Enterobacteriaceae ⇒ Klebsiella {10000103}

Shared Reference Notes

• [1.1] [#Hypertension] 
  - Elevated putative #Succinate-producing bacteria and #Acetate-producing bacteria > respectively, lower and higher mean arterial pressure in mouse - #Prevotella and Klebsiella > overrepresented in individuals with pHTN or HTN.
• [1.2] 
  - Oral Klebsiella can colonize the gut and result in severe gut inflammation in susceptible individuals, thereby exacerbating inflammatory disease
• [1.3] [#Biliary tract cancer] 
  - The predominant dysbiotic bacteria in both #Chronic cholecystitis and gallbladder #Cancer were those belonging to the #Enterobacteriaceae family. Klebsiella increased significantly in the order of normal, #Chronic cholecystitis, and gallbladder #Cancer.
• [1.4] [#Premature infant] 
  - Klebsiella overgrowth in the gut is highly predictive for brain damage in permature infants and is associated with a pro-inflammatory immunological tone.
• [1.5] [#Parkinson’s Disease] [#Lipopolysaccharide] 
  - of the 29 species that are reduced in PD, only 1 is a canonical Gram-negative organism, #Prevotella copri, which interestingly, produces an LPS that not only does not induce inflammation, but can inhibit TLR4 activation by others. - Eleven of the 55 species that are enriched in PD are canonical Gram-negative organisms including those with highly stimulatory LPS (#Escherichia coli, Klebsiella species, and #Porphyromonas asaccharolytica).
• [1.6] 
  - The aggregated relative abundance of Klebsiella species was significantly higher in patients with #Crohn’s disease and #Primary sclerosing cholangitis when compared with healthy controls. - Several genes increased in the faecal microbiomes of patients with inflammatory bowel diseases > include hemolysin-coregulated protein and enzymes involved in fructose-, galactitol-, mannose-, and long-chain fatty acid-related uptake and metabolic pathways- were enriched in most faecal samples of the patients with inflammatory disease who carried Klebsiella species.
• [1.7] [#Cesarean section] 
  - #Children born by C-section demonstrate reduced colonization stability of #Bacteroides by day 14 and reduced abundance throughout infancy and up to 5 years of life. - The low-#Bacteroides profile of neonates delivered by C-section is accompanied by an increased relative abundance of opportunistic pathogens (for example, #Enterococcus spp. and Klebsiella spp.)
• [1.8] [#Human breast milk, #Vaginally delivery] 
  - At 6 weeks postpartum, the composition and structure of gut microbiota of #Cesarean section-delivered (CSD) #Infants differed from those of vaginally delivered (VD) #Infants, with decreased #Bacteroides and #Escherichia-#Shigella and increased Klebsiella, #Veillonella, and #Enterococcus. - At 6 months postpartum, these delivery mode-induced microbial shifts were restored by exclusive breastfeeding, resulting in similar gut microbial profiles between VD and CSD #Infants who were exclusively breastfed and more variable gut microbial profiles between VD and CSD #Infants who were mixed fed.
• [1.9] 
  - #Bifidobacterium, #Slackia, #Enterococcus, Thiococcus, Klebsiella, #Serratia, and #Enterobacter abundances were also decreased with #Vitamin B6 supplementation in #Lactose-intolerant patients .
• - #Sulfur-metabolism pathways were found to be one of the frequent pathways among certain member of #Cancer-increased taxa such as #Aquabacterium, #Bilophila wadsworthia, #Delftia, #Desulfovibrio, #Escherichia coli, #Fusobacterium, Klebsiella, #Lactobacillus, #Morganella, #Odoribacter, and #Proteus.
• [1.11] 
  - #Hydrogen sulfide may suppress the #Oxygen-dependent metabolism of some pathogens - #Taurinivorans muris has a protective role against Klebsiella and #Salmonella, two important gut pathogens.
• [1.12] 
  - levels of #TMAO in cystic fluid were positively correlated with bacterial clusters corresponding to Enterobacteriacea, #Granulicatella, Klebsiella, #Stenotrophomonas, #Streptococcus, #Haemophilus, and #Fusobacterium > associated with #Pancreatic Cancer.
• [1.13] 
  - Patients with #Primary biliary cirrhosis were found to show enrichment of #Actinobacteria, #Lactobacillales, #Streptococcus, Klebsiella and #Veillonella
• [1.14] 
  - higher incidence of the genus Klebsiella in the urine of female patients with #Bladder cancer.
• [1.15] [#Alcohol Consumption] 
  - Klebsiella on skin was positively associated with metabolites of alcohol. - alcohol intake may change the host into a Klebsiella-tolerant environment, resulting in the adaptation and expansion of pathogenic Klebsiella

References Notes