Lachnospiraceae ⇒ Anaerostipes {10000836}

Shared Reference Notes

• [1.1] [#Diabetes Type 2] 
  - Anaerostipes is positively associated with type 2 diabetes. Similarly, in studies of type 1 diabetes and gestational diabetes, Parabacteroides was elevated compared to healthy controls.
• [1.2] [#Diabetes Type 2] 
  - Low levels of Anaerostipes > improved glucose tolerance and reduced plasma triglyceride levels in mice
• [1.3] [#Diabetes Type 1] [#Lipopolysaccharide] 
  - lipopolysaccharides biosynthesis in #Bacteroides MAGs (metagenome-assembled genomes) and #Sulfate reduction in Anaerostipes MAGs as functional signatures of MAGs with positive IA-association (Islets autoantibody)
• [1.4] [#Multiple Sclerosis] 
  - Faecalibacteria, #Lachnospiraceae, and Anaerostipes produce butyrate, which acts via G-protein coupled receptors activation and histone deacetylase inhibition to suppress CNS demyelination, the main pathological feature in MS.
• [1.5] [#Crohn’s disease] [#Clostridium cluster IV] 
  - #Roseburia, #Gemmiger, #Coprococcus, #Ruminococcus 2, #Butyricicoccus, #Dorea, #Fusicatenibacter, Anaerostipes, Clostridium IV were enriched in the healthy controls. - #Blautia, Clostridium IV, #Coprococcus, #Dorea, #Fusicatenibacter continued to significantly decrease in early and advanced CD patients, and Escherichia/Shigella and Proteus continued to significantly increase. - negative correlation between #Dorea, #Butyricicoccus, #Roseburia and gland reduce, #Roseburia and FC, #Butyricicoccus and goblet cells decreased, Parabacterodies and sex, Clostridium IV and CRP, #Dorea and ESR . - positive correlation between Escherichia/Shigella and CRP, #Ruminococcus 2 and clinical symptoms.
• [1.6] [#Diabetes Type 2] 
  - A significant reduction of genera #Alistipes, Anaerostipes, #Ruminococcus was detected in the T2D group.
• [1.7] 
  - #Inulin > increase genera #Blautia, Anaerostipes, and #Bifidobacterium

References Notes