Fiber-free diet {51111190}

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Fiber-free diet
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Shared Reference Notes

  • [1.1
    - The fiber-free diet had adapted the microbiome to a metabolism of simple carbohydrates. - The growth of Firmicutes bacteria is promoted, which in addition to carbohydrate metabolism are also capable of amino acid metabolism. The fecal amino acid level was changed, which could also be seen in the amount of microbial amino acid metabolites.
  • [1.2] [#Low fibre Diet
    - the lowest levels of tight junction proteins #ZO-1 and #Occludin in TG mice challenged by fiber deprivation and #Curli.
  • [#Low fibre Diet] - Longer-term lack of dietary fiber triggers a compensatory mechanism, increasing mucin production, and re-establishing at least the inner mucus thickness.
  • [#Lachnospiraceae] - The lack of dietary fiber > reduced abundances of the #Butyrate-producing genera Lachnospiraceaea NK4A136 and #Roseburia. Additionally, #Lactobacillus, which was also reduced in Fibre deprived mice
  • [#Parkinson’s Disease] [#Low fibre Diet] - The lack of dietary fiber makes specialized taxa, which are equipped with glycan-degrading enzymes, such as #Akkermansia spp. or the Bacteriodetes genera #Alistipes spp. and #Bacteroides spp.,65 switch to host #Glycans as energy resource, promoting mucus erosion and pathogens susceptibility.
  • [#Parkinson’s Disease] [#Escherichia coli] [#Alpha-synuclein] - oral administration of E. coli to αSyn-overexpressing mice exacerbates PD-like pathologies, such as phosphorylated αSyn-positive structures and neurodegeneration, which are more pronounced in mice fed an FD diet.

References Notes

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