Disease ⇒ Chronic Obstructive Pulmonary Disease {40000195} Record Keys Type:Disease Parent:[ ] Definition:Chronic Obstructive Pulmonary Disease Details Initialisation date:2021-02-09 Other Terms:COPD Meta Information MedDra ID:10009033 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - Lung microbiota differences may contribute to airway dysfunction and airway disease in milder COPD particularly by the dysbiosis of the members of the Streptococcus, Prevotella, Veillonella, Staphylococcus, and Pseudomonas genera. [1.2] - The oral and pulmonary mycobiomes from controls and participants with COPD were dominated by #Candida - Malassezia and Sarocladium were also frequently found in pulmonary samples. [1.3] [1.4] [#Smoking] [1.5] [#Bufei Jianpi formula] - BJF administration > increased the abundance of Firmicutes and the ratio of Firmicutes to Bacteroides, raising SCFA levels, including acetate, butyrate, and propionate levels. - However, the abundance of Bacteroidetes, Proteobacteria, Spirochaetes, Clostridiaceae, and Treponema decreased. - BJF decreased the gene and protein expression of NLRP3, Caspase-1, IL-8, and IL-1β, and increased GPR43 expression. [1.6] [#Cystic fibrosis exacerbation, #non-cystic fibrosis bronchiectasis] [1.7] - In Neutrophil-predominant COPD altered #Tryptophan metabolism in airway #Lactobacilli is associated with reduced #Indole-3-acetic acid (IAA), which was in turn linked to perturbed host interleukin-22 signalling and epithelial cell apoptosis pathways. - airway microbiome-derived IAA mitigates neutrophilic inflammation, apoptosis, emphysema and lung function decline, via macrophage–epithelial cell cross-talk mediated by interleukin-22. - Intranasal inoculation of two airway #Lactobacilli restored IAA and recapitulated its protective effects in mice. [1.8] References Notes[ ]
