Disease
Microbiota ☳
Metabolome
Factor
Enterobacteriaceae ⇒ Klebsiella {10000103}
Record Keys
Parent:
Definition: Klebsiella
Details
Initialisation date: 2020-09-06
Meta Information
Rank:
Domain:
Zone: [ ]
Enzyme: [ ]
Function: [ ]
Notes: Shared Reference Notes
[1.1 ] Klebsiella can colonize the gut and result in severe gut inflammation in susceptible individuals, thereby exacerbating inflammatory disease
[1.2 ] [#Premature infant ] Klebsiella overgrowth in the gut is highly predictive for brain damage in permature infants and is associated with a pro-inflammatory immunological tone.
[1.3 ] [#Parkinson’s Disease ] [#Lipopolysaccharide ] #Prevotella copri , which interestingly, produces an LPS that not only does not induce inflammation, but can inhibit TLR4 activation by others.
- Eleven of the 55 species that are enriched in PD are canonical Gram-negative organisms including those with highly stimulatory LPS (#Escherichia coli , Klebsiella species, and #Porphyromonas asaccharolytica ).
[1.4 ] Klebsiella species was significantly higher in patients with #Crohn’s disease and #Primary sclerosing cholangitis when compared with healthy controls.
- Several genes increased in the faecal microbiomes of patients with inflammatory bowel diseases > include hemolysin-coregulated protein and enzymes involved in fructose-, galactitol-, mannose-, and long-chain fatty acid-related uptake and metabolic pathways- were enriched in most faecal samples of the patients with inflammatory disease who carried Klebsiella species.
Intervention in Disease
Author: MetaBiomIdentifier: 10000103URL: https://www.metabiom.org/microbiota/2/klebsiellaKeywords: Microbiome, Dysbiosis, Microbiota, Organism, Bacteria
Common References
[1.1 ] Ectopic gut colonization: a metagenomic study of the oral and gut microbiome in Crohn’s disease 80001846 ]
[1.2 ] Aberrant gut-microbiota-immune-brain axis development in premature neonates with brain damage 80002063 ]
[1.3 ] Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms 80002696 ]
[1.4 ] Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation 80000027 ]
[1.5 ] Skin microbiome differences relate to the grade of acne vulgaris 80001179 ]
[1.6 ] Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption 80001029 ]
[1.7 ] The airway microbiome in patients with severe asthma: associations with disease features and severity 80000408 ]
[1.8 ] The gut microbiome in atherosclerotic cardiovascular disease 80000614 ]
[1.9 ] Alterations of gut microbiome in autoimmune hepatitis 80001159 ]
[1.10 ] Gut microbial profile in biliary atresia: a case-control study 80001225 ]
[1.11 ] Duodenal and faecal microbiota of celiac children: molecular, phenotype and metabolome characterization. 80000529 ]
[1.12 ] Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease 80000791 ]
[1.13 ] Composition of gut microbiota in patients with toxigenic Clostridioides (Clostridium) difficile: Comparison between subgroups according to clinical criteria and toxin gene load 80001022 ]
[1.14 ] Human intestinal lumen and mucosa-associated microbiota in patients with colorectal cancer 80000305 ]
[1.15 ] Alterations in the gut microbiome and metabolism with coronary artery disease severity_DUBLICATE 80001002 ]
[1.16 ] Inflammation-related differences in mucosa-associated microbiota and intestinal barrier function in colonic Crohn’s disease 80000896 ]
[1.17 ] Relationship between alterations of urinary microbiota and cultured negative lower urinary tract symptoms in female type 2 diabetes patients 80001099 ]
[1.18 ] Intestinal microbiota is altered in patients with gastric cancer from Shanxi Province, China 80001028 ]
[1.19 ] Dysbiosis of fecal microbiota and high frequency of Citrobacter, Klebsiella spp., and Actinomycetes in patients with irritable bowel syndrome and gastroenteritis 80000589 ]
[1.20 ] Microbiome and its relation to gestational diabetes 80000966 ]
[1.21 ] Gut microbiome alterations in hereditary angioedema 80002296 ]
[1.22 ] Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism 80000345 ]
[1.23 ] Gut microbiota dysbiosis contributes to the development of hypertension 80000033 ]
[1.24 ] Molecular assessment of differences in the duodenal microbiome in subjects with irritable bowel syndrome 80000415 ]
[1.25 ] Microbiome analytics of the gut microbiota in patients with juvenile idiopathic arthritis: a longitudinal observational cohort study 80001040 ]
[1.26 ] Characterization of microbiota in male infertility cases uncovers differences in seminal hyperviscosity and oligoasthenoteratozoospermia possibly correlated with increased prevalence of infectious bacteria 80000723 ]
[1.27 ] A microbiome case-control study of recurrent acute otitis media identified potentially protective bacterial genera 80000688 ]
[1.28 ] Gut microbial profile analysis by MiSeq sequencing of pancreatic carcinoma patients in China 80000728 ]
[1.29 ] Alteration of the fecal microbiota in Chinese patients with Parkinson’s disease 80000645 ]
[1.30 ] Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy 80000594 ]
[1.31 ] Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis 80000583 ]
[1.32 ] Faecal microbiota study reveals specific dysbiosis in spondyloarthritis 80000813 ]
[1.33 ] Analysis of gut microbiota diversity and auxiliary diagnosis as a biomarker in patients with schizophrenia: a cross-sectional study 80000800 ]
[1.34 ] The bacterial communities of the small intestine and stool in children with short bowel syndrome 80001208 ]
[1.35 ] Fecal microbiota signatures of adult patients with different types of short bowel syndrome 80000662 ]
[1.36 ] Alterations of the gut microbiome in Chinese patients with systemic lupus erythematosus 80000460 ]
[1.37 ] Alterations in the gut microbiota and metabolite profiles of thyroid carcinoma patients 80000975 ]
[1.38 ] Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis. 80000612 ]
[1.39 ] Skin microbiome differences in atopic dermatitis and healthy controls in Egyptian children and adults, and association with serum immunoglobulin E 80001201 ]
[1.40 ] Altered intestinal microbiota associated with colorectal cancer 80001232 ]
[1.41 ] Fungal dysbiosis in mucosa-associated microbiota of Crohn’s disease patients 80000760 ]
[1.42 ] Dysbiosis of urinary microbiota is positively correlated with type 2 diabetes mellitus 80000429 ]
[1.43 ] Analysis of by high-throughput sequencing: Helicobacter pylori infection and salivary microbiome 80001404 ]
[1.44 ] Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma 80000859 ]
[1.45 ] Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure 80000785 ]
[1.46 ] Altered gut microbiota composition associated with eczema in infants 80000741 ]
[1.47 ] Alterations in the gut bacterial microbiome in fungal keratitis patients 80000884 ]
[1.48 ] Intestinal microbial ecology in premature infants assessed with non-culture-based techniques 80001077 ]
[1.49 ] The association between gut microbiota composition and body mass index in Chinese male college students, as analyzed by next-generation sequencing 80001120 ]
[1.50 ] Alterations of urinary microbiota in type 2 Diabetes Mellitus with hypertension and/or hyperlipidemia 80000661 ]
[1.51 ] Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery 80002685 ]
