Vitamin B12 {90000185}
| Biotic: | Vitamin B12 |
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| Parent: | [ ] |
| Queue: | [ ] |
| Initialisation date: | 2021-06-30 |
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| Specification: | |
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| Source: | |
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| Structural Type: | [ ] |
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| Functional Type: | Vitamin |
| Function: | Neurodevelopment |
Notes:
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References Notes
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Shared Reference Notes
- [1.1]
- Low B-12 not only causes central nervous system (CNS) damage by decreasing availability of methyl groups, but also allows accumulation of homocysteine, which appears to be toxic to nerve cells and blocks N-methyl-dasparate receptors.
- It is also important to remember that for B-12 by itself to be functional, it needs to be converted to glutathionyl cobalamin, which requires glutathione for its synthesis. Oxidative stress can tie up glutathione and contribute further to lack of B-12 function.