Microbiome & Chronic Diseases

Evidence Based Medicine
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Streptococcus ⇒ Lactobacilli {10000318}

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Shared Reference Notes

  • [1.1
    - Some Lactobacilli > produce SCFAs > induce Tregs to modulate gut immune responses > shape the pulmonary immune environment > influence the severity of allergic inflammation.
  • [1.2] [#Iron-deficiency anaemia] [#Iron (ferric)
    - #Consumption of Fe supplements increases > Fe in the large intestine > reducing the amount of lactic acid bacteria (bifidobacteria and lactobacilli) and increasing the entropathogenic Escherichia coli
  • [1.3] [#Exercise training
    - Exercise increases > increase α-diversity and microbial metabolites such as SCFAs. - Exercise > typically reveal increases in commensal taxa such as #Bifidobacterium, Lactobacilli, and #Akkermansia
  • [1.4
    - Lactobacilli can reduce #Acne lesions after daily application on the skin
  • [1.5] [#Chronic Obstructive Pulmonary Disease
    - In Neutrophil-predominant COPD altered #Tryptophan metabolism in airway lactobacilli is associated with reduced #Indole-3-acetic acid (IAA), which was in turn linked to perturbed host interleukin-22 signalling and epithelial cell apoptosis pathways. - airway microbiome-derived IAA mitigates neutrophilic inflammation, apoptosis, emphysema and lung function decline, via macrophage–epithelial cell cross-talk mediated by interleukin-22. - Intranasal inoculation of two airway lactobacilli restored IAA and recapitulated its protective effects in mice.
  • [1.6
    - #Anthocyanins promote an increase in beneficial bacteria, including Lactobacilli and #Bifidobacteria, while reducing pathogenic bacteria, including Staphylococcus aureus and Salmonella typhimurium.
  • [1.7
    - #GABA is biosynthesized from #Glutamate due to the action of the enzyme #Glutamate decarboxylase, which is found in eukaryotic cells and in a broad spectrum of bacterial species. - LAB and more specifically certain Lactobacilli strains are the most important #GABA producers in the gut.
  • [1.8] [#Candida albicans
    - strains of #Bacteroides thetaiotaomicron and lactobacilli, have been shown to reduce C. albicans colonization of the gut
  • [#Candida albicans] - Lactobacilli can produce bacteriocins and hydrogen peroxide, which all contribute to a direct antifungal effect of lactobacilli. - by competing for adhesion sites, lactobacilli reduce adhesion of C. albicans to epithelial surfaces.
  • [1.9] [#Ruminococcus] [#Soybean
    - diet containing soy protein resulted in increased abundance of Enterococus and decreased abundance of Lactobacilli and Ruminococus in rats
  • -RiPPs from lactobacilli have shown to inhibit members of #Staphylococci, #Cutibacterium and #Corynebacterium
  • [#Short peptide bacteriocins] - #Lactocillin, a thiopeptide SPB isolated from a vaginal commensal #Lactobacillus was shown to inhibit several pathogens colonising skin or vagina and showed no antimicrobial activity against other lactobacilli species
  • [1.11] [#Alzheimer’s disease] [#Olive
    - Lactobacilli and #Bifidobacterium are often greatly reduced in patients with AD. - Both of these bacterial types, populations of which are elevated with EVOO consumption, can produce γ-aminobutyric acid (#GABA), the main inhibitory neurotransmitter, likely influencing GABAergic firing in the brain via the enteric and vagal nervous systems.

References Notes

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Common References