Prevotellaceae ⇒ Prevotella {10000253} Record Keys Parent:Prevotellaceae Definition:Prevotella Details Initialisation date:2020-09-29 Meta Information Rank: Genus Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:Mucin-degrading Notes: - Prevotella contains enzymes that are important in mucin degradation, which may disrupt the colonic mucus barrier and increase intestinal permeabilityShared Reference Notes [1.1] - There is a correlation between higher gut microbiota diversity and higher vegetable intake, but only in participants who harbored an overrepresentation of Prevotella in their gut microbiota [1.2] [#Sjögren syndrome ] -At the genera level, gut dysbiosis showed an increase in the abundance of the mucin-degrading and enteric pathogens Prevotella, Clostridium, Enterobacter, Escherichia, and Streptococcus and a depletion in the relative abundance of Bacteroides, Parabacteroides, Faecalibacterium, Roseburia, Ruminococcus, Dorea, Alistipes, Blautia and Bifidobacterium. - Prevotella contains enzymes that are important in mucin degradation, which may disrupt the colonic mucus barrier and increase intestinal permeability allowing the diffusion of pathogens, toxins, and antigens from the luminal environment into the mucosal tissues and circulatory system, resulting in the immune activation and tissue inflammation important in the onset or progression of several intestinal and chronic autoimmune diseases. [1.3] [#Hypertension] - Elevated putative #Succinate-producing bacteria and #Acetate-producing bacteria > respectively, lower and higher mean arterial pressure in mouse - Prevotella and #Klebsiella > overrepresented in individuals with pHTN or HTN. [1.4] [#Antibiotic Therapy] - Recent exposure to antibiotics is the best predictor of decreased Prevotella. [#Infants] - There is a clear association between decreased normalised abundance of Prevotella in faecal samples collected at 12 months of age and increased behavioural problems at 2 years. [1.5] [#Polycystic ovary syndrome] - #Lactobacillus given to letrozole-treated (induces PCOS) rats reduced androgen levels, improved estrous cyclicity, normalized ovarian morphology, as well as increased #Lactobacillus and #Clostridium species and decreased Prevotella. [1.6] [#High fibre diet] - Carbohydrate (fiber) consumption > increased Prevotella [#Mediterranean diet] - Prevotella are more common in non-Westernized populations consuming a plant-rich diet or in Western populations with high adherence to a Mediterranean or vegetarian diet [1.7] [#Carbohydrate diet] - Prevotella grows best on carbohydrates. [1.8] [#Rheumatoid Arthritis] - Prevotella in saliva is at higher relative abundance compared to healthy controls. [1.9] [#Parkinson’s Disease] - Decreased Prevotella > faster PD progression [#Hypertension] - 9,10-dichloro-octadecanoic acid (stearic acid) > positive association > microflora including Klebsiella, Prevotella, and Enterbacter > all overrepresented in HTN. - In HTN > microbial richness and diversity > decreased with Prevotella-dominated gut enterotype. - Faecalibacterium, Oscillibacter, Roseburia, Bifidobacterium, Coprococcus, and Butyrivibrio > declined in pHTN and HTN patients. - The enterotype dominated by Prevotella > increased in pHTN and HTN populations. - Stearic acid, an important metabolite in HTN, is positively linked to Prevotella. - Prevotella > triggering the inflammatory response > HTN. [1.11] [#Parkinson’s Disease] [#Bifidobacterium adolescentis] - PD patients, showing an increase in #Akkermansia, Bifidobacterium, and #Lactobacillus and a decrease in Prevotella [1.12] [#Psychogenic erectile dysfunction] - Erectile dysfunction > no #Alloprevotella . - Erectile dysfunction > increased #Streptococci and #Subdoligranulum - Erectile dysfunction > decreased Prevotella sp.9, #Blautia, #Lachnospiraceae NK4A136 groups and #Roseburia. [1.13] [#Carbohydrate diet, #High protein / animal fat diets] - high protein animal fat diets are associated with #Bacteroides, whereas diets high in carbohydrates are associated with a high prevalence of Prevotella [1.14] [#Multidrug-Resistant Organism] - abundance of Bacillales Family XI incertae sedis and Prevotella families were associated with lower risk of colonization by MDRO, infection and death [1.15] [#Infectious diarrhea] - A drastic disappearance of obligate anaerobic gut commensals (#Blautia, Prevotella, #Faecalibacterium, #Lachnospiraceae, #Ruminococcaceae, etc.), leading to a depletion of associated metabolites such as #Short Chain Fatty Acid (SCFAs) [1.16] [#Resistant starch] - RS consumption was associated with an increased abundance of either #Bacteroides or Prevotella transcripts. [1.17] [#Amyotrophic lateral sclerosis] - The gut microbial communities of the ALS patients were more diverse and were deficient in Prevotella spp. compared with those of their spouses. - Predictive analysis of microbial enzymes revealed that ALS patients had decreased activity in several metabolic pathways, including carbon metabolism, #Butyrate metabolism, and systems involving histidine kinase and response regulators. [1.18] [#Parkinson’s Disease] - Certain bacterial species of the genus #Corynebacterium, #Porphyromonas, and Prevotella have been noted to be significantly abundant in PD and associated with #SCNA genes. - An overabundance of the unusually low #Corynebacterium and endotoxins of the #Porphyromonas and Prevotella can trigger the PD pathology in the gut. [1.19] [#Gallstone Disease] - that abundance of Prevotella spp. may play a protective role against gallstones formation by regulation of the BAs composition, reducing metabolic endotoxaemia and protection of the mucosal gut barrier. - Mucosal inflammation mediated by Prevotella spp. could promote systemic dissemination of various pro-inflammatory mediators, as well as bacteria and bacterial products, which in turn may trigger systemic diseases. [#Obesity] [#Whole grains] - Harboring high levels of Prevotella at baseline resulted in increased weight loss in individuals with excess body weight who consumed whole grain-rich diets [1.21] [#Parkinson’s Disease] - lower fecal #Butyrate and reduced counts of genera #Roseburia, #Romboutsia, and Prevotella are related to depressive symptoms in PD patients. - Decreased levels of bacterially produced #Butyrate are related to epigenetic changes in leucocytes and neurons from PD patients and to the severity of their depressive symptoms. [1.22] [#Covid-19] -anti-inflammatory bacteria, including #Bifidobacteria species and #Eubacterium rectale, with lower severity, and pro-inflammatory bacteria such as Prevotella copri with higher severity. [1.23] [#Irritable bowel syndrome] - symptom severity is related to characteristic alterations of gut microbiota, including reduced diversity, reduced exhaled methane, relative reduction of #Methanobacteriales and Prevotella enterotype, and abundance of #Bacteroides enterotype. - #Bacteroides were found to be increased in patients with IBS-D and were associated with mucosal low-grade inflammation. [1.24] [#Carbohydrate diet] - carbohydrate-rich diet was consumed Prevotella-dominated enterotype [1.25] [#Autism] - lower levels of Prevotella and #Bifidobacterium may lead to reduced levels of #Folate production due to diminished #Folate-dependent remethylation in ASD [#Autism] - lower or depleted levels of Prevotella in ASD compared to TD in fecal and oral microbiota. - Many gut Prevotella species are fiber-consuming bacteria. [1.26] [#Parkinson’s Disease] - #Firmicutes enrichment as the primary driving force, and depletion of Prevotella as secondary as it remained significant after removing #Firmicutes. [#Parkinson’s Disease] [#Prevotella copri] - Prevotella has been reported as decreased in PD by some and increased by others. - Prevotella copri was decreased, and the pathogenic species of Prevotella were increased as a group, confirming, and resolving the seemingly contradictory reports on Prevotella. [1.27] - At the genus level, Prevotella and #Bacteroides were significantly enriched in the #Meditation group. - Two beneficial bacterial genera (#Megamonas and #Faecalibacterium) were significantly enriched in the #Meditation group. - Several pathways—including glycan biosynthesis, metabolism and lipopolysaccharide biosynthesis—were significantly enriched in the #Meditation group. - Plasma levels of clinical risk factors were significantly decreased in the #Meditation group, including total #Cholesterol and apolipoprotein B. [1.28] [#Alzheimer’s disease] - AD Mouse > an increase in #Odoribacter and #Helicobacter genera and decreases in Prevotella species. [1.29] [#Oleic acid, #Stearic acid] - mice with severe #Psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms > increased the abundance of Prevotella, while decreasing that of #Parabacteroides distasonis, in the colon > increasing the abundance of oleic and stearic acids. - #Gentamicin treatment significantly reduced the abundance of Prevotella and alleviated the #Psoriasis-like symptoms in both K14-VEGF mice and imiquimod (IMQ)-induced #Psoriasis-like mice. [#Diabetes Type 2] - The genus #Blautia was one of the most represented genera in both groups enriched in group T2D. - #Lachnoclostridium were more abundant in the microbiome profiles of diabetic patients. - There are anomalies in the genera #Bacteroides and Prevotella, both of which are increased in the T2D, both genera are #Propionate producers. [1.31] [#Bipolar disorder, #Major depressive disorder, #Schizophrenia] - MDD was often characterized by higher #Alistipes and #Parabacteroides and lower Prevotella; BD by higher #Bifidobacterium and #Oscillibacter; and SZ by higher Prevotella and lower #Bacteroides, #Haemophilus, and #Streptococcus [#Bipolar disorder, #Major depressive disorder] - Prevotella 2 and #Ruminococcaceae UCG-002 are more prevalent in patients with MDD than BD patients. [#Bipolar disorder] - Levels of #Faecalibacterium prausnitzii, #Bacteroides–Prevotella group, #Atopobium Cluster, #Enterobacter spp. and #Clostridium cluster IV were higher in BD patients than healthy subjects along with a reduced #Bifidobacteria to #Enterobacteriaceae ratio, having these changes a possible impact on brain function in these patients. [1.32] [#High-protein diet] - Excessive protein intake > causing the growth of protein fermenting bacteria as #Clostridium, #Desulfovibrio, #Peptostreptococcus, #Acidaminococcus, #Veillonella, #Propionibacterium, Bacillus, #Bacteroides, #Staphylococcus, and other species of the #Proteobacteria family, and the loss of carbohydrate fermenting bacteria such as #Bacteroides, #Lactobacillus, #Bifidobacterium, Prevotella, #Ruminococcus, #Roseburia, and #Faecalibacterium. - Excesive #Sport > Prevotella is increased, due to its high BCAA metabolism capacity (lysine biosynthesis), as well as the participation in the metabolism of #Alanine, aspartate, and #Glutamate, #Glutamine, beyond carbohydrate. [1.33] [#Inflamatory bowel disease, #Ulcerative Colitis] - In terms of IBD, Prevotella is a potential alternative biomarker for UC, tightly matched with feces and other oral areas - Prevotella owns a unique nitrogen assimilation metabolic network that rarely limits their growth. - Binding or attaching to other bacteria and epithelium, Pretovella creates a larger infection than in previously infected areas. [#Animal fat consumption, #High protein / animal fat diets, #Western-style diet] - high animal protein and saturated fat diet western people own higher diversity of inflammation-associated Prevotella in the oral cavity, [#Prevotella amnii, #Prevotella corporis, #Prevotella denticola, #Prevotella disiens, #Prevotella marshii] - Prevotella predominates in the intestinal microbiome in the preclinical phase of #Rheumatoid Arthritis, promoting pathological progression in a TH17 cell-dependent manner. - gut microbiome from #Rheumatoid Arthritis patients > five species that belong to the Prevotella (i.e., P. denticola, P. marshii, P. disiens, P. corporis, and P. amnii) [1.34] [#Obesity] [#Physical activity] - In normal but not overweight participants, high PA duration showed greater relative abundance of commensal taxa such as #Actinobacteria and #Proteobacteria phyla, as well as #Collinsella and Prevotella genera. [1.35] - Higher proportions of #Bacteroidetes, namely Prevotella, and lower proportions of #Firmicutes (#Streptococcus, #Veillonella, #Gemella, and #Lactobacillaceae) are found in the duodenum compared with the jejunum. [1.36] [#Gastric carcinoma] - The oral taxa #Neisseria, Prevotella, and #Veillonella had centralities in tumors with intestinal and mixed phenotypes and were associated with MUC13 overexpression, highlighting their role as potential drivers in MUC13 signaling in GC. [1.37] [#Animal fat consumption, #Beef protein high-fat diets (HFB), #High protein / animal fat diets, #High satureted fat diet] - The first enterotype, high in #Bacteroides and low in Prevotella, is found in individuals on a long-term Western diet high in animal protein, the nutrient #Choline, and saturated fat. - The second enterotype is high in Prevotella, low in #Bacteroides, and associated with a #Plant-based diet rich in fiber, simple sugars, and plant-derived compounds. [1.38] -The genera #Neisseria, Prevotella and #Haemophilus are also highly abundant, with a prevalence of 6–29%, depending on the site. [1.39] [#Acute lymphoblastic leukemia] - #Roseburia, #Dialister, Prevotella, #Faecalibacterium and #Anaerostipes showed reduced relative abundance in #Children with ALL at the time of diagnosis - delayed maturation of the gut microbiome (characterized by reduced relative abundance of the genera #Roseburia, #Dialister, Prevotella, #Faecalibacterium and #Blautia and increased abundance of #Enterococcus), as well as reduced stool levels of #Butyrate by the age of 12 months, is associated with aberrant immune responses and an increased risk of #Asthma diagnosis by the age of 5 years [#Children] - delayed entry into #Daycare is associated with reduced relative abundance of #Lachnospiraceae, #Ruminococcaceae and Prevotella spp. and delayed maturation of the gut microbiome. [#Short Chain Fatty Acid] - School-age #Children living in #Urban areas show reduced relative abundance of bacteria (for example, Prevotella spp.) capable of fermenting complex carbohydrates for the production of SCFAs and reduced stool levels of all major SCFAs. [#Carbohydrate diet, #Sugar] - carbohydrate-rich diets, including dietary fiber and simple sugars, belong to the Prevotella enterotype. [1.41] [#Bile Acids] - The majority of the #Bacteroidetes species fall into three genera: Prevotella (bile-sensitive, moderately saccharolytic, with pigmented and nonpigmented species), #Porphyromonas (bile-sensitive, pigmented, asaccharolytic species), and #Bacteroides (bile-resistant, nonpigmented, saccharolytic species). - Some members of the genera #Porphyromonas, Prevotella, and #Tannerella are well-known pathogens of the oral cavity, where they can notably cause #Periodontal disease and dental #Caries. - In healthy human stomach, the genera #Streptococcus, Prevotella, #Veillonella, #Rothia, and #Haemophilus were found to be predominant. [1.42] [#Candida albicans, #Streptococcus mutans] - The presence of C. albicans would increase the abundance of #Streptococcus (particularly S. mutans), certain #Lactobacillus species, and salivary #Veillonella and Prevotella, and also increase the cariogenic virulence of biofilms [1.43] [#Clostridium cluster XVIII, #Clostridium clusters XIVa] - #Aspirin > differentially abundant > Prevotella, #Veillonella, Clostridium XIVa and Clostridium XVIII clusters [1.44] [#Autism] - Prevotella, #Bacteroides and #Bifidobacterium were predominantly associated with the cytokine differentials. [#Fecal Microbiota Transplantation] - children were subjected to a 2-week antibiotic treatment and a bowel cleanse, followed by 2 d of high-dose FMT treatment and 8 weeks of daily maintenance FMT doses. - based on the Childhood #Autism Rating Scale (CARS), significant improvements were achieved after the 10-week course of treatment. - Two months later, the initial gains were largely maintained, and a 2-year follow-up showed signs of further improvement in most of the patients. - increase in Prevotella sp. over the 2-year span of the study. - increase in #Desulfovibrio piger [1.45] - The human gut microbiome has been sorted into five “enterosignatures.” - These are dominated by #Bacteroides, #Firmicutes, Prevotella, #Bifidobacterium, or #Escherichia. [1.46] [#Clostridium cluster IV] - TNF-α was found to be positively correlated with the abundance of #Parabacteroides, #Bilophila, and #Clostridium IV, but negatively correlated with the abundance of Prevotella. [#Bipolar disorder] - #Serum CRP concentration was positively correlated with Prevotella abundance, but negatively correlated with #Butyricicoccus, #Lachnospiraceae incertae sedis and #Dorea abundance in BD patients. [#Bipolar disorder] - in BD patients. Acute stress could reduce Prevotella abundance and result in an inflammatory response [#Serum CRP, #Serum triglycerides] - The abundance of Prevotella was positively associated with serum levels of triglycerides (TG) and high-sensitive CRP (hs-CRP) [1.47] [#Vitamin B12] - The smallintestine a lso contains microbes, such as #Bacteroides and Prevotella, that aid in the synthesis of micronutrients, like #Vitamin K2 and B12 [1.48] - #Leptin serum level was positively correlated with the abundance of #Bifidobacterium and ##Lactobacillus whereas #Leptin serum level was negatively correlated with #Clostridium, #Bacteroides and, Prevotella [1.49] [#High protein / animal fat diets, #High fibre diet] - fiber rich diets associate with a higher abundance of Prevotella spp., whereas a protein and fat rich diet (low fiber) enriches #Bacteroides spp. - The #Bacteroidetes phylum mainly consists of #Bacteroides and Prevotella. [1.51] [#Hepatocellular cancer] - hepatocellular carcinoma > Prevotella was enriched in patients with Progressive Disease. - hepatocellular carcinoma > #Lachnoclostridium, #Lachnospiraceae, and #Veillonella were predominant in patients with objective responses. [#Hepatocellular cancer] - hepatocellular carcinoma > The coexistence of #Lachnoclostridium enrichment and Prevotella 9 depletion significantly predicted better overall survival (OS) [1.52] - Celiac > microbiota is abundant with pro-inflammatory Gram-negative species, such as #Proteobacteria, Bacterioides, Prevotella, ecc., while it is poor in probiotic ones, such as #Firmicutes, #Actinobacteria, #Bifidobacteria, #Lactobacilli, and Streptococceae, which have instead a protective rol [1.53] [#Animal-based diet, #Animal fat consumption] - animal-based diets (typically called a “Western” diet with high amounts of animal fat and protein, and processed carbohydrates) induce decreased levels of beneficial species within the #Firmicutes phyla and strains from the genus Prevotella; while levels of bile-tolerant, inflammation-associated #Proteobacteria, such as #Bilophila, and #Bacteroides are increased [#Plant-based diet] - plant-rich diets are associated with greater microbial diversity with a dominance of Prevotella over #Bacteroides. [#High fibre diet, #Plant-based diet] - The genus Prevotella is expanded with complex carbohydrate intake as these microbes contain specific enzymes that are capable of degrading plant fibres [1.54] [#Hepatocellular cancer] [#Short Chain Fatty Acid] - Probiotics also increase bacteria that produce SCFA, such as #Butyricimonas and Prevotella, and prevent HBV and HCV infections, thereby reducing HCC progression [1.55] - Enhanced #Pantothenic acid intake increased the relative abundance of Prevotella and #Actinobacteria and decreased the abundance of #Bacteroides in lactating women - #Vitamin B12 supplementation in humans increased the relative abundance of Prevotella, but decreased the abundance of #Bacteroides - Prevotella and #Desulfovibrio, is overexpressed with four enzymes—hydroxymethylpyridine kinase, phosphomethylpyridine kinase, thiamine-phosphate pyrophosphorylase, and thiamine-monophosphate kinase—crucial for #Thiamin biosynthesis - #Riboflavin supplementation increased the abundance of bacteria that cannot synthesize #Riboflavin, such as #Faecalibacterium prausnitzii and #Roseburia spp. - Higher intake was also associated with an increase in the abundance of Prevotella spp. [#Lachnospiraceae] - An abundance of Lachnospiraceae_NK4A136_group and Prevotella were elevated with #Vitamin B6 deficiency, [1.56] [#Oral squamous cell carcinoma] - specific bacteria have been identified that correlate strongly with Oral squamous cell carcinomas (OSCCs), such as #Streptococcus sp., #Peptostreptococcus sp., Prevotella sp., #Porphyromonas gingivalis, and #Capnocytophaga gingivalis [#Oral squamous cell carcinoma] - most often observed oral bacteria in OSCCs are #Streptococcus sp., #Peptostreptococcus sp., Prevotella sp., #Porphyromonas gingivalis, and #Capnocytophaga gingivalis [1.57] [#Ulcerative Colitis] [#Short Chain Fatty Acid] - UC > depletion of SCFA-producing #Bacteria such as Prevotella, #Roseburia, #Lachnospiraceae, and #Ruminococcaceae. [#Ulcerative Colitis] - Prevotella_7 and #Blautia taxa abundance, as well as two metabolic pathways, might serve as a discriminating signature between north Indian UC patients with active disease and those in remission. [1.58] [#Tuberculosis] - Prevotella, which is better equipped to consume plant-derived carbohydrates, was markedly depleted in TB patients, while the abundance of #Bacteroides was increased [#Tuberculosis] - Prevotella and #Bifidobacterium were markedly reduced in TB patients. [1.59] [#Ankylosing spondylitis] [#Prevotella copri, #Prevotella melaninogenica] - patients with AS and healthy controls, multiple Prevotella species were relatively more abundant in the patient cohort. Among these, P. copri, P. melaninogenica, and Prevotella sp. C561. [#Prevotella copri] - Prevotella and P. copri-like operational taxonomic units were absent in children with #Autism suffering from gastrointestinal problems unrelated to their diet. - in another study, the relative abundance of P. copri was significantly higher in children with ASD than that in healthy controls. - enrichment of P. copri in patients with T2D and suggested P. copri as a potential biomarker. [#Prevotella copri] - #Wheat bran extract, enriched in #Arabinoxylan oligosaccharides, enhances the growth of Prevotella species, especially P. copri. [#High fibre plant protein-rich diet, #Plant Microbiome, #Plant-based diet] - Prevotella thrives on plant- or fiber-rich diets. - These include diets commonly described as non-Western, Mediterranean, or rural African diet. - Prevotella synthesizes #Sulfatase enzymes that degrade the intestinal mucosa’s mucin lining. - increase in the relative abundances of #Verrucomicrobiaceae and #Akkermansia and a decrease in #Prevotellaceae and Prevotella [#Parkinson’s Disease] - A previous study showed that #Constipation is lowest and subthreshold parkinsonism is least frequent in individuals with the Prevotella-enriched enterotype [#Parkinson’s Disease] - Prevotella, a highly specific prodromal marker of PD, has been associated with RBD and with progressive PD motor symptoms over 2 years [1.61] [#Multiple Sclerosis] - Individuals with relapsing-remitting MS have an abundance of #Mycoplasma, #Pseudomonas, #Faecalibacterium, #Haemophilus, #Anaerostipes, #Blautia, and #Dorea, while #Bacteroides, Prevotella, #Parabacteroides, and #Adlercreutzia are relatively less common. [1.62] [#Parkinson’s Disease] - #Lactobacillus and #Bifidobacterium genus were most abundant in PD patients. Prevotella VZCB and other #Faecalibacterium were most abundant in controls. [1.63] [#Carbohydrate diet] - On a #Fructose-rich diet, mice lost beneficial bacteria such as Prevotella, #Muribaculum, and #Bifidobacterium - These #Fructose-rich diet mice also showed an enrichment of #Desulfovibrio, #Collinsella, #Olsenella, and #Bacteroides as well as increased frequency of immune cells with pro-inflammatory characteristics [#Multiple Sclerosis] - Several gut bacteria lacking in MS such as Prevotella, #Parabacteroides, #Adlercreutzia, and #Bifidobacterium can metabolize dietary #Phytoestrogen. [1.64] [#Juvenile idiopathic arthritis] - ABIS JIA had higher abundance of #Acidaminococcales, Prevotella 9, and #Veillonella parvula and lower abundance of #Coprococcus, #Subdoligranulum, #Phascolarctobacterium, #Dialister spp., #Bifidobacterium breve, #Fusicatenibacter saccharivorans, #Roseburia intestinalis, and #Akkermansia muciniphila [#Juvenile idiopathic arthritis] [#Human breast milk] - taxa associated with ABIS JIA had a significant association with shorter durations of breastfeeding, including #Acidaminococcales, Prevotella 9, #Parabacteroides distasonis, and several ASVs belonging to #Bacteroides, #Veillonella parvula, #Turicibacter sanguinis, #Eggerthella lenta, and P. distasonis. [#Juvenile idiopathic arthritis] [#Antibiotic Therapy] - Prevotella 9 and #Acidaminococcales were higher in ABIS JIA, #Infants with antibiotic exposures, and #Infants who had #Siblings. [#Juvenile idiopathic arthritis] - increased Prevotella 9 prevalence was found in #Infants who later developed JIA compared to matched controls [#Rheumatoid Arthritis] [#Prevotella copri] - Prevotella 7 and Prevotella 9, the latter of which matched in identity to P. copri, have been associated with polygenic risk scores and genetic risk for RA. [1.65] [#Carbohydrate diet] - Long-term consumption of complex carbohydrates in humans can enrich Prevotella bacteria [1.66] - The respiratory microbiota primarily consists of bacteria such as Prevotella, #Veillonella, and #Streptococcus [1.67] - SUA levels and #Gout simultaneously affect the abundance of the genus #Faecalibacterium and Prevotella. - #Gout patients had lower levels of the genus #Faecalibacterium compared to healthy individuals. - negative association between SUA levels and #Faecalibacterium abundance. - SUA levels are a risk factor for the increased abundance of genus Prevotella9 [1.68] - Prevotella bacteria exhibit properties that increase inflammatory responses, possibly related to its ability to drive immune responses to Th17 cytokines [#Rheumatoid Arthritis] [#Ruminococcaceae] - #High humidity aggravated joint injury in CIA rats, which may be related to the high abundance of bacterial species such as Prevotella, #Clostridia, and Ruminococcaceae_UCG_010 induced by #High humidity, which could promote the immune response of Th17 cells. [#Rheumatoid Arthritis] - Prevotella, #Ruminococcaceae and #Clostridia were associated with RA because they induce the inflammatory response mediated by #IL-6, #IL-17 and IFN-γ cytokines [1.69] [#Alzheimer’s disease, #Amyotrophic lateral sclerosis, #Parkinson’s Disease] - the abundance of bacteria from the Prevotella genus negatively correlates with the pathogenicity and prevalence of different PCDs, including ALS, PD, and a mouse AD model > neuroprotective role of Prevotella spp. [#Parkinson’s Disease] - A decreased abundance of Prevotella spp. is also associated with #Constipation, a condition that precedes motor symptoms in PD patients by up to 20 years - there are 61 species of Prevotella, but only about 20 are associated with human diseases [#Clostridium difficile associated disease, #Clostridium difficile infection] - patients who are likely to develop R-CDI have higher levels of #Calprotectin, together with a higher abundance of #Fusobacterium and lower abundance of #Senegalimassilia, Prevotella and #Ruminococcus. [#Clostridium difficile associated disease] - #Fusobacterium increased in abundance, while #Collinsella, #Senegalimassilia, Prevotella and #Ruminococcus decreased in patients with recurrent versus non-recurrent disease. [1.71] [#Alzheimer’s disease] [#Atopobium rimae, #Bacteroides-Prevotella group, #Prevotella nigrescens, #Prevotella oulorum, #Treponema socranskii, #prevotella salivae] - subgingival samples of the AD group showed significant increases in the abundance of bacterial species potentially linked with periodontitis, such as A. rimae, #Saccharibacteria (#TM7) HMT 348, #Selenomonas sp. HMT 442, T. socranskii and various Prevotella spp., such as P. maculosa, P. multiformis, P. nigrescens, P. oulorum and P. salivae, which could aggravate systemic diseases. [#Alzheimer’s disease] - potential periodontal pathogens such as Prevotella, #Saccharibacteria (#TM7), #Treponema and #Selenomonas spp. were significantly more abundant in the AD group, especially in subgingival plaque. - Prevotella spp. were densely interconnected with various oral microbiome. [#Natural oral microbiomes] - Prevotella is a natural component of human microflora commonly found in the oral cavity and saliva [1.72] [#Helicobacter pylori] - reduced levels of #Nesterenkonia but increased levels of #Methylophilaceae, #Fusobacterium, Prevotella, #Actinomyces, #Novosphingobium, and H. pylori in #Extrahepatic Cholangiocarcinoma cases. [1.73] - the proportion of Prevotella in #Oral cancer tissue was larger than that in normal tissue [1.74] [#Butanoic acid, #Short Chain Fatty Acid] - SCFAs, particularly butanoic and #Acetic acid, can be produced by #Faecalibacterium, #Roseburia, #Sutterella, and Prevotella [1.75] [#Bladder cancer] - the #Howardella genus and the #Streptococcus anginosus strain were more common in women. - no differences in the diversity of urine between sexes; however, in the urine of women, there was a higher abundance of the genera #Lactobacillus, Actinotignum, Prevotella, #Veillonella, and #Campylobacter. [#Clostridium group XI] - reduced abundance of #Clostridium cluster XI and Prevotella in the gut microbiome of patients with #Bladder cancer. [1.76] - levels of Prevotella, #Dehalobacterium, #Ruminococcus, and #Lactobacillus were found to be remarkably lower in rat model of #Hyperuricemia. [1.77] [#Obesity] - individuals with the Prevotella-driven enterotype appeared more susceptible to lose body fat on fiber-rich diet [1.78] - The #Cranberry extract supplementation increased the abundance of #Faecalibacterium and #Agathobacter in subjects from enterotype 1 (Prevotella enterotype), concomitant to a decrease of Prevotella. [#Clostridium clusters XIVa] - Along with #Bifidobacterium, #Cranberry juice stimulated the growth of Prevotella, #Clostridium XIVa and #Eggerthella, while #Bacteroides was not affected by the #Cranberry juice intake. [1.79] [#CVD] [#Bacteroides-Prevotella group] - CAD > increased Prevotella genus, #Catenibacterium genus, #Pseudomonas genus, and #Subdoligranulum. - Individuals with high levels of #Bacteroides in the stool also have high #Cutibacterium on the skin and Prevotella in the oral microbiome. - The correlated #Bacteroides in the stool and #Cutibacterium in the skin are both closely related to lipid metabolism [1.81] [#Mild Cognitive Impairment, #Parkinson’s Disease] [#Porphyromonas gingivalis] - The structures of oral microbiota in PD-MCI group were significantly different compared to that in PD-NC and PC group. The relative abundances of Prevotella, #Lactobacillus, #Megasphaera, #Atopobium, and #Howardella were negatively correlated with cognitive score. - The predominant Kgp genotypes of P. gingivalis in the PD-MCI group were primarily Kgp II, whereas in the PD-NC group, it was mainly Kgp I. - The Kgp II correlated with lower MMSE and MoCA scores, which suggested that Kgp genotypes II is related to cognitive impairment in PD. [1.82] [#Multiple Sclerosis] [#Short Chain Fatty Acid] - the abundances of several of the major short-chain fatty acid (SFCA) producers were decreased (Prevotella and #Roseburia). [1.83] [#Schizophrenia] - Megasphera, #Akkermansia, #Fusobacterium and Prevotella were significantly more abundant in SCZ patients, and #Citrobacter, #Blautia, #Coprococcus, #Lachnoclostridium were more abundant in HC controls. [#Schizophrenia] [#Ruminococcus] - #Shigella and #Collinsella were more abundant in SCZ patients, and #Faecalibacterium, #Coprococcus, Prevotella, #Haemophilus, Ruminococcaceae_Ruminococcus, #Bacteroides, and #Oscillospira are significantly abundant in HC [1.84] [#Cirrhosis] [#Roseomonas mucosa] - In cirrhotic patients, the relative abundances of #Veillonella, #Megasphaera, #Dialister, #Atopobium, and Prevotella were increased in the duodenal mucosa [1.85] - acute and chronic #Nitrate exposure increased (representatives of) health-associated #Neisseria and #Rothia whilst reducing #Periodontal disease-associated Prevotella . [1.86] [#Bipolar disorder] - #Betaproteobacteria, #Acidaminococcaceae, #Eubacterium xylanophilum group, #Butyricimonas, #Peptococcus, Prevotella 7, #Roseburia, #Terrisporobacter, #Burkholderiales and #Desulfovibrionales increased the risk of BDReferences Notes[ ]
