Oscillospiraceae ⇒ Oscillibacter {10000281}

Shared Reference Notes

• [1.1] 
  - Increased relative abundances of fecal Oscillibacter and #Alistipes > causally linked to decreased #Triglyceride concentration.
• [1.2] [#Diabetes Type 2] [#Coprococcus etes] 
  - There are 36 different strains of #Butyrate-producing bacteria, and five of them are associated with increased insulin sensitivity: #Coprococcus etes, Oscillibacter sp. CAG 241, #Alistipes finegoldi and #Faecalibacterium prausnitzii. - The genus #Coprococcus was associated with higher insulin sensitivity and disposition index and a lower rate of dysglycemia.
• [1.3] [#Bipolar disorder, #Major depressive disorder, #Schizophrenia] 
  - MDD was often characterized by higher #Alistipes and #Parabacteroides and lower #Prevotella; BD by higher #Bifidobacterium and Oscillibacter; and SZ by higher #Prevotella and lower #Bacteroides, #Haemophilus, and #Streptococcus
• [#Bipolar disorder] [#kynurenic acid] - there is an inverse relationship between Oscillibacter (a genera increased in patients with BD) and the levels of #Tryptophan and KYNA.
• [1.4] [#Aging] 
  - the loss of #Lactobacillus and #Faecalibacterium, as well as the abundance of Oscillibacter and #Alistipes genera along with the #Eubacteriaceae family is linked to #Frailty in elderly people.
• [1.5] [#Obesity] [#Physical activity] 
  - In overweight > high PA duration > participants had a lower abundance of the Oscillibacter genus.
• [1.6] 
  - #Lachnospira pectinoschiza, #Eubacterium eligans, and likely the uncharacterized Oscillibacter are #Butyrate producers
• [1.7] [#High Fat Diet] 
  - Oscillibacter spp. were correlated with decreased colonic epithelial integrity in the context of a high-fat diet in mice
• [1.8] [#Obesity] 
  - Oscillibacter contained genes encoding proteins with high sequence identity to lipoprotein synthesis pathway proteins responsible for synthesizing lipoprotein, a TLR2 agonist, along with #Flagellin synthesis and assembly machinery proteins responsible for synthesizing #Flagellin, a TLR5 agonist
• [1.9] [#CVD, #Hypercholesterolaemia, #Hyperlipidemia] 
  - Species from the Oscillibacter genus were associated with decreased fecal and plasma #Cholesterol levels. - human gut Oscillibacter isolates > conserved #Cholesterol-metabolizing capabilities, including glycosylation and dehydrogenation. - #Cholesterol metabolism is a broad property of phylogenetically diverse Oscillibacter spp.

References Notes