Lachnospiraceae ⇒ Lachnospira {10000584}

Shared Reference Notes

• [1.1] [#Diabetes Type 2] 
  - Lachnospira contribute to diabetes in obese mice and is enriched in obese children
• [1.2] [#Diabetes Type 2] 
  - A reduction in the Lachnospira, #Roseburia, #Faecalibacterium and #Coprococcus genera in the T2D group. - These genera were #Butyrate producers. - The decrease of these genera favored #Obesity and the development of diseases.
• [1.3] 
  - Lachnospira was the only bacterial species which had a reduced population in the neurodegenerative diseased state but had a high PS for #Butyrate formation.
• [1.4] [#Short Chain Fatty Acid] [#Exercise training] 
  - A six-week moderate to intense aerobic exercise (30–60 min) program can induce a shift in the SCFA-producing #Faecalibacterium and Lachnospira spp. and genetic machinery (BCoATe) substantially in lean versus obese participants.
• [1.5] [#Antibiotic Therapy] 
  - Postnatal antibiotic exposure > reduced relative abundance of #Lachnospiraceae (for example, #Dialister spp. and Lachnospira spp.) and #Ruminococcaceae and increased relative abundance of #Veillonella.
• [1.6] [#Obesity] [#Collinsella aerofaciens] 
  - subjects with BMI values ≥25 kg/m2 have higher relative abundances of members of the #Collinsella genus (e.g., #Collinsella aerofaciens), and the #Veillonellaceae and #Lachnospiraceae families (e.g., genera #Dorea, Lachnospira, #Coprococcus).
• [1.7] [#Parkinson’s Disease] [#Short Chain Fatty Acid] 
  - depletion of SCFA-producing bacteria (e.g., Lachnospira and #Butyricicoccus), has already occurred at prodromal PD (RBD and RBD-FDR).
• [1.8] [#Systemic lupus erythematosus] 
  - #Actinobacteria, #Bacillales, #Coprobacter and Lachnospira were inversely correlated with the risk of SLE, and #Bacilli, Eggertella and #Lactobacillales might be the risk factors of SLE.
• [1.9] [#Almond] 
  - almonds (dose of 42 g/day) > increase in the relative amount of Lachnospira, #Roseburia, and #Dialister
• [#Prostate cancer] [#Short Chain Fatty Acid] - #Subdoligranulum, #Lachnobacterium, #Christensenellaceae, Lachnospira, #Rikenellaceae, #Eggerthella, and #Alistipes are members of the SCFA-producing order #Clostridiales and were shown to be more prevalent in individuals with high-grade PCA.
• [1.11] [#Attention Deficit Hyperactivity Disorder] 
  - higher abundance of three genera (#Agathobacter, #Anaerostipes, and Lachnospira) and decreased levels of TNF-α in the ADHD
• [1.12] [#Juvenile idiopathic arthritis] [#Roseburia hominis] 
  - In JIA > reduced #Anaerostipes, #Dialister, Lachnospira, and #Roseburia have been correlated with rheumatic clinical indices including antibodies, erythrocyte sedimentation rate (ESR) and clinical JIA disease activity score. - #Dialister, Lachnospira, and #Roseburia (#Roseburia hominis in 0% of ABISJIA) were three of five genera reduced in ABISJIA, as well as an ASV belonging to #Anaerostipes.
• [1.13] [#Exercise training] 
  - Abundance of #Lachnospiraceae (#Roseburia and Lachnospira) has been positively correlated with VO2max and fecal #Butyrate after 2 weeks of high-intensity interval training.
• [1.14] [#mRNA vaccine] 
  - Certain #Butyrate producers, such as Lachnospira, #Catenibacterium, and #Faecalibacterium, were enriched in individuals with higher immunogenic responses to the BNT162b2 vaccine
• [#Covid-19] [#mRNA vaccine] - #Agathobacter, #Lactobacillus, #Bacteroides, and Lachnospira were positively correlated with both spike IgG levels and spike-specific CD4+ T-cell responses. These #Bacteria with known immunomodulatory properties could contribute to higher immune responses to vaccinations
• [1.15] [#COPD Exacerbation] 
  - In COPD > the relative abundance of Lachnospira and #Coprococcus was negatively related to the #Smoking index and positively related to lung function results. - The relative abundance of #Parabacteroides was positively correlated with the #Smoking index and negatively correlated with lung function findings.
• [1.16] [#Cushing’s disease] 
  - #Collinsella, a genus form of the #Actinobacteria phylum was present in CD patients only, whereas #Sutterella, a genus from #Proteobacteria phylum, was scarcely detectable/undetectable in CD patients as well as Lachnospira, a genus of the #Lachnospiraceae family of the #Firmicutes phylum.

References Notes