Disease ⇒ Anxiety {40000113}

Shared Reference Notes

• [1.1] 
  - Stress and anxiety are related to gut dysbiosis. - Ingesting Lactobacillus plantarum P-8 (P-8) improved stress/anxiety symptoms. - Symptoms were relieved by modulating gut microbiota and neuroactive potential.
• [1.2] [#Depression] 
  - #Combination of probiotics and polyphenol-rich prebiotics, a synbiotic >attenuates the chronic-stress induced inflammatory responses in the ileum and the prefrontal cortex promoting > resilience to the consequent depressive- and anxiety-like behaviors in male mice. - This effect may be attributed to specific synbiotic-produced metabolites including #4-hydroxyphenylpropionic, #4-hydroxyphenylacetic acid and #Caffeic acid > promoted anti-inflammatory activity through the aryl hydrocarbon receptor (AHR).
• [1.3] [#Depression] [#Lactobacillaceae, #Limosilactobacillus (Lactobacillus) reuteri] [#Probiotic (Bifidobacter and Lactobacilus)] 
  - Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > reduction in depressive symptoms at four and eight weeks of treatment, and anxiety symptoms at four weeks. > improvement in #Sleep quality. - Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > decrease in serum interleukin-6 levels. - Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > increased #Bifidobacteriaceae and Lactobacillacea, whereas it decreased #Enterobacteriaceae in the gut microbiota composition.
• [1.4] [#BDNF] 
• [1.5] 
  - mice exposed to #4EPS displayed anxiety-like behaviours, and pharmacological treatments that promote oligodendrocyte differentiation prevented the behavioural effects of #4EPS.
• [1.6] [#Generalized anxiety disorder] 
• [1.7] 
  - #Subdoligranulum and #Coprococcus were consistently found to be depleted in individuals with generalized anxiety disorder and #Depression
• - #Eggerthella has been consistently found to be increased in #Depression and anxiety cases.
• [1.8] [#Bifidobacterium longum, #Lactobacillus helveticus] 
  - consum of a mix of psychobiotics (L. helveticus and B. longum) exhibited less anxiety and #Depression than controls.
• [#Lactobacillus rhamnosus] - in pregnant women, supplementation with L. rhamnosus HN001 lead to significantly less postpartum #Depression and anxiety
• [#Epigallocatechin gallate] - a #Pomegranate extract was shown to reduce microgliosis and #Amyloid-beta plaque deposition in association with reduced anxiety-like behavior and increased memory performance. - This effect was attributed to two polyphenolic compounds, #Punicalagin and #Ellagic acid, and likely its bioactive microbial-derived metabolite EGCG
• - germ-free mice have reduced anxiety compared to specific pathogen free mice, which is correlated to reduced brain-derived neurotrophic factor (#BDNF) expression in the amygdala.

References Notes