Disease ⇒ Cancer ⇒ Oral cancer {40000278}

Shared Reference Notes

• [1.1] [#Colorectal cancer, #Thyroid carcinoma] [#Hydrogen sulfide] 
  - H2S at a safe and nontoxic concentration can protect not only healthy cells, such as neurons, but also cancerous cells from apoptosis. - In a variety of cancers, including #Ovarian cancer, oral cancer, thyroid cancer, colon cancer, #Breast cancer, etc., the upregulation of H2S-producing enzyme CBS > can enhance the proliferation ability of cancer cells and make cancer cells more sensitive to it
• [1.2] 
  - #Parvimonas micra, #Haemophilus influenzae, #Fusobacterium periodonticum, #Streptococcus constellatus, and #Filifactor alocis progressively increased with oral cancer development.
• - The abundance of dominant genera such as #Fusobacteria increased with cancer development, the abundance of Haemophilus, Streptococcus, Actinomyces, and Porphyromonas decreased.
• [#Porphyromonas gingivalis] - P. gingivalis, a critical pathogen in periodontal disease, is a significant trigger agent for oral cancer, and its colonization in tumor tissues is correlated with poor survival in patients with carcinoma
• [1.3] [#Esophageal cancer, #Head & Neck cancer] 
  - Among streptococci, #Streptococcus anginosus seems to be an especially relevant marker of head, neck, and esophageal cancers
• [#Streptococcus constellatus, #Streptococcus mitis, #Streptococcus oralis, #Streptococcus salivarius, #Streptococcus sanguis] - oral #Streptococci (#Streptococcus intermedius, S. constellatus, S. oralis, S. mitis, S. sanguis, S. salivarius) were the most common isolates from cervical lymph nodes in patients with oral cancer. - Among the anaerobic bacteria, #Peptostreptococcus spp. dominated
• [1.4] [#Oral squamous cell carcinoma] 
  - the genera #Parvimonas, #Peptoniphilus and #Fusobacterium were most abundant in an oral cancer subtype, OSCC
• [1.5] [#Crohn’s disease, #Inflamatory bowel disease, #Ulcerative Colitis] 
  - CD and UC, as subtypes of IBD, were also found to be potential risk factors for oral cavity cancer
• [1.6] 
  - the proportion of #Prevotella in oral cancer tissue was larger than that in normal tissue
• [1.7] [#Cancer, #Head & Neck cancer] [#Alcohol Consumption] 
  - alcohol dehydrogenase enzyme found in different #Candida species enables them to produce #Acetaldehyde that is highly toxic, mutagenic, and carcinogenic
• - The mitochondrial toxicity of acrebol produced by #Acremonium exuviarum.
• [#Aspergillus fumigatus] - The ability of A. fumigatus to generate #Reactive Oxygen Species linked to oral cancer
• - #Candida has pronounced nitrosation potential due to the production of #Nitrosamine compounds that have a significant role in oral carcinogenesis
• - #Rhodotorula, #Geotrichum, and #Pneumocystis were exclusively found in specimens collected from cancer patients, while #Fonsecaea was absent in oral tissues from healthy participants. - #Fonsecaea was present in cancer samples and tissues adjacent to malignancy from the same patients.
• - the only fungal species in tumor samples experiencing a significant decrease in matching non-tumor tissues was #Glomeromycota

References Notes