Disease ⇒ Anxiety {40000113}

Shared Notes

• [1.1] 
  - Stress and anxiety are related to gut dysbiosis.
  - Ingesting Lactobacillus plantarum P-8 (P-8) improved stress/anxiety symptoms.
  - Symptoms were relieved by modulating gut microbiota and neuroactive potential.
• [1.5] 
  - Combination of probiotics and polyphenol-rich prebiotics, a synbiotic >attenuates the chronic-stress induced inflammatory responses in the ileum and the prefrontal cortex promoting > resilience to the consequent depressive- and anxiety-like behaviors in male mice.
  - This effect may be attributed to specific synbiotic-produced metabolites including 4-hydroxyphenylpropionic, 4-hydroxyphenylacetic acid and caffeic acid > promoted anti-inflammatory activity through the aryl hydrocarbon receptor (AHR).
• [1.2] 
  - Lactobacillus reuteri and Bifidobacterium adolescentis Probitica > reduction in depressive symptoms at four and eight weeks of treatment, and anxiety symptoms at four weeks.
  > improvement in sleep quality.
  - Lactobacillus reuteri and Bifidobacterium adolescentis Probitica > decrease in serum interleukin-6 levels.
  - Lactobacillus reuteri and Bifidobacterium adolescentis Probitica > increased Bifidobacteriaceae and Lactobacillacea, whereas it decreased Enterobacteriaceae in the gut microbiota composition.
• [1.3] 
  - mice exposed to 4EPS displayed anxiety-like behaviours, and pharmacological treatments that promote oligodendrocyte differentiation prevented the behavioural effects of 4EPS.