Clostridiales ⇒ Ruminococcaceae {10000223} Record Keys Parent:Clostridiales Definition:Ruminococcaceae Details Initialisation date:2019-08-18 LinksSource Meta Information Rank: Family Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:Mucin-degrading, Anti-cancer Notes: - The second mucin-degrading enterotype is rich in Ruminococcus and Akkermansia, both able to degrade mucins. (1)Shared Reference Notes [1.1] [#Metabolic associated fatty liver disease] -The family Ruminococcaceae has been consistently reported as less abundant in NAFLD [1.2] [#High-protein diet] - High-protein group > decreased abundance of #Veillonellaceae, #Akkermansia, uncultured #Eggerthellaceae, and Ruminococcaceae UCG-010 [1.3] [#Cancer] - Oral administration of #Castalagin > enriched for bacteria associated with efficient immunotherapeutic responses (Ruminococcaceae and #Alistipes) and improved the CD8+/Foxp3+CD4+ ratio within the tumor microenvironment. [1.4] [#High Fat Diet] - HFD > decrease relative abundance of #Verrucomicrobia, #Akkermansia , Ruminococcaceae_UCG-014 and #Bifidobacteriaceae [#Bifidobacteriaceae] [#Moderate Treadmill Exercise] - Exercise > increase the relative abundance of #Verrucomicrobia, #Akkermansia and Ruminococcaceae_UCG-014 [1.5] [#Infectious diarrhea] - A drastic disappearance of obligate anaerobic gut commensals (#Blautia, #Prevotella, #Faecalibacterium, #Lachnospiraceae, Ruminococcaceae, etc.), leading to a depletion of associated metabolites such as #Short Chain Fatty Acid (SCFAs) [1.6] [#Heart failure] [#Eubacterium hallii, #Lachnospiraceae] - patients with HF have a decrease in #Butyrate-producing bacteria, especially, Lachnospiracea and Ruminococcacea families. - reduction of the #Butyrate-producing Eubacterium Halli and Lachnospiracea is correlated with increased inflammation, severity of disease, heart damage and mortality - bacteria with capacity of butyrate production, #Lachnospiraceae and Ruminococcaceae, were depleted in individuals at a high risk of #Stroke. Fecal butyrate concentrations also were low in these people [1.7] [#Parkinson’s Disease] - #Prevotellaceae (Prevotella), Ruminococcaceae (#Faecalibacterium), #Lachnospiraceae (#Blautia, #Roseburia) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD [1.8] [#Inflamatory bowel disease, #Systemic anti-microbiota IgG] - a modified high-throughput, culture-independent approach to quantify systemic IgG against gut commensal bacteria in human serum samples without the need for paired stool samples. - Using this approach, we highlight several commensal bacterial species that elicit elevated IgG responses in patients with inflammatory bowel disease (IBD) including taxa within the clades #Collinsella, #Bifidobacterium, #Lachnospiraceae, and Ruminococcaceae. [1.9] [#Rheumatoid Arthritis] -IgG and IgA autoantibodies from individuals who are at risk for RA cross-react against gut bacteria in the #Lachnospiraceae and Ruminococcaceae families. - Analysis identified a bacterial strain from the #Subdoligranulum genus that was associated with autoantibody development. - Mice colonized with this #Subdoligranulum isolate developed arthritis with pathology similar to human RA. [#Rheumatoid Arthritis] - IgG and IgA autoantibodies from individuals who are at risk for RA cross-react against gut bacteria in the #Lachnospiraceae and Ruminococcaceae families. - RA > a bacterial strain from the Subdoligranulum genus (#Subdoligranulum didolesgii) that was associated with autoantibody development. [1.11] [#Bipolar disorder] - Ruminococcaceae at genus and family levels have been found to be depleted in cases of both uni- and bipolar #Depression [#Depression] [#Christensenellaceae, #Coprococcus eutactus, #Lachnospiraceae] - RuminococcaceaeUCG005 as the most important genus in predicting depressive symptoms. - #Sellimonas, #Eggerthella, #Lachnoclostridium and #Hungatella were more abundant in individuals with higher depressive symptoms. - 12 genera and 1 microbial family associated with depressive symptoms > genera #Sellimonas, #Eggerthella, Ruminococcaceae (UCG002, UCG003, UCG005), #Lachnoclostridium, #Hungatella, Coprococcus, LachnospiraceaeUCG001, Ruminococcusgauvreauiigroup, #Eubacterium ventriosum, #Subdoligranulum and family Ruminococcaceae. [1.12] - #Resistant starch prebiotic fibers > increase Prevotella and families #Lachnospiraceae and Ruminococaceae [1.13] - #Fasting > increased microbiome diversity and was specifically associated with upregulation of the #Clostridiales order–derived #Lachnospiraceae and Ruminococcaceae bacterial families. - increased #Lachnospiraceae > #Butyrate [1.14] [#Bipolar disorder] - BD patients with a depressive episode > increased levels of #Coriobacteria and #Actinobacteria together with decreased Ruminococcaceae and #Faecalibacterium. [1.15] [#Short Chain Fatty Acid] - in #Centenarians, longevity is positively associated with an abundance of short-chain fatty acid (SCFA) producers, such as #Clostridium cluster XIVa, Ruminococcaceae, #Akkermansia, and #Christensenellaceae [1.16] - in severe #Depression > reduced #Bifidobacteriaceae and #Prevotellaceae with elevated #Enterobacteriaceae and Ruminococcaceae. [1.17] [#Diabetes Type 2] Diabetes : - The gut–brain–beta cell glucagon-like peptide-1 (GLP-1)-dependent axis and the clock genes both control insulin secretion. - GLP-1sensitivity is maximal during the dark feeding period, i.e., the postprandial state. - The abundance of ileum bacteria, particularly Ruminococcaceae and #Lachnospiraceae, oscillated diurnally, with a maximum during the dark period, along with expression patterns of a subset of clock genes. - This diurnal pattern of circadian gene expression and #Lachnospiraceae abundance was also observed in two separate mouse models of gut microbiota dysbiosis and of autonomic neuropathy with impaired GLP-1 sensitivity. [1.18] [#Anorexia nervosa] - The Ruminococcacea-enterotype was more prevalent in cases of AN. [1.19] [#Alzheimer’s disease, #Amyotrophic lateral sclerosis, #Multiple Sclerosis] - ALS appeared to be less associated with microbial dysbiosis compared to MS and AD, with only one microbe genus, #Methanobrevibacter and Ruminococcaceae being commonly present under elevated conditions, respectively. - positive emotions were inversely associated with the relative abundance of #Firmicutes bacterium CAG 94 and Ruminococcaceae bacterium D16, while negative emotions were directly correlated with the relative abundance of these same species. [1.21] [#Whole grains] - Several #Butyrate-producers (e.g., #Faecalibacterium, #Roseburia, Butyriciococcus) were inversely associated with colonic transit time and/or faecal pH, while the mucin-degraders #Akkermansia and Ruminococcaceae showed the opposite association. [1.22] [#Antibiotic Therapy] - Postnatal antibiotic exposure > reduced relative abundance of #Lachnospiraceae (for example, #Dialister spp. and #Lachnospira spp.) and Ruminococcaceae and increased relative abundance of #Veillonella. [#Children] - delayed entry into #Daycare is associated with reduced relative abundance of #Lachnospiraceae, Ruminococcaceae and #Prevotella spp. and delayed maturation of the gut microbiome. [1.23] [#Hypertension] [#Short Chain Fatty Acid] - normotension group exhibited higher levels of Gram-positive bacteria, such as #Clostridia, Ruminococcaceae, and #Lachnospiraceae, which are mostly SCFA-producing bacteria. [#Plant-based diet] - Ruminococcaceae is associated with the long-term consumption of fruits and vegetables. - Ruminococcaceae enterotype has been linked to adults on a Korean-style balanced diet [1.24] [#High fibre diet, #Nuts] - nut fibers stimulated family #Lachnospiraceae- and Ruminococcaceae-related OTUs. [1.25] - especially in #Crohn’s disease, is the decreased abundance of #Firmicutes bacteria belonging to two families that are important functional members of the human gut microbiota─Ruminococcaceae and #Lachnospiraceae─to which most #Butyrate-producing bacteria in the human gut belong. [1.26] [#Chronic fatigue syndrome] - genus #Paraprevotella and Ruminococcaceae_UCG_014 were positively associated with ME/CFS risk. [1.27] [#Inflamatory bowel disease] - The #Clostridium XlVa cluster and Ruminococcaceae are also reduced in those with inflammatory bowel disease (IBD) compared to those without disease, which agrees with their protective role in the gut inflammation and an anti-inflammatory effect of #Aspirin on the gut microbiome. [#Polysaccharide, #Short Chain Fatty Acid] - Ruminococcaceae degrade several types of polysaccharides in the lower gastrointestinal tract and facilitate the production of protective short-chain fatty acids [1.28] - protective role against #Female infertility, > #Ruminococcus, #Desulfovibrio. #Bifidobacteriales, #Bifidobacterium, #Actinobacteria, Ruminococcaceae NK4A214, #Bifidobacteriaceae, #Actinobacteria, #Holdemania. [1.29] [#Systemic lupus erythematosus] - increased abundance in #Enterobacteriaceae and #Enterococcaceae and decreased abundance in Ruminococcaceae in the gut microbiota of patients with SLE. [#Metabolic associated fatty liver disease] - #Coriobacteriia, #Actinomycetales, #Oxalobacteraceae, Ruminococcaceae_UCG005 are positively associated with non-alcoholic fatty liver disease. [1.31] [#Inflamatory bowel disease] [#Faecalibacterium prausnitzii] - Decreased abundance on #Firmicutes bacteria belonging to the Ruminococcaceae spp., #Lachnospiraceae spp, F. prausnitzii and #Roseburia spp. families is a signature of microbial dysbiosis in IBD. [1.32] [#ICI therapy] - #Bacteroidetes remained the most common gut bacteria with increased levels of Ruminococcacae and #Akkermansia muciniphila after treatment which is in contrast to patients who did not respond to anti-PD-1 therapy and had increasing levels of #Proteobacteria after treatment, [1.33] [#Metabolic syndrome] - Ruminococcaceae UCG-014 was disadvantageous for weight loss, while Ruminococcaceae NK4A214 and #Ruminococcus 1 were advantageous for weight loss and change in waist circumference. - baseline abundance of this taxon was positively associated with DNAme in three metabolically relevant genes. [1.34] [#Ulcerative Colitis] [#Short Chain Fatty Acid] - UC > depletion of SCFA-producing #Bacteria such as #Prevotella, #Roseburia, #Lachnospiraceae, and Ruminococcaceae. [1.35] [#Pulmonary tubercolosis, #Tuberculosis] - The genera #Parabacteroides, #Bacteroides, #Lachnoclostridium, and #Fusobacterium were markedly enhanced in the PTB group, while #Roseburia, #Blautia, unidentified Ruminococcaceae, #Bifidobacterium, #Romboutsia, and #Fusicatenibacter were enhanced in the HC group. [1.36] [#Parkinson’s Disease] - #Prevotellaceae, #Lachnospiraceae, and #Faecalibacterium were decreased significantly in patients with PD compared to healthy controls, while Ruminococcaceae, #Bifidobacteriaceae, #Christensenellaceae, and #Verrucomicrobiaceae were enriched in patients with PD [1.37] [#Multiple Sclerosis] - #Children with MS exhibit low levels of #Lachnospiraceae and Ruminococcaceae and significant levels of #Desulfovibrionaceae members [1.38] [#Rheumatoid Arthritis] - #High humidity aggravated joint injury in CIA rats, which may be related to the high abundance of bacterial species such as #Prevotella, #Clostridia, and Ruminococcaceae_UCG_010 induced by #High humidity, which could promote the immune response of Th17 cells. [#Rheumatoid Arthritis] - #Prevotella, Ruminococcaceae and #Clostridia were associated with RA because they induce the inflammatory response mediated by #IL-6, #IL-17 and IFN-γ cytokines [1.39] - decrease in the Ruminococcaceae after #Hyperoxia exposure in the cecal microbiota of these #Adult mice [#Phenylacetylglutamine] - circulating PAG levels to different families of gut microbes such as #Coriobacteriaceae, #Mogibacteriaceae, #Bifidobacteriaceae, with genera in the #Lachnospiraceae, #Christensenellaceae and Ruminococcaceae families and with gut microbiome diversity. [1.41] [#Liver fibrosis, #Metabolic associated fatty liver disease] - supplementation with #Lachnospiraceae and Ruminococcaceae can protect against obesity, inflammation, intestinal dysbiosis, and hepatic #Fibrosis in MASLD - increase in #Lachnospiraceae, Ruminococcaceae, and #Lactobacillus species following #Beta-glucan treatment. [#Liver fibrosis, #Metabolic associated fatty liver disease] - increased abundance of the Ruminococcaceae genus in patients with higher degrees of hepatic fibrosis. [1.42] [#mRNA vaccine] - #Methanobrevibacter, Ruminococcaceae #DTU089, #Marvinbryantia, #Cloacibacillus, and #Succinivibrio were enriched in the baseline microbiome of individuals with low IgG titers and low spike-specific CD4+ T-cell responses. [#Covid-19] [#mRNA vaccine] - high spike IgG levels, with less abundance of bacterial groups belonging to #Clostridiales and #Methanobacteriales, such as Ruminococcaceae #DTU089 and #Methanobrevibacter, respectively. [1.43] [#Collagen-induced arthritis , #Rheumatoid Arthritis, #Spondyloarthritis] [#Lachnospiraceae bacterium] - in CIA (such as Lachnospiraciae and Lactobacillaeae), RA (#Lachnospiraceae bacterium, #Lactobacillus spp., #Faecalibacterium), and SpA (Ruminococcaceae, #Rikenellaceae, #Porphyromonadaceae, #Bacteroidaceae, #Lachnospiraceae) are either predicted or known to produce #Indole [1.44] [#Serotonin, #Tryptophan] - #Fructooligosaccharides have been shown to modulate the gut microbial composition, by decreasing the abundance of #Akkermansiaceae (family level) and #Verrucomicrobia (phylum level) and increasing the abundance of Ruminococcaceae (phylum level), and to increase the levels of Trp and 5-HT in mice models [1.45] - #Chronic liver disease > #Incertae sedis from Ruminococcaceae showed a protective effect, reducing mortality risk, whereas increased #Veillonella presence was associated with a higher risk [1.46] - #Akkermansia, #Butyrivibrio, #Holdemania, and Ruminococcaceae UCG-011 were identified as protective factors for #Hypothyroidism, whereas #Anaerostipes, #Intestinimonas, and Ruminiclostridium5 were found to have negative effects on the condition. [1.47] - Four bacterial species, including Ruminococcaceae UCG010, #Butyricimonas, #Pasteurellaceae and #Lactobacillus independently influence the development of various types of #Obesity. - Ruminococcaceae UCG010 independently reduced the risk of #Obesity induced by excessive calorie intake [1.48] [#Deoxycholic acid, #Lithocholic acid] - Ruminococcaceae families perform the subsequent 7α-dehydroxylation of CA and CDCA to respectively generate DCA and LCA, has been associated with #Intermittent Hypoxia and hypercapnia conditions [1.49] [#Metabolic associated fatty liver disease] - #Ruminiclostridium and #Streptococcus were enriched in patients with #Obesity and MAFLD. - these changes remained significant for Ruminococcaceae UCG-008 even after correction for multiple comparisons [#Metabolic associated fatty liver disease] - Patients with lean MAFLD exhibited enrichment in #Erysipelotrichaceae UCG-003, #Ruminococcus, #Clostridium sensu stricto 1, #Romboutsia, and Ruminococcaceae UCG-008. [#Prostate cancer] [#Omega 3] - Supplementation with long-chain fatty acids (LCFA) omega-3 MAG-EPA is sufficient to reduce PCa growth in mice and cancer up-grading in pre-prostatectomy PCa patients correlating with a reduction of gut Ruminococcaceae in both and fecal #Butyrate levels in PCa patients. [1.51] [#Organophosphorus] - Most abundance changes at the genus level associated with high ambient OP exposure belong to the #Lachnospiraceae (seven genera were increased and two were decreased) and Ruminococcaceae (3 genera were increased and 2 were decreased) families in the #Clostridia class. [1.52] [#High Fat Diet] - Ruminococcaceae (order Clostridiales) that are prominent producers of #Butyrate, decreased in relative abundance with a high-fat diet. - This decrease is particularly significant because Ruminococcaceae, making up ≈20% of gut bacteria in chow-fed OSA rats, decreased to ≈10% in high-fat OSA rats . Members of the order Clostridiales, other than Ruminococcaceae, also significantly decreased with high-fat diet.References Notes (1) [1.117] (2) [1.118]
