Flavonoid {90000191}

Shared Reference Notes

• [1.1] 
  - Flavanols are bioactive food constituents and dietary sources include tea, cocoa, pome fruits, grapes and wine, and various grains, herbs, and berries.
• [1.2] [#Flavonoid-Rich Foods] 
  - Dietary flavonoids, a large group of plant-derived polyphenolic compounds, are commonly found in fruits, vegetables, tea, chocolate, and red wine. - Flavonoids are categorized into 6 main subclasses based on their chemical structure (flavonols, flavones, flavanones, flavan-3-ols, anthocyanins, and flavonoid polymers [procyanidins and other polymers]) which differ in bioavailability and biological activity. - Following ingestion, the majority of flavonoids interact with the gut microbiome, resulting in modulation of both the gut microbiome and the flavonoid structures, which are catabolized into metabolites with increased bioactivity
• [1.3] [#Systemic lupus erythematosus] [#Polyphenols] 
  - dietary polyphenol as dihydrochalcones and flavanones affected the gut microbiome and ameliorated lupus disease activity. - dietary flavones increased #Blautia (family: Lachnospiraceae), and that often found in active lupus diseases.
• [1.4] 
  - flavonoids, a group of natural compounds abundant in plants sources, such as bark, roots, stems, fruits, vegetables, bulbs, wine, and #Tea, have gained widespread attention for their therapeutic effects such as anti-oxidative, anti-inflammatory, cardioprotective, anti-estrogenic, neuroprotective, and chemoprotective roles
• [1.5] [#Colon adenomas] 
  - #Flavonifractor plautii appears to be linked to the degradation of beneficial anticarcinogenic flavonoids.
• [1.6] 
  - Other bioactive compounds from #Oat include #Vitamin E, flavonoids, phenolics, #Phytosterols, and avenanthramides
• [1.7] 
  - #Polyphenols exist in various forms including flavanols, flavanones and #Anthocyanins
• [1.8] [#Lactobacillus] 
  - flavanols can stimulate #Lactic acid bacteria.
• [1.9] 
  - Flavonoids derived from fruits and vegetables such as quercertin and #Resveratrol have been identified as #AHR ligands
• [#Akkermansia muciniphila] - #Silymarin/#Silibinin > dietary flavonoids or #Polyphenols > increase of ASV5 (A. muciniphila)
• [1.11] [#Parkinson’s Disease] 
  - higher habitual intakes of total flavonoid intake and, specifically #Anthocyanins (present in berries), were associated with a reduced PD risk of 40%, 24%, and 23% respectively.
• [#Parkinson’s Disease] - Flavonoids, such as #Naringenin and #Hesperetin, can reduce PD include their impact on #Oxidative stress that can result in chronic inflammation, interactions with neuronal signaling pathways, modulating the activity of several oxidative-related enzymes, and regulating mitochondrial function.
• [1.12] [#Kidney stone] [#Enterobacteriaceae bacterium, #Flavonifractor plautii] 
  - F. plautii enriched in Nephrolithiasis > is a flavonoid-degrading bacterium, but dietary plant flavonoids have been shown to be beneficial in stone and #Cancer cohorts, potentially reducing the incidence of CaOx stones through diuretic, anti-oxidant, and anti-inflammatory mechanisms.
• [1.13] [#Alzheimer’s disease] 
  - The flavonoid #Baicalein has also shown to inhibit microglia-induced neuroinflammation in a mouse model of AD by suppressing NLRP3 activation and the TLR4/NF-kB pathway
• - flavonoid #Galangin has shown to alleviate DSS-induced #Colitis’ symptoms in mice by increasing the expression of autophagy-related proteins and promoting colonic autophagosome formation
• [1.14] [#Elevated C-reactive protein] 
  - participants with higher CRP levels benefited less from flavonoid intake compared with those with lower CRP concentrations.
• [#Metabolic associated fatty liver disease] - the risk for NAFLD significantly decreased as flavonoid intake tertiles increased in a stepwise manner
• [1.15] [#Inflamatory bowel disease] 
  - #Broccoli, #Kale, radish, and #Cabbage are flavonoids-rich with #Quercetin and cyanidin, and #Polyphenols like ferulic, sinapic, and caffeic acids for #Prebiotic, endothelial and epithelial barrier protection, antioxidant, anti-inflammatory and anti-adhesive potential to complement the effect of ITCs against IBD

References Notes