Disease ⇒ Chronic kidney disease {40000186}

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Chronic kidney disease


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Shared Reference Notes

  • [1.1
    - In chronic kidney disease (CKD), the “healthy” microbiota structure is disrupted, and intestinal microbes produce large quantities of uremic solutes responsible for renal damage; on the other hand, the uremic state, fueled by reduced renal clearance, causes shifts in microbial metabolism and composition, hence creating a vicious cycle in which dysbiosis and renal dysfunction are progressively worsened.
  • [1.2
    - Saccharibacteria (per 1-SD higher in the log-transformed abundance) could potentially decrease the concentration of serum creatinine and increase the estimated glomerular filtration rate which might help improve renal function.
  • [1.3] [#Uremic toxins
  • [1.4
    - #Curcumin > significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-γ, and IL-4) and lipid peroxidation. - After 6 months of #Curcumin supplementation > significantly lower #Escherichia-#Shigella and significantly higher #Lachnoclostridium . - In the last 3 months of supplementation > significantly higher #Lactobacillaceae spp..
  • [1.5
    - Bacterial species involved in #Butyrate production, #Indole synthesis and mucin degradation were also related to CKD.
  • [1.6
    - Chronic kidney disease > decreased #Indole, #Indole-3-carboxaldehyde and #Indole-3-propionic acid
  • [1.7] [#Aging
    - #Hippuric acid has been found increased in patients with chronic kidney disease and several age-related conditions
  • [1.8
  • [1.9
    - #Hydrogen sulfide (H2S) and methanethiol are produced during the decomposition of #Sulfur-containing amino acids, and have been linked to the progression of chronic kidney disease (CKD), cardiovascular disease, and bone metabolic disorders
  • - #Butyrate can protect glomerular endothelial cells against mitochondrial dysfunction.
  • [#Short Chain Fatty Acid] - fecal and serum SCFAs are remarkably higher in healthy controls than in patients affected by CKD. - the progression of CKD negatively correlates with the amount of #Butyrate detected in the serum of the patients. - #Butyrate supplementation might have potential beneficial effects on kidney function
  • - In CKD patients, the concentrations of microbiota-derived trimethylamine N-oxide (#TMAO), indoxyl #Sulfate and p-cresyl #Sulfate in the blood are increased. Because of poor renal function in CKD patients, these #Uremic toxins remain in the circulation, promote inflammation, thereby contributing to progressive kidney injury.

References Notes

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Common References

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