IL-10 {90000494}

Shared Reference Notes

• [1.1] [#Acute lymphoblastic leukemia] 
  - #Children who develop ALL have reduced levels of IL-10 and enhanced pro-inflammatory signatures at birth, which in turn have been linked to impaired B cell development and increased B cell DNA damage in mouse models of childhood ALL
• [1.2] [#Celiac Disease] 
  - #Bacillus subtilis LZU-GM was isolated from Pakistani traditional fermented sourdough and could degrade 73.7% of #Gluten in 24 h in vitro. - The #Gluten degradation was 3-fold higher in the small intestine of the strain LZU-GM treated mice group. - #Gluten-treated mice established positive antigliadin antibodies (AGA) in serum (IgA, IgG, and anti-TG2 antibodies) as compared to the strain LZU-GM treatment group. - the number of IFN-γ, TNF-α, IL-10, and COX-2 cells decrease in the lamina propria of the strain LZU-GM treatment group. - Microbial community bar plot analysis showed that #Lactobacillus, #Dubosiella, and #Enterococcus genera were restored and stabilized in the LZU-GM treatment group while #Blautia and #Ruminococcus were found lower.
• [1.3] [#Depression] [#TNF-alfa] 
  - #Lipopolysaccharide (LPS) produced by #Veillonella could stimulate the release of TNF-α, IL-1, #IL-6 and IL-10 within Toll-like receptor (TLR) pathways
• [#Serum CRP] - As a #Butyrate-producing bacteria, #Butyricicoccus was positively correlated with anti-inflammatory cytokines such as IL-4, IL-10, and IL-11. - The negative association between CRP and #Butyricicoccus abundance may reflect an imbalance between pro- and anti- inflammatory reactions.
• [1.4] [#Systemic lupus erythematosus] 
  - #Lactobacillus treatment decreased #IL-6 and increased IL-10 production in the gut contributing to an anti-inflammatory environment.
• [1.5] [#Autism] [#Bifidobacterium animalis, #Lactobacillus acidophilus, #Lactobacillus plantarum, #Streptococcus thermophilus] 
  - Sptreptococcus thermophilus, #Bifidobacterium breve, B. animalis, #Lactobacillus helveticus, L. plantarum, L. acidophilus, and L. paracacei > attenuated the inflammatory responses in a VPA-induced rodent ASD model. - psychobiotic treatment decreased serum pro-inflammatory cytokine, #IL-6 levels, and increased anti-inflammatory cytokine, IL-10 levels, with the improved status of diverse behavior tests including social interaction, #Anxiety, and repetitive behaviors
• [#TNF-alfa] - anti-inflammatory cytokines (IL-4 and IL-10) and proinflammatory cytokines (TNF-a, #IL-1b, #IL-2, #IL-6, #IL-8, #IL-12, #IL-17, and #IL-18) are significantly changed by #Lactobacillus rhamnosus GG (LGG)
• [1.6] [#humanized Galactooligosaccharides] 
  - GOS increased the blood level of interleukin 8 (#IL-8), interleukin 10 (IL-10), and #C-reactive protein in adults, but decreased IL-1β. It has been found that the function of NK cells improves by consuming GOS.
• [1.7] [#Short Chain Fatty Acid] 
  - SCFAs trigger the generation of #Prostaglandin E2 and the IL-10 levels by stimulating GPCRs, and can also activate inflammasomes, promoting the production and secretion of #IL-18.
• [1.8] 
  - #Enterococcus faecalis is capable of modulating immune function by suppressing macrophage activity through preventing NF-κB signaling or promoting anti-inflammatory cytokine IL-10
• [1.9] 
  - IL-10 production was significantly higher in the mice kept on an #Isoflavone diet suggesting an immunoregulatory effect.
• [#Antimicrobial peptides] - AMPs produced by #Lactobacillus plantarum were capable of modulating cytokine production in PBMCs, with an increase in the production of the anti-inflammatory cytokines IL-10 and #IL-12 by over 10-fold.
• [1.11] 
  - T-cells stimulated with #Staphylococci become Th1-type cells; however, this differentiation is mitigated in #Bifidobacterium-stimulated T-cells. - prestimulation of T-cells with #Bifidobacterium suppresses the activation of #Staphylococcus-specific T-helper cells in a cell-cell dependent manner by inducing FoxP3+CD4+ T-cells, increasing IL-10 and galectin-1 secretion and showing a CTLA-4-dependent inhibitory capacity.
• [1.12] 
  - #Bacteroides fragilis, a typical constituent of the gut microbiota, drives the differentiation of IL-10-secreting Treg cells by signaling via its capsular #Polysaccharide.
• [1.13] [#Bacteroides fragilis] 
  - B. fragilis has the ability to induce the phagocytes of the lamina propria to produce the anti-inflammatory cytokine IL-10, thereby activating Treg and increasing immune regulation
• - #Lactobacillus casei can increase anti-inflammatory cytokines (such as IL-10, TGF-β) and inhibit pro-inflammatory cytokines (such as IL-1β, #IL-2) - #Lactobacillus casei can promote the differentiation of CD4+ T cells into Treg and inhibit their differentiation into Th17 cells, thereby regulating immune function
• [1.14] 
  - #Resveratrol and #Resveratrol-related PCs (e.g. pterostilbene) have further demonstrated to alleviate intestinal inflammation in mice with #Colitis by regulating the Th17/Treg balance and control the levels of plasmatic and intestinal mucosal cytokines such as transforming growth factor beta (TGF-β), #IL-6, IL-10 and #IL-17, restoring the percentage of CD4+ T cells in mesenteric lymph nodes (MLNs) and decrease their number in the intestinal LP, as well as reducing the percentage of macrophages in both regions
• [1.15] [#Allergic rhinitis] 
  - butyrylated #Starch significantly increased the levels of colonic #Butyrate, and downregulated serum OVA-sIgE, IL-4, and IL-5, and improved symptoms in AR mice. In addition, the proportion of Treg cells in mesenteric lymph nodes and the levels of IL-10 and TGF-β in the serum were elevated after butyrylated #Starch intervention. - butyrylated #Starch promoted the enrichment of beneficial genera in AR mice, such as #Lactobacillus, and alleviated the composition and structural disorder of gut microbiota in AR mice.

References Notes