Rikenellaceae ⇒ Alistipes {10000159} Record Keys Parent:Rikenellaceae Definition:Alistipes Details Initialisation date:2019-08-04 LinksSource Meta Information Rank: Genus Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:Non-Alocoholic Fermentation, Pro-inflamatory Notes: - Alistipes, which helps ferment our food without producing alcohol, generally improves the metabolic status of our gut and makes us more proficient at using the glucose we consume for energy. - Alistipes is found in plants. High levels can be found in the gut of hibernating bears. (1)Shared Reference Notes [1.1] - Increased relative abundances of fecal #Oscillibacter and Alistipes > causally linked to decreased #Triglyceride concentration. [1.2] [#Cancer] - Oral administration of #Castalagin > enriched for bacteria associated with efficient immunotherapeutic responses (#Ruminococcaceae and Alistipes) and improved the CD8+/Foxp3+CD4+ ratio within the tumor microenvironment. [1.3] [#Chronic fatigue syndrome] - MC/CFS > microbiome alterations that were consistent with an increased inflammation of the gut, namely significantly increased #Lactonifactor and Alistipes - in particular an increase of Alistipes and a decrease of butyrate-producer #Faecalibacterium were considered as top biomarkers with potential diagnostic value - abundance of #Bifidobacterium and #Faecalibacterium to be reduced in the affected twin compared to the non-affected one. - Decreases in #Faecalibacterium and increases in #Coprobacillus were found. - Gut abundances of #Coprobacillus, of #Eggerthella and #Blautia were best able to distinguish patients from controls. - distinct microbial pattern with decreased anti-inflammatory #Firmicutes [1.4] [#Sleep Deprivation] - fecal #Butyrate concentrations positively correlated with the relative abundance of #Butyricimonas. - the abundance of SCFAs-producing microbes, such as #Butyricicoccus, #Butyricimonas, and Alistipes markedly decreased after SD. - #Butyrate > significantly reduced after 48 h of SD > After 1 week of sleep recovery, #Butyrate concentrations returned. [1.5] - A higher relative abundance of Alistipes species has been reported in children with #Autism, pervasive developmental disorder not otherwise specified (PDD-NOS) , and depression. - Alistipes may disrupt the gut–brain axis by decreasing #Serotonin (indole-positive organism) and impair cognition by producing #Propionic acid in rats. [1.6] [#Human gammaherpesvirus 4] - #Tomato > Fruitflow when administered over 4 wk at 2×150 mg Fruitflow per d > Significant changes in relative abundance of microbial taxa with Fruitflow, such as decreases in #Bacteroides, Ruminococccus, and #Hungatella related OTUs, as well as increases in Alistipes which are all known for the involvement in #TMA/#TMAO metabolism. [1.7] [#Diabetes Type 2] - A significant reduction of genera Alistipes, #Anaerostipes, #Ruminococcus was detected in the T2D group. [1.8] [#Plastics] - Alistipes was increased under the intervention of food grade plastic bags. [1.9] [#Bipolar disorder, #Major depressive disorder, #Schizophrenia] - MDD was often characterized by higher Alistipes and #Parabacteroides and lower #Prevotella; BD by higher #Bifidobacterium and #Oscillibacter; and SZ by higher #Prevotella and lower #Bacteroides, #Haemophilus, and #Streptococcus - Higher caffeine and #Coffee intake was related to higher alpha diversity higher relative abundance of #Faecalibacterium and Alistipes, and lower relative abundance of #Erysipelatoclostridium. - After adjustment of vitamin B2 in multivariate analysis, the significant inverse association between #Erysipelatoclostridium count and caffeine intake remained statistically significant. [1.11] [#Aging] - the loss of #Lactobacillus and #Faecalibacterium, as well as the abundance of #Oscillibacter and Alistipes genera along with the #Eubacteriaceae family is linked to #Frailty in elderly people. [1.12] - in neurodegenerative disease > The microbes with elevated populations, like #Bilophila, Butryicicoccus, Alistipes, #Enterococcus, #Lactobacillus, #Streptococcus, #Shigella, and #Desulfovibrio, have the metabolic capability to produce #Putrescine majorly by the #Putrescine III biosynthesis pathway. [1.13] - strains that are similar to Alistipes sp. CAG:514 are known to produce #GABA. [#Alzheimer’s disease, #Cognitive impairment, #Mild Cognitive Impairment] [#Mediterranean Ketogen Diet] - Participants with MCI on the MMKD had lower levels of #GABA-producing microbes Alistipes sp. CAG:514 and #GABA, and higher levels of #GABA-regulating microbes #Akkermansia muciniphila. [#American Heart Association Diet] - the low-fat AHAD modulates key #Neurotransmitters, such as promoting #GABA production, in individuals with #Cognitive impairment. This dysregulation may be related to increases in #GABA-producing microbes, such as Alistipes sp. CAG:514. [1.14] [#Vogt-Koyanagi-Harada] - An enriched Alistipes along with a lower level of #Dorea were observed in VKH patients. [1.15] [#Alzheimer’s disease] - Increased proportions of #Bacteroides, Alistipes, #Odoribacter, and #Barnesiella and decreased proportions of #Lachnoclostridium were present in AD elders. [1.16] [#Alzheimer’s disease] - Alistipes, #Barnesiella, and #Odoribacter were previously found in symptomatic individuals with AD. [1.17] - Other genera in the #Bacteroidetes phyla are Alistipes, #Anaerorhabdus, #Dichelobacter, #Fibrobacter, #Megamonas, #Mitsuokella, #Rikenella, #Sebaldella, #Tannerella, and #Tissierella. [1.18] [#Metabolic associated fatty liver disease] - An increase in #Dorea, combined with decreases in Alistipes appears to be characteristic of MAFLD patients. [#Metabolic associated fatty liver disease] - #Ruminococcus obeum and Alistipes were most enriched in healthy individuals when compared with MAFLD patients. [#Metabolic associated fatty liver disease] - In MAFLD > Alistipes has negatively related to serum #Glucose (GLU), gamma-glutamyl transferase (GGT), and alanine aminotransferase (ALT). [1.19] [#Animal-based diet] - increased #Animal protein intake is associated with increased relative abundance of Alistipes and #Bacteroides genera - abundance of #Enterobacteriaceae and Alistipes was increased, and #Faecalibacterium abundance was decreased in patients with #Major depressive disorder [1.21] - increased #Animal protein intake is associated with increased relative abundance of Alistipes and #Bacteroides genera [1.22] [#Short Chain Fatty Acid] - increased abundance of gut ##Ruminococcus and #Alistipes in castration-resistant #Prostate cancer (CRPC) patients along with ##Bacteroidales, ##Rikenellaceae, ##Faecalibacterium,the so called SCFAs-producing microbiotas. [#Prostate cancer] [#Short Chain Fatty Acid] - FMT with CRPC patients’ fecal suspension > increase SCFAs-producing gut microbiotas such as #Ruminococcus, Alistipes, Phascolarctobaterium in TRAMP, and correspondingly raised their gut SCFAs (#Acetate and ##Butyrate) levels. [1.23] - In patients with #Psoriatic Arthritis, there was a decrease in the abundance of certain bacteria such as #Akkermansia, #Ruminococcus, #Pseudobotyrivibrio, #Paraacteroides, Alistipes, and #Coprococcus [1.24] [#Prostate cancer] - #Anaerofilum is protective because it reduces inflammation caused by Alistipes, which produce pro-inflammatory mediators and raise the risk of PCA [#Prostate cancer] [#Short Chain Fatty Acid] - #Subdoligranulum, #Lachnobacterium, #Christensenellaceae, #Lachnospira, #Rikenellaceae, #Eggerthella, and Alistipes are members of the SCFA-producing order #Clostridiales and were shown to be more prevalent in individuals with high-grade PCA. [1.25] - #Ginger essential oil supplementation in PL mice enhanced the relative abundance of #Lactobacillus, Alistipes, and #Olsenella, which are considered beneficial bacteria. [#Metabolic Dysfunction-associated Steatohepatitis] [#Short Chain Fatty Acid] - Alistipes, which are potential SCFA-producing bacteria that reduce hepatic fibrotic conditions through cytokine modulation, have been found at lower levels in the guts of NASH and NASH-#Cirrhosis patients [1.26] [#Parkinson’s Disease] [#Fiber-free diet, #Low fibre Diet] - The lack of dietary fiber makes specialized taxa, which are equipped with glycan-degrading enzymes, such as #Akkermansia spp. or the Bacteriodetes genera Alistipes spp. and #Bacteroides spp.,65 switch to host #Glycans as energy resource, promoting mucus erosion and pathogens susceptibility. [1.27] [#Clostridium cluster IV] - the species showing strong correlations with steroid hormone biosynthesis, including Alistipes, #Clostridium IV and #Tannerella, might contribute to the transformation of steroidal hormones by their metabolic products. - Alistipes was associated with the level of bile acid, influencing portal #Hypertension though farnesoid-X receptor - Alistipes might affect the host #Hypertension via bile acid metabolism. - the strong negative correlation between Alistipes and steroid hormone biosynthesis may suggest that Alistipes could reduce the BP by regulating steroid hormone biosynthesis, which is associated with #Hypertension [#Hypertension] - The probiotics-reduced BP was associated with the increased #Lawsonia and #Pyrolobus and reduced Alistipes and #Alloprevotella. [#Hypertension] [#Bifidobacterium animalis lactis] - the decreased level of Alistipes induced by B. lactis M8 was correlated with the reduced level of BP, consistent with previous reports that Alistipes was positively correlated with BP [#Probiotic] - the probiotics reduced the abundance of Alistipes and increased the level of #Pyrolobus, which is associated with lipid and vitamin metabolism, subsequently attenuating the development of #Hypertension. [1.28] [#Kidney stone] - the majority of genes significantly enriched in non-stone formers are affiliated with #Faecalibacterium prausnitzii, a major #Butyrate producer and the majority of abundant genes mapped back to F. prausnitzii, Alistipes spp., and #Akkermansia muciniphila. [1.29] [#Diabetes Type 2] - IR and faecal monosaccharides were lower in individuals who harboured more #Bacteroidales-type #Bacteria in their gut, potentially highlighting the role of #Bacteroidales-type #Bacteria (#Bacteroides, Alistipes) in mediating IS.References Notes (1) [1.86]
