Phenylacetic acid {90000369} Record Keys Parent:[ ] Definition:Phenylacetic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Atherosclerosis, #CVD] - gut microbiota-dependent metabolism of dietary #Phenylalanine into phenylacetic acid (PAA) is critical in #Phenylacetylglutamine (PAGln) production, a metabolite linked to atherosclerotic cardiovascular disease (ASCVD). - PPFOR is the main contributor for PAA production in #Bacteroides thetaiotaomicron. - PPDC plays an important role in PAA generation in #Proteus mirabilis. - PPFOR and PPDC contribute to PAA production and PAGln formation in colonized hosts. - Gut microbial ppdc and ppfor homolog abundances are each associated with ASCVD in humans. [1.2] - #Grape seed > the growth of #Lactobacillus and #Enterococcus spp. were elevated. - These changes in the gut microbiota were associated with increases in #4-hydroxyphenylacetic acid, #Phenylpropionic acid, phenylacetic acid and #4-hydroxybenzoic acid [1.3] [#Crohn’s disease] - Administration of PAGly exacerbated #Colitis in mouse model and upregulated coagulation-related biological processes. - High dietary protein intake and increased abundance of phenylacetic acid (PAA)-producing #Proteobacteria mediated by phenylpyruvate decarboxylase act in concert to cause the elevated PAGln levels in CD patients. [1.4] [#Clostridium sporogenes] - C sporogenes, can convert dietary protein derived #Phenylalanine to phenylacetic acid, which is then converted by liver enzymes to #Phenylacetylglutamine, a metabolite linked with #Hypertension and increased risk of #Stroke.References Notes[ ]
