Lactobacillus ⇒ Lactobacillus plantarum {10000147}

Shared Reference Notes

• [1.1] 
  - Ingesting Lactobacillus plantarum P-8 (P-8) improved stress/anxiety symptoms.
• [1.2] 
  - Lactobacillus plantarum strains are capable of BA metabolism, they can withstand BA associated stress and propagate, a recognised important characteristic for GIT survival.
• [1.3] [#Iron] [#Food Minerals] 
  Lactobacillus plantarum > Microbial metabolite production, enhanced mucin production and immunomodulation > Increased non-heme dietary Fe absorption.
• [1.4] [#Exercise training] 
• [1.5] 
  - Decreases in SCFA-producing bacteria, specifically belonging to #Akkermansia and #Faecalibacterium genera, have also been detected in mice subject to 7-day paradoxical #Sleep Deprivation and 3-day continuous #Sleep Deprivation. - Decreases in Bifidobacterium and Lactobacillus genera have been seen in mice subject to 5 days of sleep disruption. - #Sleep Deprivation–induced dysbiosis in mice resulted in increased intestinal permeability and reduced abundance of SCFAs, features that were both reversed following subsequent administration of Lactobacillus plantarum.
• [1.6] 
  - High #Proline consumption was the dietary factor with the strongest impact on #Depression. - #Proline supplementation in mice exacerbated #Depression along with microbial translocation. - RNAi-mediated knockdown of #Proline and GABA transporters in Drosophila and mono-association with L. plantarum, a high GABA producer, conferred protection against #Depression-like states.
• [1.7] [#Natural Skin Microbiome] 
  - #Probiotic Lactobacillus plantarum > transepidermal water loss (TEWL) was much less in the #Probiotic group at Week 12. Wrinkle depth significantly decreased in the #Probiotic group by Week 12, along with significant improvement in skin gloss. - skin elasticity, improved 13.17% in the #Probiotic group after 4 weeks, and 21.73% after 12 weeks > facial skin anti-aging.
• [1.8] 
  - only Lactobacillus plantarum seems to take part in the synthesis of #Acetylcholine.
• [1.9] [#UV radiation] 
  - Lactobacillus plantarum HY7714, #Bifidobacterium breve B-3 > skin protection. - there were functional substances in the skin–gut axis communication, which interact in a photoprotective manner, resulting in an anti-#Aging effect in a mouse model, and administration of Lactobacillus plantarum HY7714 can decrease the symptoms of UV-induced skin photo-#Aging in humans.
• - intake of Lactobacillus plantarum HY7714 for 12 weeks could significantly improve skin hydration, skin gloss, skin elasticity, and alleviate facial wrinkles compared with the placebo group
• [#UV radiation] - Lactobacillus plantarum had the potential to prevent UV-induced photoaging by inhibiting MMP-1 expression in fibroblast in mice.
• [#Streptococcus thermophilus] [#Cypto-chlorogenic acid] - mulberry #Anthocyanins were specifically transformed by S. thermophilus (46.2%) and L. plantarum (43.6%) into #Chlorogenic acid, cypto-#Chlorogenic acid, #Caffeic acid and #Ferulic acid: all #Phenolic acids with potent anti-inflammatory benefits.
• - L. plantarum can produce #Acetylcholine
• [#Catechins, #Phenolic acids, #Polymeric procyanidins] - L. plantarum IFPL935 was found to be important in the first step of catechin and procyanidin catabolism involving ring fission, however did not impact the production of phenolic metabolites unless in the context of a complete microbiota indicating that there is another microbe using the metabolic intermediate of L. plantarum to produce the bioactive metabolites.
• - toll-like receptor (TLR)2 signaling, activated by various gram-positive bacterial ligands such as #Lipoteichoic acid found on Lactobacillus plantarum strains, is required for the microbiota-mediated protection of the epithelial barrier and formation of tight junctions.
• [1.11] [#Cognitive impairment] 
  - Intake of Lactiplantibacillus plantarum LPHEAL9 significantly improved cognitive functions compared to the placebo, potentially by ameliorating aspects of mood and #Sleep.
• [1.12] [#Clostridioides difficile, #Lactobacillus bulgaricus, #Lactobacillus delbrueckii, #Limosilactobacillus (Lactobacillus) reuteri] 
  - There are several bacteria that can produce #Folate in the gut, which include #Bacteroides fragilis, #Prevotella copri, #Clostridium difficile, Lactobacillus Plantarum, L. reuteri, L. delbrueckii ssp. bulgaricus, #Streptococcus thermophilus, #Bifidobacterium spp. (some species), #Fusobacterium varium, and #Salmonella enterica
• [1.13] [#Autism] [#Bifidobacterium animalis, #Lactobacillus acidophilus, #Streptococcus thermophilus] 
  - Sptreptococcus thermophilus, #Bifidobacterium breve, B. animalis, #Lactobacillus helveticus, L. plantarum, L. acidophilus, and L. paracacei > attenuated the inflammatory responses in a VPA-induced rodent ASD model. - psychobiotic treatment decreased serum pro-inflammatory cytokine, #IL-6 levels, and increased anti-inflammatory cytokine, #IL-10 levels, with the improved status of diverse behavior tests including social interaction, #Anxiety, and repetitive behaviors
• - #Lactococcus lactis subsp. cremoris, L. lactis subsp. lactis, Lactobacillus plantarum, #Streptococcus thermophilus, #Escherichia coli, #Morganella morganii, #Klebsiella pneumoniae, and #Hafnia alvei produce #Serotonin
• [1.14] [#Colorectal cancer] 
  - Lactobacillus plantarum (L. plantarum) is a ##Probiotic that has emerged as novel therapeutic agents #Cancer effects by increasing the cytotoxicity and death of CRC cells or reducing NLRP3 and ERK phosphorylation.
• - L. plantarum metabolites can reverse altered glycolysis mechanisms, thereby decreasing #Cancer cell proliferation, increasing apoptosis, and decreasing chemoresistance. - L. plantarum metabolites appear to obstruct phagophore and autophagosome formation, including the steps of vesicle nucleation and vesicle elongation, resulting in decreased expression of autophagy proteins.
• - L. plantarum administration reduced the incidence of DSS-induced #Colitis. L. plantarum uptake maintained the integrity and permeability of intestinal epithelial cells and increased mucin secretion from goblet cells.
• [#Colorectal cancer] - L. plantarum reduced chronic mucosal inflammation and #Ulcerative Colitis symptoms. Chronic intestinal #inflammation is important because chronic intestinal inflammation can lead to the development of CRC
• [1.15] [#Antimicrobial peptides] 
  - AMPs produced by Lactobacillus plantarum were capable of modulating cytokine production in PBMCs, with an increase in the production of the anti-inflammatory cytokines #IL-10 and #IL-12 by over 10-fold.
• [1.16] [#Antibiotic Therapy] 
  - #Indole is a bacterial signaling molecule that has been shown to influence bacterial movement, biofilm formation, antibiotic resistance, and the colonization of #Staphylococcus aureus, #Salmonella enterica, and Lactobacillus plantarum
• [1.17] [#Clostridium aerotolerans] [#4-ethylphenol, #4-ethylphenylsulfate] 
  - other enzymes (e.g., vinylphenol reductase protein (VPR)) are rarer and encoded by only a few microbes (i.e., Lactobacillus plantarum, C. aerotolerans DSM 5434T and #Brettanomyces (Dekkera) yeasts) > increase 4EP
• [1.18] [#Essential tremor] 
  - administering the high-#GABA-producing L. plantarum strain L5 significantly ameliorated the tremors in ET mice by reshaping the gut microbial composition, enhancing the #GABA-producing capacity of the mucosa-associated microbiota, and elevating the #GABA concentrations in the cerebellum. - supplementation of L5 did not lead to any conspicuous increase in the plasma concentrations of #GABA in mice. - #GABA synthesized by the intestinal L5 was conveyed to the brain via the “enteric nervous system–vagus nerve–brain” axis and subsequently relieved the tremor. - the administration of L5 significantly elevated the relative abundance of several probiotics (e.g., Lactobacillus and Akkermansia), improved the small intestinal barrier, and attenuated neuroinflammation in ET mice.
• [1.19] [#Metabolic associated fatty liver disease] [#Lactobacillus bulgaricus, #Lactobacillus paracasei] 
  - Randomized controlled trials in NAFLD patients revealed that administration of polymicrobial probiotics (containing #Bifidobacteria, #Lactobacillus acidophilus, L. bulgaricus, L. paracasei, L. plantarum, and #Streptococcus thermophilus) significantly reduced the fatty liver phenotype, inflammation, and #Fibrosis.
• [#Lead] - L. plantarum CCFM8661 alleviate Pb toxicity by changing microbiota and metabolites > increase of #Bifidobacterium and decrease of #Bilophila > Increased metabolites include #Taurine and #Xanthine in colon, #Lauric acid in serum.
• [1.21] [#Tryptophan] 
  - #Lactococcus lactis subsp. cremoris (MG 1363), L. lactis subsp. lactis (IL1403), Lactobacillus plantarum (FI8595), #Streptococcus thermophilus (NCFB2392), #Escherichia coli K-12, #Morganella morganii (NCIMB, 10466), #Klebsiella pneumoniae (NCIMB, 673), and #Hafnia alvei (NCIMB, 11999) that can produce #Serotonin from Trp
• [1.22] [#Chloracidobacterium thermophilum B] 
  - Lactobacillus plantarum LC27 and #Bifidobacterium longum LC67 can inhibit NF-κB pathway to inhibit inflammatory response
• [1.23] [#Colitis] 
  - L. plantarum Δbsh 1 and Δbsh 3 treatments did not improve body weight and alleviate the hyperactivated myeloperoxidase activity to the DSS group.
• [1.24] [#Bacteroides dorei, #Clostridium symbiosum, #Lachnoclostridium clostridioforme] 
  - The absence of B. dorei impacted the abundance of the other 10 species negatively. - #Lachnoclostridium symbiosum, a #Butyrate producer, appeared to be the most sensitive species to deletions, being stimulated by the presence of #Escherichia coli, #Bifidobacterium adolescentis, B. dorei, and Lactobacillus plantarum.
• [1.25] 
  - treatment with #Lactobacillus plantarum L137 increased the abundance of #Lactobacillus species, improved intestinal barrier integrity via upregulation of #ZO-1, as well as modulated cytokine levels. - In #Colitis mice, treatment with #Lactobacillus plantarum L137 ameliorated disease-associated changes and exhibited an anti-inflammatory effect.
• [1.26] [#Cancer] [#Polysaccharide] 
  - #Rhamnose-rich polysaccharides (RHP) from a commensal strain of Lactiplantibacillus plantarum have now been shown to induce #Iron sequestration by tumor macrophages, thereby limiting tumor growth and promoting antitumor immunity.

References Notes