Bile Acids ⇒ Glycoursodeoxycholic acid {90000409} Record Keys Parent:Bile Acids Definition:Glycoursodeoxycholic acid Queue:[ ] Details Initialisation date:[ ] Specification: GUDCASource: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Diabetes Type 2] [#Oral administration of Metformin] - GUDCA, an endogenous bile acid conversed by gut bacteria, was found to be increased by metformin treatment and improve insulin sensitivity though an intestinal FXR dependent pathway [1.2] [#Anorexia nervosa, #Bulimia nervosa] [#Bacteroides uniformis] - Individuals with AN lacking the genomic region of B. uniformis had greater scores for self-denial and bulimia. - The genetic deletion in B. uniformis could result in the deficiency of thiamine, a vitamin associated with intestinal and mental health. - The #Serotonin synthesis module causally affected BMI through glycoursodeoxycholic acid, which is upregulated by #Serotonin. [1.3] [#Biliary tract cancer, #Intrahepatic Cholangiocarcinoma, #Primary liver cancer] - enriched in ICC were #Actinomyces, #Lactobacillus, #Peptostreptococcaceae, and #Alloscardovia. Furthermore, the glycoursodeoxycholic acid and #Tauroursodeoxycholic acid (TUDCA) plasma-stool ratios were significantly increased in ICC with the genera #Lactobacillus and #Alloscardovia exhibiting positive correlations with the TUDCA plasma-stool ratio. - These biomarkers could be used to differentiate ICC from hepatocellular carcinoma (HCC)References Notes[ ]
