Disease ⇒ Chronic Obstructive Pulmonary Disease {40000195}

Record Keys
Type:	Disease
Parent:	[ ]
Definition:	Chronic Obstructive Pulmonary Disease

Details
Initialisation date:	2021-02-09
Other Terms:	COPD

Meta Information
MedDra ID:	10009033
MedDra Level:	pt
ICD:	[ ]
Category:	[ ]
Zone:	[ ]
Mechanism:	[ ]

Notes:

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Shared Reference Notes

[1.1]
- Lung microbiota differences may contribute to airway dysfunction and airway disease in milder COPD particularly by the dysbiosis of the members of the Streptococcus, Prevotella, Veillonella, Staphylococcus, and Pseudomonas genera.
[1.2]
- The oral and pulmonary mycobiomes from controls and participants with COPD were dominated by #Candida - Malassezia and Sarocladium were also frequently found in pulmonary samples.
[1.3]
[1.4] [#Smoking]
[1.5] [#Bufei Jianpi formula]
- BJF administration > increased the abundance of Firmicutes and the ratio of Firmicutes to Bacteroides, raising SCFA levels, including acetate, butyrate, and propionate levels. - However, the abundance of Bacteroidetes, Proteobacteria, Spirochaetes, Clostridiaceae, and Treponema decreased. - BJF decreased the gene and protein expression of NLRP3, Caspase-1, IL-8, and IL-1β, and increased GPR43 expression.
[1.6] [#Cystic fibrosis exacerbation, #non-cystic fibrosis bronchiectasis]
[1.7] [#Indole-3-acetic acid (IAA)]
- In Neutrophil-predominant COPD altered #Tryptophan metabolism in airway #Lactobacilli is associated with reduced indole-3-acetic acid (IAA), which was in turn linked to perturbed host interleukin-22 signalling and epithelial cell apoptosis pathways. - airway microbiome-derived IAA mitigates neutrophilic inflammation, apoptosis, emphysema and lung function decline, via macrophage–epithelial cell cross-talk mediated by interleukin-22. - Intranasal inoculation of two airway #Lactobacilli restored IAA and recapitulated its protective effects in mice.

References Notes

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↥ Microbiota

‐ Abiotrophia Bronchoalveolar lavage Human [1.8]
‐ Actinomyces Bronchoalveolar lavage Human [1.8]
‐ Aeromonas Bronchoalveolar lavage Human [1.8]
‐ Afipia Bronchoalveolar lavage Human [1.9]
‐ Anaerosporobacter Bronchoalveolar lavage Human [1.8]
‐ Atopobium Bronchoalveolar lavage Human [1.8]
‐ Balneimonas Bronchoalveolar lavage Human [1.8]
‐ Bifidobacterium Bronchoalveolar lavage Human [1.8]
‐ Brevundimonas Bronchoalveolar lavage Human [1.9]
‐ Bulleidia Bronchoalveolar lavage Human [1.8]
‐ Burkholderia Tissue biopsie Human [1.10]
‐ Butyrivibrio Bronchoalveolar lavage Human [1.8]
‐ Campylobacter Bronchoalveolar lavage Human [1.8]
‐ Capnocytophaga Bronchoalveolar lavage Human [1.9]
‐ Catonella Bronchoalveolar lavage Human [1.8]
‐ Centipeda Bronchoalveolar lavage Human [1.8]
‐ Chryseobacterium Sputum Human [1.11]
‐ Clostridium symbiosum Bronchoalveolar lavage Human [1.12]
‐ Corynebacterium Bronchoalveolar lavage Human [1.9]
‐ Cryptobacterium Bronchoalveolar lavage Human [1.8]
‐ Curvibacter Bronchoalveolar lavage Human [1.9]
‐ Desulfobulbus Bronchoalveolar lavage Human [1.8]
‐ Dialister Bronchoalveolar lavage Human [1.8]
‐ Dysgonomonas Bronchoalveolar lavage Human [1.8]
‐ Eubacterium Bronchoalveolar lavage Human [1.8]
‐ Fusobacterium Bronchoalveolar lavage Human [1.8]
‐ Fusobacterium Sputum Human [1.11]
‐ Haemophilus Bronchial wash Human [1.13]
‐ Haemophilus Sputum Human [1.14]
‐ Hallella Bronchoalveolar lavage Human [1.8]
‐ Kingella Bronchoalveolar lavage Human [1.8]
‐ Klebsiella pneumoniae Sputum Human [1.15]
‐ Lactobacilli Ameliorative Lung Mouse
‐ Lactobacillus Oropharynx swab Human [1.16]
‐ Lactobacillus Tissue biopsie Human [1.10]
‐ Leptolyngbya Bronchoalveolar lavage Human [1.9]
‐ Leptotrichia Bronchoalveolar lavage Human [1.8]
‐ Leptotrichia Oropharynx swab Human [1.17]
‐ Moraxella Bronchoalveolar lavage Human [1.9]
‐ Moraxella Sputum Human [1.14]
‐ Neisseria Bronchoalveolar lavage Human [1.9]
‐ Neisseria Sputum Human [1.11]
‐ Nocardioides Bronchoalveolar lavage Human [1.8]
‐ Olsenella Bronchoalveolar lavage Human [1.8]
‐ Oribacterium Bronchoalveolar lavage Human [1.8]
‐ Parvimonas Bronchoalveolar lavage Human [1.8]
‐ Peptostreptococcus Bronchoalveolar lavage Human [1.8]
‐ Porphyromonas Sputum Human [1.11]
‐ Prevotella Bronchoalveolar lavage Human [1.8]
‐ Prevotella Sputum Human [1.11]
‐ Pseudomonas aeruginosa Sputum Human [1.15]
‐ Pseudomonas Bronchial wash Human [1.13]
‐ Pseudomonas Oropharynx swab Human [1.16]
‐ Rothia Bronchoalveolar lavage Human [1.8]
‐ Rothia Sputum Human [1.11]
‐ Selenomonas Bronchoalveolar lavage Human [1.8]
‐ Serratia Bronchoalveolar lavage Human [1.8]
‐ Stenotrophomonas Oropharynx swab Human [1.16]
‐ Streptococcus pneumoniae Sputum Human [1.15]
‐ Streptococcus Bronchoalveolar lavage Human [1.8]
‐ Tannerella Bronchoalveolar lavage Human [1.8]
‐ TM7 Bronchoalveolar lavage Human [1.8]
‐ Undibacterium Bronchoalveolar lavage Human [1.9]
‐ Veillonella dispar Oropharynx swab Human [1.17]
‐ Veillonella Bronchoalveolar lavage Human [1.8]
‐ Veillonella Sputum Human [1.11]

↧ Microbiota

‐ Aanaerobacter Bronchoalveolar lavage Human [1.12]
‐ Acinetobacter Sputum Human [1.11]
‐ Actinobacillus Sputum Human [1.18]
‐ Actinomyces Bronchial wash Human [1.13]
‐ Actinomyces Sputum Human [1.19]
‐ Arthrobacter Bronchoalveolar lavage Human [1.8]
‐ Bacteroidetes Sputum Human [1.11]
‐ Campylobacter Sputum Human [1.11]
‐ Centipeda periodontii Bronchoalveolar lavage Human [1.9]
‐ Citrobacter Bronchoalveolar lavage Human [1.8]
‐ Clostridium Bronchoalveolar lavage Human [1.8]
‐ Corynebacterium Sputum Human [1.11]
‐ Eikenella corrodens Sputum Human [1.18]
‐ Eubacterium saburreum Bronchoalveolar lavage Human [1.9]
‐ Filifactor Oropharynx swab Human [1.17]
‐ Gemella Oropharynx swab Human [1.17]
‐ Granulicatella Sputum Human [1.20]
‐ Haemophilus parahaemolyticus Sputum Human [1.18]
‐ Haemophilus parainfluenzae Bronchoalveolar lavage Human [1.9]
‐ Humicoccus Bronchoalveolar lavage Human [1.8]
‐ Lactobacillus sakei Bronchoalveolar lavage Human [1.9]
‐ Micrococcus luteus Bronchoalveolar lavage Human [1.9]
‐ Modestobacter Bronchoalveolar lavage Human [1.8]
‐ Moraxella Sputum Human [1.18]
‐ Neisseria subflava Sputum Human [1.20]
‐ Neisseria Oropharynx swab Human [1.16]
‐ Novosphingobium Tissue biopsie Human [1.21]
‐ Oribacterium Sputum Human [1.18]
‐ Pasteurellaceae Oropharynx swab Human [1.17]
‐ Porphyromonas endodontalis Oropharynx swab Human [1.17]
‐ Prevotella nanceiensis Oropharynx swab Human [1.17]
‐ Prevotella Bronchial wash Human [1.13]
‐ Prevotella Oropharynx swab Human [1.16]
‐ Propionibacterium acnes Bronchoalveolar lavage Human [1.9]
‐ Selenomonas Bronchoalveolar lavage Human [1.9]
‐ Shewanella Sputum Human [1.11]
‐ Staphylococcus Sputum Human [1.11]
‐ Streptococcus Oropharynx swab Human [1.16]
‐ Streptococcus Sputum Human [1.14]
‐ Terrahaemophilus Bronchoalveolar lavage Human [1.9]
‐ Thermoactinomyces Bronchoalveolar lavage Human [1.8]
‐ Veillonella Bronchial wash Human [1.13]
‐ Veillonella Oropharynx swab Human [1.16]

Impact by Microbiota

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↥ Metabolome

‐ Indole-3-acetic acid (IAA) Ameliorative Lung Mouse [1.7]

↧ Metabolome

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Impact by Metabolome

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Related Factor

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Subclass

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References

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Author: MetaBiom
Identifier: 40000195
URL: https://www.metabiom.org/disease/95/chronic-obstructive-pulmonary-disease
Keywords: Microbiome, Dysbiosis, Chronic

Common References

[1.1] Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort [2021] [Research] [npj Biofilms and Microbiomes] [Journal] [80001645]
[1.2] The pulmonary mycobiome—A study of subjects with and without chronic obstructive pulmonary disease [2021] [Review] [PLOS ONE] [Journal] [80001751]
[1.3] The lower airways microbiome and antimicrobial peptides in idiopathic pulmonary fibrosis differ from chronic obstructive pulmonary disease [2022] [Study] [PLOS ONE] [Journal] [80002207]
[1.4] The Microbiome in Bronchial Biopsies from Smokers and Ex-Smokers with Stable COPD - A Metatranscriptomic Approach [2022] [Study] [COPD: Journal of Chronic Obstructive Pulmonary Disease] [Journal] [80002287]
[1.5] The Bufei Jianpi Formula Improves Mucosal Immune Function by Remodeling Gut Microbiota Through the SCFAs/GPR43/NLRP3 Pathway in Chronic Obstructive Pulmonary Disease Rats [2022] [Research] [International Journal of Chronic Obstructive Pulmonary Disease] [Journal] [80002414]
[1.6] The respiratory microbiota alpha-diversity in chronic lung diseases: first systematic review and meta-analysis [2022] [Review] [Respiratory Research] [Journal] [80002554]
[1.7] Multi-omics analyses of airway host–microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions [2022] [Study] [Nature Microbiology] [Journal] [80002555]
[1.8] The lung microbiome in moderate and severe chronic obstructive pulmonary disease. [2012] [PLOS ONE] [Journal] [80000385]
[1.9] Analysis of the airway microbiota of healthy individuals and patients with chronic obstructive pulmonary disease by T-RFLP and clone sequencing. [2013] [PLOS ONE] [Journal] [80000383]
[1.10] The lung tissue microbiome in chronic obstructive pulmonary disease. [2012] [American Journal of Respiratory and Critical Care Medicine] [Journal] [80000384]
[1.11] Metagenome and metatranscriptome profiling of moderate and severe COPD sputum in Taiwanese Han Males [2016] [PLOS ONE] [Journal] [80000876]
[1.12] The lung microbiome in moderate and severe chronic obstructive pulmonary disease [2012] [PLOS ONE] [Journal] [80000472]
[1.13] Community dynamics and the lower airway microbiota in stable chronic obstructive pulmonary disease, smokers and healthy non-smokers. [2016] [Thorax] [Journal] [80000390]
[1.14] Lung microbiome dynamics in COPD exacerbations [2016] [The European Respiratory Journal] [Journal] [80000487]
[1.15] Analysis of the bacterial community in chronic obstructive pulmonary disease sputum samples by denaturing gradient gel electrophoresis and real-time PCR. [2014] [BMC Pulmonary Medicine] [Journal] [80000249]
[1.16] Microbial communities in the upper respiratory tract of patients with asthma and chronic obstructive pulmonary disease. [2014] [PLOS ONE] [Journal] [80000380]
[1.17] Characterization of throat microbial flora in smokers with or without COPD [2017] [International Journal of COPD] [Journal] [80000840]
[1.18] Severity-Related changes of bronchial microbiome in chronic obstructive pulmonary disease [2014] [Journal of Clinical Microbiology] [Journal] [80000381]
[1.19] Sputum microbiota in moderate versus severe patients with COPD [2014] [The European Respiratory Journal] [Journal] [80000382]
[1.20] Symptom-related sputum microbiota in stable chronic obstructive pulmonary disease [2018] [International Journal of COPD] [Journal] [80000841]
[1.21] Novosphingobium and its potential role in Chronic Obstructive Pulmonary Diseases: insights from microbiome studies. [2014] [PLOS ONE] [Journal] [80000379]

Disease ⇒ Chronic Obstructive Pulmonary Disease {40000195}

Record Keys

Details

Meta Information

Notes:

Shared Reference Notes

References Notes

Common References