Microbiome & Chronic Diseases

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Streptococcus ⇒ Streptococcus mutans {10000548}

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Streptococcus mutans


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Shared Reference Notes

  • [1.1] [#Parkinson’s Disease
    - At one end of the spectrum, #Bifidobacterium dentium was elevated by 7-fold, #Actinomyces oris by 6.5-fold, Streptococcus mutans by 6-fold. At the other end of the spectrum, #Roseburia intestinalis was reduced by 7.5-fold, and #Blautia wexlerae by 5-fold.
  • [1.2] [#Cerebral microbleeds (CMBs)
    - Cerebral microbleeds (CMBs) influence long-term prognoses of #Stroke patients. - Streptococcus mutans, a major cariogenic bacterium that expresses the collagen-binding protein Cnm, induces cerebrovascular inflammation, impairing blood brain barrier integrity and causing cerebral bleeding.
  • [1.3] [#Diabetes Type 2] [#Imidazole propionate
    - Imidazole propionates (ImP), produced by several bacterial strains, including Streptococcus mutans and #Eggerthella lenta, which was found to be elevated in individuals with T2DM and impairs insulin signaling through activation of the p38γ-p62-mTORC1 pathway
  • [1.4
    - oral #Lantibiotics (it has a considerable antimicrobial effect on intestinal gram-positive bacteria) produced by S. mutans decrease the diversity of intestinal microbes and reduce the abundance of #Firmicutes
  • [#Streptococcus pneumoniae, #Streptococcus salivarius] - Two-group pheromone-based subsystem BlpRH is the core node coordinating bacteriocin production and integrating signals of competence activation cascade, typically for S. pneumoniae and S. mutans. - Human co-salivary Streptococcus lacks functional BlpRH pairs, the couples bacteriocin production and competence commitment is directly guided by the competence signaling system ComRS, which is the undetermined basis for its optimal adaptation, potentially explaining the high prevalence of S. salivarius in the human GI tract

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Common References