Microbiome & Chronic Diseases

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Enterobacteriaceae ⇒ Klebsiella {10000103}

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Shared Reference Notes

  • [1.1
    - Oral Klebsiella can colonize the gut and result in severe gut inflammation in susceptible individuals, thereby exacerbating inflammatory disease
  • [1.2] [#Premature infant
    - Klebsiella overgrowth in the gut is highly predictive for brain damage in permature infants and is associated with a pro-inflammatory immunological tone.
  • [1.3] [#Parkinson’s Disease] [#Lipopolysaccharide
    - of the 29 species that are reduced in PD, only 1 is a canonical Gram-negative organism, #Prevotella copri, which interestingly, produces an LPS that not only does not induce inflammation, but can inhibit TLR4 activation by others. - Eleven of the 55 species that are enriched in PD are canonical Gram-negative organisms including those with highly stimulatory LPS (#Escherichia coli, Klebsiella species, and #Porphyromonas asaccharolytica).
  • [1.4
    - The aggregated relative abundance of Klebsiella species was significantly higher in patients with #Crohn’s disease and #Primary sclerosing cholangitis when compared with healthy controls. - Several genes increased in the faecal microbiomes of patients with inflammatory bowel diseases > include hemolysin-coregulated protein and enzymes involved in fructose-, galactitol-, mannose-, and long-chain fatty acid-related uptake and metabolic pathways- were enriched in most faecal samples of the patients with inflammatory disease who carried Klebsiella species.

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