Microbiome & Chronic Diseases

Evidence Based Medicine
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Disease ⇒ Acne {40000267}

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Shared Reference Notes

  • [1.1] [#Cutibacterium acnes, #Staphylococcus epidermidis
    - Acne > increased #Actinobacteria followed by #Firmicutes and #Proteobacteria, #Cutibacterium,#Staphylococcus and #Corynebacterium. - C. acnes > major species in terms of mean abundance, followed by #Staphylococcus epidermidis (S. epidermidis) and #Staphylococcus hominis (S. hominis);
  • [1.2
    - An acneic #Cutibacterium acnes strain as well as its porphyrins activate NRLP3 inflammasome assembly, while this was not observed with a non-acneic strain.
  • [1.3] [#Gender
    - The men > a lower abundance of 18 microbes such as Butyricicoccus, Clostridium sensu stricto, Faecalibaculum, Bacillus, Lactococcus, Blautia, Clostridiales, Lachnospiracea incertae sedis, Ruminococcus at genus level > disordered metabolism of fatty acids. - The female patients > increased Clostridium sensu stricto and declined Oscillibacter and Odoribacterin > dysbiosis of amino acids metabolism
  • [1.4
    - #Lactobacilli can reduce acne lesions after daily application on the skin
  • [1.5
  • [1.6] [#Omega 3
    - After 10 weeks of omega-3 fatty acid or γ-#Linoleic acid supplementation, inflammatory and non-inflammatory acne lesions decreased significantly.
  • [1.7
    - the taxa #Enhydrobacter and #Stenotrophomonas were positively associated with transepidermal water loss (TEWL), stratum corneum hydration, respectively.
  • [1.8] [#Psoriasis
  • [1.9] [#Antibiotic Therapy
    - oral antibiotics for acne are a risk factor for new onset #Crohn’s disease
  • [#Cutibacterium acnes] [#Antibiotic Therapy] - a strain of #Staphylococcus capitis (S. capitis E12) that selectively inhibited growth of C. acnes with potency greater than antibiotics commonly used in the treatment of acne.
  • [1.11
    - increased β-diversity of the microbiome coincides with a successful treatment response to #Isotretinoin at 20 weeks.
  • [1.12
    - #Linoleic acid, a fatty acid required for acylceramide synthesis and essential for corneocyte lipid envelope formation. - This fatty acid is decreased in the epidermis in patients with ichthyosis, and acne-prone patients have low concentrations of #Linoleic acid and a relative lack of ceramide.
  • [1.13] [#Reactive Oxygen Species
    - #Propionibacteriaceae are Gram-positive, anaerobic rods associated with human infections, including corneal infections, and are often found in acne vulgaris patients. - Intradermal infections of #Propionibacteriaceae generate ROS and #Nitric Oxide and induce the synthesis of pro-inflammatory cytokines. Since an imbalance of these ROS and antioxidative tear proteins favors the development of tear film instability

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