Clostridiales ⇒ Blautia {10000258}

Shared Reference Notes

• [1.1] [#Diabetes Type 1] 
  - In patients with type 1 diabetes, elevated Blautia abundance was observed and was correlated with increased IA-2 tyrosine phosphatase autoantibodies, important markers of autoimmunity.
• [#Diabetes Type 1] - In patients with type 1 diabetes, elevated Blautia abundance was observed and was correlated with increased IA-2 #Tyrosine phosphatase autoantibodies, important markers of autoimmunity.
• - Increased Blautia has also been seen in #Obesity, Alzheimer’s disease, nonalcoholic fatty liver disease, and #Multiple Sclerosis.
• [#Posttreatment Lyme disease syndrome] - Blautia species represented three of the five most important features for this classification, and the relative abundance was elevated in the PTLDS cohort compared to those in the healthy and ICU cohorts.
• [1.2] 
  - The proportions of Blautia and F. Prausnitzii and absolute numbers of Blautia and Bifidobacterium species in the gut microbiome are directly correlated with the clinical stage of #Breast cancer. - For instance, patients with stage 1 #Breast cancer had a lower number of gut Blautia sp. in comparison with the ones with stage grade 3
• [1.3] 
  - #Protein powder consumption > decrease in #Lachnospiraceae, #Roseburia, Blautia, Synergistales, #Coprococcus, #Lactobacillales, Bacilli, #Bifidobacterium longum and #Firmicutes. - #Protein powder consumption > higher abundance of #Bacteroidetes.
• [1.4] 
  - Severe Covid > higher abundance of four microbial species (i.e., #Burkholderia contaminans, #Bacteroides nordii, #Bifidobacterium longum, and Blautia sp. CAG 257), six microbial pathways (e.g., glycolysis and fermentation), and 10 virulence genes > further associated with host immune response. - The abundance of Bu. contaminans > associated with higher levels of inflammation biomarkers and lower levels of immune cells. - human-origin proteins identified from both blood and fecal samples suggested gut barrier dysfunction in #Covid-19 patients. - The circulating levels of #Lipopolysaccharide-binding protein increased in patients with severe illness > associated with circulating inflammation biomarkers and immune cells. - proteins of disease-related bacteria (e.g., B. longum) were detectable in blood samples from patients.
• [1.5] [#Psychogenic erectile dysfunction] 
  - Erectile dysfunction > no #Alloprevotella . - Erectile dysfunction > increased #Streptococci and #Subdoligranulum - Erectile dysfunction > decreased #Prevotella sp.9, Blautia, #Lachnospiraceae NK4A136 groups and #Roseburia.
• [1.6] [#Chronic fatigue syndrome] 
  - MC/CFS > microbiome alterations that were consistent with an increased inflammation of the gut, namely significantly increased #Lactonifactor and #Alistipes - in particular an increase of #Alistipes and a decrease of butyrate-producer #Faecalibacterium were considered as top biomarkers with potential diagnostic value - abundance of #Bifidobacterium and #Faecalibacterium to be reduced in the affected twin compared to the non-affected one. - Decreases in #Faecalibacterium and increases in #Coprobacillus were found. - Gut abundances of #Coprobacillus, of #Eggerthella and Blautia were best able to distinguish patients from controls. - distinct microbial pattern with decreased anti-inflammatory #Firmicutes
• [1.7] [#Infectious diarrhea] 
  - A drastic disappearance of obligate anaerobic gut commensals (Blautia, #Prevotella, #Faecalibacterium, #Lachnospiraceae, #Ruminococcaceae, etc.), leading to a depletion of associated metabolites such as #Short Chain Fatty Acid (SCFAs)
• [1.8] [#Hypertension] 
  - Abundance of Blautia and #Odoribacter showed a negative correlation with high SBP
• [1.9] [#Parkinson’s Disease] 
  - #Prevotellaceae (Prevotella), #Ruminococcaceae (#Faecalibacterium), #Lachnospiraceae (Blautia, #Roseburia) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD
• [#Ulcerative Colitis] [#Primary bile acids, #Secondary bile acids] - colonic CD displayed a disease-severity-related association with #Bacteroides vulgatus. - Compared to colonic CD, ileal CD profiles displayed increased primary and secondary bile acid levels and concomitant shifts in taxa with noted sensitivities such as #Faecalibacterium prausnitzii or affinities for bile acid-rich environments, including #Gammaproteobacteria and Blautia sp.
• [1.11] [#Multiple Sclerosis] [#Blautia wexlerae, #Erysipelotrichaceae CCMM] 
  - In both progressive MS and RRMS > increased #Clostridium bolteae, #Ruthenibacterium lactatiformans, and #Akkermansia and decreased Blautia wexlerae, #Dorea formicigenerans, and #Erysipelotrichaceae CCMM. - Unique to progressive MS, has elevated Enterobacteriaceae and Clostridium g24 FCEY and decreased Blautia and #Agathobaculum.
• [1.12] [#Infants, #Mother-infant] 
  - Maternal gut strains transmitted after the first 3 months of life included members of the genera #Eubacterium, #Roseburia, and Blautia.
• [1.13] [#Polyphenols] 
  - Blautia sp. MRG-PMF1 metabolizes #Curcumin to produce demethylcurcumin and bisdemethylcurcumin through a demethylation reaction.
• [1.14] [#Gastric bypass surgery] 
  - #Lactococcus, #Streptococcus, and #Granulicatella are #Lactate-producing microorganisms, whereas #Dorea and Blautia are #Lactate oxidizers
• [1.15] [#Multiple Sclerosis] [#Lipocalin-2] 
  - bacteria thought to be beneficial for inflammatory bowel disease (IBD) such as #Anaerobutyricum, Blautia, and #Roseburia, were reduced in fecal Lcn-2-high MS patients.
• [1.16] [#Crohn’s disease] [#Clostridium cluster IV] 
  - #Roseburia, #Gemmiger, #Coprococcus, #Ruminococcus 2, #Butyricicoccus, #Dorea, #Fusicatenibacter, #Anaerostipes, Clostridium IV were enriched in the healthy controls. - Blautia, Clostridium IV, #Coprococcus, #Dorea, #Fusicatenibacter continued to significantly decrease in early and advanced CD patients, and Escherichia/Shigella and Proteus continued to significantly increase. - negative correlation between #Dorea, #Butyricicoccus, #Roseburia and gland reduce, #Roseburia and FC, #Butyricicoccus and goblet cells decreased, Parabacterodies and sex, Clostridium IV and CRP, #Dorea and ESR . - positive correlation between Escherichia/Shigella and CRP, #Ruminococcus 2 and clinical symptoms.
• [1.17] [#Diabetes Type 2] 
  - The genus Blautia was one of the most represented genera in both groups enriched in group T2D. - #Lachnoclostridium were more abundant in the microbiome profiles of diabetic patients. - There are anomalies in the genera #Bacteroides and #Prevotella, both of which are increased in the T2D, both genera are #Propionate producers.
• [1.18] 
  - #Inulin > increase genera Blautia, #Anaerostipes, and #Bifidobacterium
• [1.19] [#Systemic lupus erythematosus] [#Flavonoid, #Polyphenols] 
  - dietary polyphenol as dihydrochalcones and flavanones affected the gut microbiome and ameliorated lupus disease activity. - dietary flavones increased Blautia (family: Lachnospiraceae), and that often found in active lupus diseases.
• [#Anorexia nervosa] [#Clostridium bolteae, #Clostridium innocuum] - In AN : #Erysipelatoclostridium ramosum, Blautia species CAG, and Enterocloster bolteae innocuum (#Clostridium) were increased.
• [1.21] [#Behcet’s Disease] 
  - Depleted #Dorea, Blautia, #Coprococcus, #Erysipelotrichaceae and #Lachnospiraceae as well as enriched #Bilophila and #Stenotrophomonas were identified in BU patients.
• [1.22] [#Olive] 
  - both the #Peanut oil and EVOO significantly increased the relative abundance of #Bifidobacterium and reduced Blautia levels and also had favorable effects on body weight, #Cholesterol levels, and insulin sensitivity.
• [#Olive] - EVOO has demonstrated antibacterial and bacteriostatic effects against bacteria such as those in the #Desulfovibrionaceae,a family of opportunistic pathogens associated with #Obesity and inflammation, and Blautia spp., which positively correlates with visceral fat accumulation in Japanese men and women.
• [1.23] [#Crohn’s disease] 
  - The microbiome risk score (MRS) model yielded a hazard ratio (HR) of 2.24 and temporal validity by capturing individuals that developed CD up to five years prior to disease onset. The five most important taxa contributing to the MRS included #Ruminococcus torques, Blautia, #Colidextribacter, an uncultured genus-level group from Oscillospiraceace, and #Roseburia.
• [1.24] 
  - delayed maturation of the gut microbiome (characterized by reduced relative abundance of the genera #Roseburia, #Dialister, #Prevotella, #Faecalibacterium and Blautia and increased abundance of #Enterococcus), as well as reduced stool levels of #Butyrate by the age of 12 months, is associated with aberrant immune responses and an increased risk of #Asthma diagnosis by the age of 5 years
• [1.25] [#Bacteroides-Prevotella group] 
  - only #Faecalibacterium, but not Blautia, #Anaerostipes, or #Megamonas, was significantly lower in the #Hypertension group
• [1.26] [#Celiac Disease] 
  - #Bacillus subtilis LZU-GM was isolated from Pakistani traditional fermented sourdough and could degrade 73.7% of #Gluten in 24 h in vitro. - The #Gluten degradation was 3-fold higher in the small intestine of the strain LZU-GM treated mice group. - #Gluten-treated mice established positive antigliadin antibodies (AGA) in serum (IgA, IgG, and anti-TG2 antibodies) as compared to the strain LZU-GM treatment group. - the number of IFN-γ, TNF-α, #IL-10, and COX-2 cells decrease in the lamina propria of the strain LZU-GM treatment group. - Microbial community bar plot analysis showed that #Lactobacillus, #Dubosiella, and #Enterococcus genera were restored and stabilized in the LZU-GM treatment group while Blautia and #Ruminococcus were found lower.
• [1.27] [#Crohn’s disease] [#Dorea longicatena, #Ruminococcus lactaris] 
  - ileocolonic resection (ICR) in CD patients > amples collected at time of surgery were enriched in #Proteobacteria and harbored high levels of unusual, bacteria such as #Streptococcus mitis, #Undibacterium oligocarboniphilum, #Sphingomonas melonis and #Gemella haemolysans - 6 months after surgery samples had elevated proportions of anaerobic bacteria belonging to #Lachnospiraceae (#Clostridium nexile, Blautia wexlereae, #Dorea longicatena). - Remission was characterized by increased levels of bacteria belonging to #Bacteroides, #Dorea, #Ruminococcus and #Dialister genera, whereas recurrence was associated with increased levels of #Gemmiger formicilis, #Enterococcus durans and #Ruminococcus lactaris.
• [1.28] [#Bacteroides vulgatus] [#carrot-derived rhamnogalacturonan I] [#Carrot] 
  - cRG-I supplementation (already at an HED of 0.3 g/d) lowered interpersonal compositional differences due to the selective stimulation of taxa that were consistently present among human adults, including OTUs related to #Bacteroides dorei/vulgatus and #Bifidobacterium longum (suspected keystone species), #Bacteroides thetaiotaomicron, #Bifidobacterium adolescentis and #Butyrate-producing taxa such as Blautia sp., #Anaerobutyricum hallii, and #Faecalibacterium prausnitzii.
• [1.29] 
  - Blautia, #Faecalibacterium, and #Dorea levels were consistently more abundant in 8-year-olds with #Allergy than in #Children without #Allergy. - #Faecalibacterium abundance was correlated with IL-10 and FOXP3 mRNA levels.
• [#Obesity] [#Western-style diet] - in western populations, Blautia genus abundance is directly correlated with both BMI and visceral fat, but the inverse relationship is observed in studies in Japanese and Chinese populations where decreasing in relative abundance of Blautia in the gut microbiome, is associated with increased visceral fat
• [1.31] [#Systemic lupus erythematosus] [#Ruminococcus gnavus] 
  - Expansions of only the anaerobic commensal, Ruminococcus (blautia) gnavus (RG) occurred at times of high-disease activity, and were detected in almost half of patients during lupus nephritis (LN) disease flares.
• [1.32] 
  - Blautia, Fecalibacterium, and #Dorea were found to be related to cognition function and could alleviate the inflammatory reaction in #Cirrhosis patients
• [1.33] 
  - pPobiotic supplementation during #Antibiotic Therapy has a protective effect on Blautia and #Roseburia spp. levels - Blautia level has a tendency to normalize spontaneously after #Antibiotic Therapy.
• [1.34] [#Crohn’s disease] 
  - CD patients had higher abundances of a #Ruminococcus taxon and strongly depleted in a Blautia ASV, and previous csDMARD therapy was associated with increased #Akkermansia.
• [1.35] [#Parkinson’s Disease] [#Short Chain Fatty Acid] 
  - Decreases of short-chain fatty acid-producing genera, #Fusicatenibacter, #Faecalibacterium, and Blautia, as well as an increase of mucin-degrading genus #Akkermansia, predicted accelerated disease progression.
• [1.36] 
  - patients with #Celiac Disease showed the abundance of #Streptococcus, #Lactobacillus, #Veillonella, and #Allisonella species, while the abundance of #Ruminococcus, #Faecalibacterium, Blautia, #Gemmiger, and #Anaerostipes was decreased.
• [1.37] [#Metabolic Dysfunction-associated Steatohepatitis] [#Ginger] 
  - GEO reduced the relative abundance of NASH-associated bacteria, including Blautia and #Tyzzerella, which are considered harmful.
• [#Metabolic Dysfunction-associated Steatohepatitis] [#Lipopolysaccharide] - Blautia abundance increased in NASH patients and was positively correlated with LPS levels
• [1.38] [#Ulcerative Colitis] [#Prevotella] 
  - Prevotella_7 and Blautia taxa abundance, as well as two metabolic pathways, might serve as a discriminating signature between north Indian UC patients with active disease and those in remission.
• [1.39] 
  - #HDL had a positive association with Elusimicrobium and #Ezakiella, whereas #Dorea and Blautia were negatively associated with #Glucose
• [#Pulmonary tubercolosis, #Tuberculosis] - The genera #Parabacteroides, #Bacteroides, #Lachnoclostridium, and #Fusobacterium were markedly enhanced in the PTB group, while #Roseburia, Blautia, unidentified #Ruminococcaceae, #Bifidobacterium, #Romboutsia, and #Fusicatenibacter were enhanced in the HC group.
• [#Bacteroides-Prevotella group, #Ruminococcus gauvreauii] [#Keto diet] - The abundance of Ruminococcus_gauvreauii_group, #Bacteroides, #Bifidobacterium, and Blautia significantly increased, whereas that of #Lactobacillus, #Romboutsia, #Facklamia, and #Turicibacter significantly declined in the KD group compared with the ND group.
• [1.41] [#Parkinson’s Disease] [#Roseomonas mucosa] [#Short Chain Fatty Acid] 
  - #Constipation severity is significantly correlated with the decrease of Blautia and #Faecalibacterium, short chain fatty acids (SCFAs)-producing taxa that can exert positive effects on the intestinal mucosa and which are decreased in PD.
• [1.42] [#Multiple Sclerosis] 
  - Individuals with relapsing-remitting MS have an abundance of #Mycoplasma, #Pseudomonas, #Faecalibacterium, #Haemophilus, #Anaerostipes, Blautia, and #Dorea, while #Bacteroides, #Prevotella, #Parabacteroides, and #Adlercreutzia are relatively less common.
• [1.43] [#Primary immune thrombocytopenia] 
  - fecal bacteria such as #Actinomycetaceae, Blautia, #Streptococcus, and #Lactobacillus are enriched, whereas bacteria such as #Bacteroides are depleted in ITP patients.
• [1.44] [#High Fat Diet] 
  - Blautia (e.g., ASV24) and #Bilophila (e.g., ASV37) which had been observed with increased abundance upon HFD feeding
• [1.45] [#Juvenile idiopathic arthritis] [#Blautia faecis] 
  - Blautia faecis was completely absent in ABIS JIA but occurred in half of controls; a reduced incidence of Blautia has been previously noted cross-sectionally.
• [1.46] [#Fasting] 
  - RIF was associated with significant drops in the levels of seven genera at the end of Ramadan: Blautia, #Coprococcus, #Dorea, #Faecalicatena, #Fusicatenibacter, #Lachnoclostridium, and #Mediterraneibacter.
• - Blautia was more abundant before Ramadan #Fasting.
• [#Diabetes Type 2] - Blautia produces #Acetic acid and significantly correlates with host physiological dysfunctions, such as #Obesity, diabetes, and various inflammatory diseases. - An increase in Blautia abundance may inhibit insulin signaling and prevent fat accumulation in adipocytes
• [#Obesity] - individuals with an overweight phenotype have increased levels of specific bacterial genera in the #Firmicutes phylum, including Blautia, #Coprococcus, and #Dorea
• [1.47] [#Cognitive impairment] 
  - genus #Roseburia, Blautia, Catenibacteriu, and #Oxalobacter had a negative impact on cognitive performance, with #Roseburia strongly associated with outcome.
• [1.48] [#Diabetes Type 2] 
  - #Lachnospiraceae microbiome was associated with an excess of faecal monosaccharides. - the increased presence of #Lachnospiraceae (#Dorea, Blautia) in the gut microbiota was positively correlated with IR.
• [1.49] [#Tryptophan] 
  - Trp is converted to #Indole via the enzyme Trp identified in gut bacteria such as #Escherichia coli (E. coli), #Clostridium spp., and #Bacteroides spp. - Trp decarboxylase converts Trp to #Tryptamine > is expressed in #Clostridium, #Ruminococcus, Blautia, and #Lactobacillus bacteria
• [#Schizophrenia] - Megasphera, #Akkermansia, #Fusobacterium and #Prevotella were significantly more abundant in SCZ patients, and #Citrobacter, Blautia, #Coprococcus, #Lachnoclostridium were more abundant in HC controls.
• [1.51] [#Diabetes Type 2] 
  - Blautia, #Faecalibacterium, #Bifidobacterium, #Clostridium, #Anaerostipes, #Mediterraneibacter, and #Butyricicoccus abundances were relatively higher in healthy fecal samples than in prediabetic fecal samples.
• [1.52] [#Anthocyanins] 
  - Subtle differences were observed in the faecal microbiota of subjects that were fed the different apples, with significant reductions in relative abundances of #Streptococcus, #Ruminococcus, Blautia, and #Roseburia, and increased relative abundances of #Sutterella, #Butyricicoccus, and #Lactobacillus in subjects after consuming the red #Apple. - anthocyanin-rich apples may influence immune function compared to control apples
• [1.53] [#Short Chain Fatty Acid] 
  - adults with #Prediabetes > #Metformin > increased the abundance of GM SCFA-producing bacteria M (#Fusicatenibacter and Blautia) - adults with #Prediabetes > linagliptin/#Metformin > Roseburia, Bifidobacterium, and [Eubacterium] hallii group.
• [1.54] [#Blautia coccoides] [#High fibre diet] 
  - individuals who increase their daily dietary fiber intake can improve the capacity of their gut microbiota to prevent diet-mediated mucus defects. - Mucus growth, a critical feature of intact colonic mucus, correlated with the abundance of the gut commensal Blautia, and supplementation of Blautia coccoides to mice confirmed its mucus-stimulating capacity.
• [1.55] [#Ruminococcus] 
  - Specific human gut microbes, including Ruminococcus_E, #Agathobacter, #Fusicatenibacter, #Anaerobutyricum, Blautia_A and #Neisseria, were identified as potential consensus microbial biomarkers for #Obesity in the population.

References Notes