ZO-1 {90000589} Record Keys Parent:[ ] Definition:ZO-1 Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - sodium #Butyrate (NaB) inhibits NF-κB activation and restores the production of tight junction proteins ZO-1 and #Claudin-1 to block the vicious cycle of cytokine storms, improve intestinal barrier function, and increase the survival rate. [1.2] [#Fiber-free diet, #Low fibre Diet] - the lowest levels of tight junction proteins ZO-1 and #Occludin in TG mice challenged by fiber deprivation and #Curli. [#Parkinson’s Disease] - In intestinal biopsies from patients with PD, especially #Occludin was found at lower levels, whereas ZO-1 was unchanged. [1.3] [#Exercise training] - Exercise increased the expression of #BDNF and decreased expression of Zo-1 and Claudin5 in the brain. [1.4] - reduction of membrane localization of tight junction protein (ZO-1, ZO-2, #Occludin, #Claudin-1, and -3) and increased permeability in colonocytes were induced by the #Ammonia treatment > mitochondrial dysfunction > increase of #Oxidative stress, > intestinal barrier dysfunction. [1.5] [#Lactobacillus plantarum] - treatment with #Lactobacillus plantarum L137 increased the abundance of #Lactobacillus species, improved intestinal barrier integrity via upregulation of ZO-1, as well as modulated cytokine levels. - In #Colitis mice, treatment with #Lactobacillus plantarum L137 ameliorated disease-associated changes and exhibited an anti-inflammatory effect. References Notes[ ]
