Microbiome & Chronic Diseases

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Prevotellaceae ⇒ Prevotella {10000253}

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- Prevotella contains enzymes that are important in mucin degradation, which may disrupt the colonic mucus barrier and increase intestinal permeability

Shared Reference Notes

  • [1.1
    - There is a correlation between higher gut microbiota diversity and higher vegetable intake, but only in participants who harbored an overrepresentation of Prevotella in their gut microbiota
  • [1.2] [#Sjögren syndrome
    -At the genera level, gut dysbiosis showed an increase in the abundance of the mucin-degrading and enteric pathogens Prevotella, Clostridium, Enterobacter, Escherichia, and Streptococcus and a depletion in the relative abundance of Bacteroides, Parabacteroides, Faecalibacterium, Roseburia, Ruminococcus, Dorea, Alistipes, Blautia and Bifidobacterium. - Prevotella contains enzymes that are important in mucin degradation, which may disrupt the colonic mucus barrier and increase intestinal permeability allowing the diffusion of pathogens, toxins, and antigens from the luminal environment into the mucosal tissues and circulatory system, resulting in the immune activation and tissue inflammation important in the onset or progression of several intestinal and chronic autoimmune diseases.
  • [1.3] [#Antibiotic Therapy
    - Recent exposure to antibiotics is the best predictor of decreased Prevotella.
  • [#Infants] - There is a clear association between decreased normalised abundance of Prevotella in faecal samples collected at 12 months of age and increased behavioural problems at 2 years.
  • [1.4] [#Polycystic ovary syndrome
    - #Lactobacillus given to letrozole-treated (induces PCOS) rats reduced androgen levels, improved estrous cyclicity, normalized ovarian morphology, as well as increased #Lactobacillus and #Clostridium species and decreased Prevotella.
  • [1.5] [#High-fiber diet
    - Carbohydrate (fiber) consumption > increased Prevotella
  • [#Mediterranean diet] - Prevotella are more common in non-Westernized populations consuming a plant-rich diet or in Western populations with high adherence to a Mediterranean or vegetarian diet
  • [1.6] [#Carbohydrate diet
    - Prevotella grows best on carbohydrates.
  • [1.7] [#Rheumatoid Arthritis
    - Prevotella in saliva is at higher relative abundance compared to healthy controls.
  • [1.8] [#Parkinson’s Disease
    - Decreased Prevotella > faster PD progression
  • [1.9] [#Hypertension
    - 9,10-dichloro-octadecanoic acid (stearic acid) > positive association > microflora including Klebsiella, Prevotella, and Enterbacter > all overrepresented in HTN. - In HTN > microbial richness and diversity > decreased with Prevotella-dominated gut enterotype. - Faecalibacterium, Oscillibacter, Roseburia, Bifidobacterium, Coprococcus, and Butyrivibrio > declined in pHTN and HTN patients. - The enterotype dominated by Prevotella > increased in pHTN and HTN populations. - Stearic acid, an important metabolite in HTN, is positively linked to Prevotella. - Prevotella > triggering the inflammatory response > HTN.
  • [#Parkinson’s Disease] [#Bifidobacterium adolescentis] - PD patients, showing an increase in #Akkermansia, Bifidobacterium, and #Lactobacillus and a decrease in Prevotella
  • [1.11] [#Psychogenic erectile dysfunction
    - Erectile dysfunction > no #Alloprevotella . - Erectile dysfunction > increased #Streptococci and #Subdoligranulum - Erectile dysfunction > decreased Prevotella sp.9, #Blautia, #Lachnospiraceae NK4A136 groups and #Roseburia.
  • [1.12] [#Carbohydrate diet, #High protein / animal fat diets
    - high protein animal fat diets are associated with #Bacteroides, whereas diets high in carbohydrates are associated with a high prevalence of Prevotella
  • [1.13] [#Multidrug-Resistant Organism
    - abundance of Bacillales Family XI incertae sedis and Prevotella families were associated with lower risk of colonization by MDRO, infection and death
  • [1.14] [#Infectious diarrhea
    - A drastic disappearance of obligate anaerobic gut commensals (#Blautia, Prevotella, #Faecalibacterium, #Lachnospiraceae, #Ruminococcaceae, etc.), leading to a depletion of associated metabolites such as #Short Chain Fatty Acid (SCFAs)
  • [1.15] [#Resistant starch
    - RS consumption was associated with an increased abundance of either #Bacteroides or Prevotella transcripts.
  • [1.16] [#Amyotrophic lateral sclerosis
    - The gut microbial communities of the ALS patients were more diverse and were deficient in Prevotella spp. compared with those of their spouses. - Predictive analysis of microbial enzymes revealed that ALS patients had decreased activity in several metabolic pathways, including carbon metabolism, #Butyrate metabolism, and systems involving histidine kinase and response regulators.
  • [1.17] [#Parkinson’s Disease
    - Certain bacterial species of the genus #Corynebacterium, #Porphyromonas, and Prevotella have been noted to be significantly abundant in PD and associated with #SCNA genes. - An overabundance of the unusually low #Corynebacterium and endotoxins of the #Porphyromonas and Prevotella can trigger the PD pathology in the gut.
  • [1.18] [#Gallstone Disease
    - that abundance of Prevotella spp. may play a protective role against gallstones formation by regulation of the BAs composition, reducing metabolic endotoxaemia and protection of the mucosal gut barrier.
  • - Mucosal inflammation mediated by Prevotella spp. could promote systemic dissemination of various pro-inflammatory mediators, as well as bacteria and bacterial products, which in turn may trigger systemic diseases.
  • [1.19] [#Obesity] [#Whole grains
    - Harboring high levels of Prevotella at baseline resulted in increased weight loss in individuals with excess body weight who consumed whole grain-rich diets
  • [#Parkinson’s Disease] - lower fecal #Butyrate and reduced counts of genera #Roseburia, #Romboutsia, and Prevotella are related to depressive symptoms in PD patients. - Decreased levels of bacterially produced #Butyrate are related to epigenetic changes in leucocytes and neurons from PD patients and to the severity of their depressive symptoms.
  • [1.21] [#Covid-19
    -anti-inflammatory bacteria, including #Bifidobacteria species and #Eubacterium rectale, with lower severity, and pro-inflammatory bacteria such as Prevotella copri with higher severity.
  • [1.22] [#Irritable bowel syndrome
    - symptom severity is related to characteristic alterations of gut microbiota, including reduced diversity, reduced exhaled methane, relative reduction of #Methanobacteriales and Prevotella enterotype, and abundance of #Bacteroides enterotype. - #Bacteroides were found to be increased in patients with IBS-D and were associated with mucosal low-grade inflammation.
  • [1.23] [#Carbohydrate diet
    - carbohydrate-rich diet was consumed Prevotella-dominated enterotype
  • [1.24] [#Autism
    - lower levels of Prevotella and #Bifidobacterium may lead to reduced levels of #Folate production due to diminished #Folate-dependent remethylation in ASD
  • [#Autism] - lower or depleted levels of Prevotella in ASD compared to TD in fecal and oral microbiota. - Many gut Prevotella species are fiber-consuming bacteria.
  • [1.25] [#Parkinson’s Disease
    - #Firmicutes enrichment as the primary driving force, and depletion of Prevotella as secondary as it remained significant after removing #Firmicutes.
  • [#Parkinson’s Disease] [#Prevotella copri] - Prevotella has been reported as decreased in PD by some and increased by others. - Prevotella copri was decreased, and the pathogenic species of Prevotella were increased as a group, confirming, and resolving the seemingly contradictory reports on Prevotella.
  • [1.26
    - At the genus level, Prevotella and #Bacteroides were significantly enriched in the #Meditation group. - Two beneficial bacterial genera (#Megamonas and #Faecalibacterium) were significantly enriched in the #Meditation group. - Several pathways—including glycan biosynthesis, metabolism and lipopolysaccharide biosynthesis—were significantly enriched in the #Meditation group. - Plasma levels of clinical risk factors were significantly decreased in the #Meditation group, including total #Cholesterol and apolipoprotein B.
  • [1.27] [#Bipolar disorder
    - Prevotella 2 and #Ruminococcaceae UCG-002 are more prevalent in patients with MDD than BD patients. - MDD is associated with alterations in #Bacteroidaceae family, whereas disturbances in #Lachnospiraceae, #Prevotellaceae, and #Ruminococcaceae families are related to BD
  • [1.28] [#Alzheimer’s disease
    - AD Mouse > an increase in #Odoribacter and #Helicobacter genera and decreases in Prevotella species.
  • [1.29] [#Oleic acid, #Stearic acid
    - mice with severe #Psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms > increased the abundance of Prevotella, while decreasing that of #Parabacteroides distasonis, in the colon > increasing the abundance of oleic and stearic acids.
  • - #Gentamicin treatment significantly reduced the abundance of Prevotella and alleviated the #Psoriasis-like symptoms in both K14-VEGF mice and imiquimod (IMQ)-induced #Psoriasis-like mice.
  • [#Diabetes Type 2] - The genus #Blautia was one of the most represented genera in both groups enriched in group T2D. - #Lachnoclostridium were more abundant in the microbiome profiles of diabetic patients. - There are anomalies in the genera #Bacteroides and Prevotella, both of which are increased in the T2D, both genera are #Propionate producers.

References Notes

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