Sign ⇒ Sarcopenia {40000580} Record Keys Type:Disease, Sign Parent:[ ] Definition:Sarcopenia Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - The genera Lachnospira, Fusicantenibacter, Roseburia, Eubacterium, and Lachnoclostridium—known #Butyrate producers—were significantly less abundant in Case and preCase subjects while Lactobacillus was more abundant. - Functional pathways underrepresented in Case subjects included numerous transporters and phenylalanine, tyrosine, and tryptophan biosynthesis suggesting that protein processing and nutrient transport may be impaired. -#Lipopolysaccharide biosynthesis was overrepresented in Case and PreCase subjects suggesting that sarcopenia is associated with a pro-inflammatory metagenome. [1.2] [#Faecalibacterium prausnitzii] [#Aging] - older subjects with physical #Frailty and sarcopenia > Lower abundance of F. prausnitzii, as well as members of the #Clostridiales class including #Eubacterium and #Roseburia genera. [1.3] - #Trigonelline improved grip strength and #Fatigue independently of changes in muscle mass and maximal tetanic strength. - benefits of #Trigonelline on muscle performance did not arise from structural adaptations in the skeletal muscle architecture, such as myofibre cross-sectional area, vascularization and fibrosis, but were linked to functional improvements of the mitochondrial respiratory activity of complexes I and II. - In humans, serum #Trigonelline levels are reduced with sarcopenia and correlate positively with #Muscle strength and mitochondrial oxidative phosphorylation in skeletal muscle. - #Trigonelline incorporates into the NAD+ pool and increases NAD+ levels in #Caenorhabditis elegans, mice and primary myotubes from healthy individuals and individuals with sarcopenia. [#Niacin] - Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD+) levels are hallmarks of skeletal muscle ageing and sarcopenia - #Trigonelline is particularly abundant in plant-derived food products, such as #Coffee beans and fenugreek seeds, which have been reported to modulate endogenous #Trigonelline levels in humans. - high #Coffee consumption has been associated with a lower prevalence of sarcopenia in some populationsReferences Notes[ ]
