Short peptide bacteriocins {90000482} Record Keys Parent:[ ] Definition:Short peptide bacteriocins Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Clostridioides difficile] - SPB of class RiPP- sactibitoic called thuricin CD, which showed potent inhibition of Clostridium difficile without affecting the commensal gut microbiome - #Lactocillin, a thiopeptide SPB isolated from a vaginal commensal #Lactobacillus was shown to inhibit several pathogens colonising skin or vagina and showed no antimicrobial activity against other #Lactobacilli species [1.2] - #Subtilosin A, an SPB produced by #Bacillus subtilis, which is capable of exerting strong inhibitory activity against #Streptococcus pyogenes at a very low concentration (1.25 µg/mL), but against #Streptococcus gordonii had an MIC value of 83.25 µg/mL [#Cutibacterium acnes] - C. acnes is responsible for the production of the SPB #Cutimycin, a peptide which is capable of inhibiting #Staphylococcus species growth. [#Normal Vaginal condition] - SPB #Lactocillin, a peptide isolated from the vaginal commensal microorganism #Lactobacillus johnsonii PF01, which has showed the capacity to inhibit pathogens from colonizing the skin [#Staphylococcus aureus, #Staphylococcus hominis] - SPB from S. hominis which was capable of inhibiting S. aureus quorum sensing and limited S. aureus-mediated epidermal proteolysis and inflammatory response - SPB obtained from #Staphylococcus simulans was capable of reducing MRSA-related dermonecrotic and epicutaneous skin lesions in mouse models.References Notes[ ]
