Lachnospiraceae ⇒ Anaerostipes {10000836}

Shared Reference Notes

• [1.1] [#Diabetes Type 2] 
  - Anaerostipes is positively associated with type 2 diabetes. Similarly, in studies of type 1 diabetes and gestational diabetes, Parabacteroides was elevated compared to healthy controls.
• [1.2] [#Diabetes Type 2] 
  - Low levels of Anaerostipes > improved glucose tolerance and reduced plasma triglyceride levels in mice
• [1.3] [#Diabetes Type 1] [#Lipopolysaccharide] 
  - lipopolysaccharides biosynthesis in #Bacteroides MAGs (metagenome-assembled genomes) and #Sulfate reduction in Anaerostipes MAGs as functional signatures of MAGs with positive IA-association (Islets autoantibody)
• [1.4] [#Multiple Sclerosis] 
  - Faecalibacteria, #Lachnospiraceae, and Anaerostipes produce butyrate, which acts via G-protein coupled receptors activation and histone deacetylase inhibition to suppress CNS demyelination, the main pathological feature in MS.
• [1.5] [#Crohn’s disease] [#Clostridium cluster IV] 
  - #Roseburia, #Gemmiger, #Coprococcus, #Ruminococcus 2, #Butyricicoccus, #Dorea, #Fusicatenibacter, Anaerostipes, Clostridium IV were enriched in the healthy controls. - #Blautia, Clostridium IV, #Coprococcus, #Dorea, #Fusicatenibacter continued to significantly decrease in early and advanced CD patients, and Escherichia/Shigella and Proteus continued to significantly increase. - negative correlation between #Dorea, #Butyricicoccus, #Roseburia and gland reduce, #Roseburia and FC, #Butyricicoccus and goblet cells decreased, Parabacterodies and sex, Clostridium IV and CRP, #Dorea and ESR . - positive correlation between Escherichia/Shigella and CRP, #Ruminococcus 2 and clinical symptoms.
• [1.6] [#Diabetes Type 2] 
  - A significant reduction of genera #Alistipes, Anaerostipes, #Ruminococcus was detected in the T2D group.
• [1.7] 
  - #Inulin > increase genera #Blautia, Anaerostipes, and #Bifidobacterium
• [1.8] [#Acute lymphoblastic leukemia] 
  - #Roseburia, #Dialister, #Prevotella, #Faecalibacterium and Anaerostipes showed reduced relative abundance in #Children with ALL at the time of diagnosis
• [#Polysaccharide] - #Cessation of breastfeeding initiates the transition towards an #Adult-like gut microbiome composition, which is characterized by expansion of #Roseburia spp. and Anaerostipes spp., restriction of #Lactobacillus spp. and a functional shift towards an increased capacity to degrade complex polysaccharides
• [1.9] [#Bacteroides-Prevotella group] 
  - only #Faecalibacterium, but not #Blautia, Anaerostipes, or #Megamonas, was significantly lower in the #Hypertension group
• [#Attention Deficit Hyperactivity Disorder] - higher abundance of three genera (#Agathobacter, Anaerostipes, and #Lachnospira) and decreased levels of TNF-α in the ADHD
• [1.11] 
  - patients with #Celiac Disease showed the abundance of #Streptococcus, #Lactobacillus, #Veillonella, and #Allisonella species, while the abundance of #Ruminococcus, #Faecalibacterium, #Blautia, #Gemmiger, and Anaerostipes was decreased.
• [1.12] [#Multiple Sclerosis] 
  - Individuals with relapsing-remitting MS have an abundance of #Mycoplasma, #Pseudomonas, #Faecalibacterium, #Haemophilus, Anaerostipes, #Blautia, and #Dorea, while #Bacteroides, #Prevotella, #Parabacteroides, and #Adlercreutzia are relatively less common.
• [1.13] [#Omega 3] 
  - omega-3 rich diet has been shown to result in a significant increase in #Subdoligranulum, along with other #Butyrate producers like Anaerostipes, #Coprococcus, and #Roseburia.
• [#Juvenile idiopathic arthritis] [#Roseburia hominis] - In JIA > reduced Anaerostipes, #Dialister, #Lachnospira, and #Roseburia have been correlated with rheumatic clinical indices including antibodies, erythrocyte sedimentation rate (ESR) and clinical JIA disease activity score. - #Dialister, #Lachnospira, and #Roseburia (#Roseburia hominis in 0% of ABISJIA) were three of five genera reduced in ABISJIA, as well as an ASV belonging to Anaerostipes.
• [1.14] 
  - P-#Inulin administration altered the composition of the gut microbiota significantly, with an increase in abundance of #Bifidobacterium and Anaerostipes > significant enrichment in microbial metabolites derived from saccharolysis.
• [1.15] [#Acetic acid, #Butyric acid] 
  - Anaerostipes, a group of Gram-variable specialized anaerobes, are known for their production of acetic and butyric acids
• [#Inositol Lipids] - significant proportion of Anaerostipes species tested have the ability to convert inositol into #Propionate, potentially offering advantageous effects on health
• [#Diabetes Type 2] - An increased presence of Anaerostipes in the gut microbiota has been linked to an enhancement in glomerular filtration rate and a positive impact on renal function. - Individuals with type 2 diabetes exhibit a decreased abundance of Anaerostipes in their gut compared to those in good health
• [#Short Chain Fatty Acid] - SCFA-producing #Bacteria such as #Akkermansia, #Butyrivibrio, #Holdemania, Anaerostipes, and #Intestinimonas were identified in this study as part of the gut microbiota associated with #Hypothyroidism. - SCFAs play a crucial role in the regulation of sodium/#Iodine symporter (NIS) expression in thyroid cells.
• - #Akkermansia, #Butyrivibrio, #Holdemania, and #Ruminococcaceae UCG-011 were identified as protective factors for #Hypothyroidism, whereas Anaerostipes, #Intestinimonas, and Ruminiclostridium5 were found to have negative effects on the condition.
• [1.16] [#Diabetes Type 2] 
  - #Blautia, #Faecalibacterium, #Bifidobacterium, #Clostridium, Anaerostipes, #Mediterraneibacter, and #Butyricicoccus abundances were relatively higher in healthy fecal samples than in prediabetic fecal samples.

References Notes