Disease ⇒ Collagen-induced arthritis {40000654} Record Keys Type:Disease Parent:[ ] Definition:Collagen-induced arthritis Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Reactive arthritis] - IAA, #5-Hydroxytryptophan (5-HTP), and 5-HIAA ameliorate arthritis severity in proteoglycan-induced #Spondyloarthritis. CIA, and antigen-induced arthritis, respectively. [#Rheumatoid Arthritis, #Spondyloarthritis] [#Lachnospiraceae bacterium] - in CIA (such as Lachnospiraciae and Lactobacillaeae), RA (#Lachnospiraceae bacterium, #Lactobacillus spp., #Faecalibacterium), and SpA (#Ruminococcaceae, #Rikenellaceae, #Porphyromonadaceae, #Bacteroidaceae, #Lachnospiraceae) are either predicted or known to produce #Indole [#Rheumatoid Arthritis] - #kynurenine supplementation, or inhibition of #kynurenine production with the IDO1 inhibitor 1-methyl-#Tryptophan (1-MT) have shown conflicting effects on arthritis severity: - #Indole supplementation appears to affect several aspects of CIA pathophysiology, including the induction of proinflammatory cytokines, CD4+ T cell skewing toward Th17 cells, and antibody-mediated complement activation.References Notes[ ]
