Vitamin B12 {90000185}

Shared Reference Notes

• [1.1] [#Dementia] 
  - Low B-12 not only causes central nervous system (CNS) damage by decreasing availability of methyl groups, but also allows accumulation of homocysteine, which appears to be toxic to nerve cells and blocks N-methyl-dasparate receptors. - It is also important to remember that for B-12 by itself to be functional, it needs to be converted to glutathionyl cobalamin, which requires glutathione for its synthesis. Oxidative stress can tie up glutathione and contribute further to lack of B-12 function.
• [1.2] 
  - Vitamin B12 deficiency at the brain level is associated with affective disorders, behavior changes, psychosis, cognitive impairment or decline, and #Dementia (including #Alzheimer’s disease and vascular #Dementia protection)
• - Treatment with vitamin B12 in rats with experimental #Autism improved impaired markers of this neurologic condition
• [#Covid-19] - Methylcobalamin has a significant affinity to bind to the active site of the nsp12 protein of SARS-CoV-2, Thus, vitamin B12 may inhibit the RNA‐dependent RNA polymerase activity of nsp12 responsible for the replication of the viral genome.
• - The neurologic complications of B12 deficiency occur at a later stage of depletion and was associated with severe symptoms of #Depression, suicidal behaviors, reduced cognition, mental #Fatigue, bad or depressed moods, mania, psychosis, and intense agitation
• - Bacterial vitamin B12 is synthesized by the gut-resident Propionibacterium Freudenreichii, Lactobacillus reuteri, L.coryniformis, L. plantarum, Bifidobacterium animalis, B. infantis, and B. longum, among others, to produce adenosylcobalamin. -resident bacteria in the colon produce cobalamin, which regulates gene expression in gut Bacteroidetes. - severe vitamin B12 deficiency can also be associated with increased risk and severity of infections, because this deficiency affects the functions of phagocytes, production of interferon, replication of viruses, and maturation of T lymphocytes. - some scientists claim that natural methylcobalamin and adenosylcobalamin forms may have greater vitamin B12 activity than the synthetic cyanocobalamin form

References Notes