and cost-effective approach to reduce post-menopausal bone loss. [1.8] - A peptide from the von Willebrand factor type A domain protein (vWFA) was the most potent activator of Ro60-reactive T cells.References Notes[ ]
