Microbiome & Chronic Diseases

Evidence Based Medicine
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Disease ⇒ Chronic Obstructive Pulmonary Disease {40000195}

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Chronic Obstructive Pulmonary Disease


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Shared Reference Notes

  • [1.1
    - Lung microbiota differences may contribute to airway dysfunction and airway disease in milder COPD particularly by the dysbiosis of the members of the Streptococcus, Prevotella, Veillonella, Staphylococcus, and Pseudomonas genera.
  • [1.2
    - The oral and pulmonary mycobiomes from controls and participants with COPD were dominated by #Candida - Malassezia and Sarocladium were also frequently found in pulmonary samples.
  • [1.3
  • [1.4] [#Smoking
  • [1.5] [#Bufei Jianpi formula
    - BJF administration > increased the abundance of Firmicutes and the ratio of Firmicutes to Bacteroides, raising SCFA levels, including acetate, butyrate, and propionate levels. - However, the abundance of Bacteroidetes, Proteobacteria, Spirochaetes, Clostridiaceae, and Treponema decreased. - BJF decreased the gene and protein expression of NLRP3, Caspase-1, IL-8, and IL-1β, and increased GPR43 expression.
  • [1.6] [#Cystic fibrosis exacerbation, #non-cystic fibrosis bronchiectasis
  • [1.7
    - In Neutrophil-predominant COPD altered #Tryptophan metabolism in airway #Lactobacilli is associated with reduced #Indole-3-acetic acid (IAA), which was in turn linked to perturbed host interleukin-22 signalling and epithelial cell apoptosis pathways. - airway microbiome-derived IAA mitigates neutrophilic inflammation, apoptosis, emphysema and lung function decline, via macrophage–epithelial cell cross-talk mediated by interleukin-22. - Intranasal inoculation of two airway #Lactobacilli restored IAA and recapitulated its protective effects in mice.
  • [1.8

References Notes

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Common References