Tau {90000362}

Record Keys


Parent:[  ]
Definition:
Tau
Queue:[  ]

Details


Initialisation date:[  ]
Specification:
[  ]
Source:
[  ]

Meta Information


Structural Type:[  ]
Functional Type:[  ]
Function:[  ]

Notes:


[  ]

Shared Reference Notes


  • [1.1
    - Brain-derived tau is a new blood-based biomarker that outperforms plasma total-tau and, unlike neurofilament light, shows specificity to #Alzheimer’s disease-type neurodegeneration.
  • [1.2] [#Alzheimer’s disease] [#Short Chain Fatty Acid] [#ApoE4 allele
    - #Amyloid-beta is a necessary factor in AD pathogenesis, its accumulation in and of itself is insufficient for neurodegeneration and cognitive decline. - pathological tau accumulation is closely linked with neurodegeneration and cognitive decline in AD and primary tauopathies. - apolipoprotein E (ApoE) isoforms, which strongly influence AD risk and regulate tau-mediated neurodegeneration, differentially affect the gut microbiota. - microbially produced short-chain fatty acids (SCFAs) are mediators of the neuroinflammation-neurodegeneration axis. - Supplementation of SCFAs to GF TE4 mice resulted in more reactive glial morphologies and gene expression as well as increased p-tau pathology.
  • [1.3] [#Alzheimer’s disease] [#Amyloid-beta
    - adding #Cinnamon or cinnamaldehyde to a cell medium can reduce tau aggregation, Amyloid β and increase cell viability. - #Cinnamon might be useful for preventing and reducing cognitive function impairment.
  • [1.4] [#Alzheimer’s disease
    - the whole #Coffee extract, #Caffeine, and #Genistein have biological properties in preventing aggregation, condensation, and seeding activity of the repeat region of tau. - a set of #Coffee compounds capable of binding to preformed tau fibrils.
  • [1.5] [#Alzheimer’s disease
    - administrating feces of AD transgenic mice to wild-type mice resulted in AD-associated gut microbiota dysbiosis, Tau phosphorylation, and #Cognitive impairment in the wild-type mice. - The oral and gut microbiota of AD patient partners resembled that of AD patients but differed from healthy controls, indicating the transmission of microbiota. - #Butyric acid-mediated acetylation of GSK3β at lysine 15 regulated its phosphorylation at serine 9, consequently impacting Tau phosphorylation.
  • [1.6] [#Alzheimer’s disease
    - co-housing wild-type mice with AD transgenic mice or giving them AD transgenic mice feces caused AD-associated gut microbiota dysbiosis, Tau phosphorylation, and #Cognitive impairment. - Gavage with #Lactobacillus and #Bifidobacterium restored these changes.
  • [#Alzheimer’s disease] - #Butyric acid-mediated acetylation of GSK3β at lysine 15 regulated its phosphorylation at #Serine, consequently impacting Tau phosphorylation.

References Notes


[  ]
MetaBiom only uses strictly necessary session cookies to give you the best possible experience on the website. By selecting "Accept essential cookies" you agree to the use of these cookies.