Glutamate {60000109}
Parent: | [ ] |
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Definition: | Glutamate |
Queue: | [ ] |
Initialisation date: | 2020-10-18 |
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Specification: | |
- Precursor for the neurotransmitter GABA | |
Source: | |
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Structural Type: | Amino acid |
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Functional Type: | Neurotransmitter |
Function: | Neurodevelopment |
Notes:
- Excessive glutamate consumption > positively correlated with overweight.
Shared Reference Notes
- [1.1]
- #5-methyltetrahydrofolic acid, #Alanine, glutamate and #Selenium > influence #Proteobacteria. - [1.2]
- Elevated levels of #Glutamine and γ-aminobutyric acid (#GABA) and reduced glutamate were observed in the hippocampus of germ-free mice that received fecal transplants from schizophrenic mice and showed #Schizophrenia-like behaviors. - [1.3] [#Celiac Disease, #Migraine] [#CGRP, #Serotonin]
- [1.4] [#Autism]
- The depletion of #Bifidobacterium species has been reported widely in ASD. - #Bifidobacteria are SCFA producers, and “psychobiotics” , and they modulate the gut–brain signals via γ-aminobutyric acid (GABA) and glutamate metabolism. - #Bifidobacterium have been reported to improve behavior and prevent #Depression-like behaviors in mice. - [1.5] [#Parkinson’s Disease]
- In the PD metagenome, we noted a decrease in glutamate/glutamine synthesis gene-families and pathways, and a concomitant increase in both glutamate and #GABA degradation. - [1.6] [#Depression]
- Glutamate levels in plasma, serum, cerebrospinal fluid and brain tissue have been associated with mood and psychotic disorders and suicide.
References Notes
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