Disease ⇒ Chronic Obstructive Pulmonary Disease {40000195}
Type: | Disease |
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Parent: | [ ] |
Definition: | Chronic Obstructive Pulmonary Disease |
Initialisation date: | 2021-02-09 |
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Other Terms: | COPD |
MedDra ID: | 10009033 |
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MedDra Level: | pt |
ICD: | [ ] |
Category: | [ ] |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
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Shared Reference Notes
- [1.1]
- Lung microbiota differences may contribute to airway dysfunction and airway disease in milder COPD particularly by the dysbiosis of the members of the Streptococcus, Prevotella, Veillonella, Staphylococcus, and Pseudomonas genera. - [1.2]
- The oral and pulmonary mycobiomes from controls and participants with COPD were dominated by #Candida - Malassezia and Sarocladium were also frequently found in pulmonary samples. - [1.3]
- [1.4] [#Smoking]
- [1.5] [#Bufei Jianpi formula]
- BJF administration > increased the abundance of Firmicutes and the ratio of Firmicutes to Bacteroides, raising SCFA levels, including acetate, butyrate, and propionate levels. - However, the abundance of Bacteroidetes, Proteobacteria, Spirochaetes, Clostridiaceae, and Treponema decreased. - BJF decreased the gene and protein expression of NLRP3, Caspase-1, IL-8, and IL-1β, and increased GPR43 expression. - [1.6] [#Cystic fibrosis exacerbation, #non-cystic fibrosis bronchiectasis]
- [1.7]
- In Neutrophil-predominant COPD altered #Tryptophan metabolism in airway #Lactobacilli is associated with reduced #Indole-3-acetic acid (IAA), which was in turn linked to perturbed host interleukin-22 signalling and epithelial cell apoptosis pathways. - airway microbiome-derived IAA mitigates neutrophilic inflammation, apoptosis, emphysema and lung function decline, via macrophage–epithelial cell cross-talk mediated by interleukin-22. - Intranasal inoculation of two airway #Lactobacilli restored IAA and recapitulated its protective effects in mice. - [1.8]
References Notes
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