Microbiome & Chronic Diseases

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Bacteroidaceae ⇒ Bacteroides {10000109}

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Anti fibrosis


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Shared Reference Notes

  • [1.1
    - The identified microbiome pattern of healthy ageing is characterized by a depletion of core genera found across most humans, primarily Bacteroides. - Retaining a high Bacteroides dominance into older age, or having a low gut microbiome uniqueness measure, predicts decreased survival in a 4-year follow-up.
  • [1.2
    - Patients with #Major depressive disorder showed a statistically significant overrepresentation of Bacteroides enterotype 2 compared to controls.
  • [1.3
    - Bacteroides is a common member of the gut microbiome and plays important, symbiotic roles, such as modulation and regulation of the immune system, maintenance of intestinal integrity, and carbohydrate digestion. - Bacteroides organisms are major producers of short-chain fatty acids, which have been shown to support host immune homeostasis both locally and systemically
  • - γ-aminobutyric acid (#GABA) production by human-derived Bacteroides is widespread, and there is a correlation between brain signatures of depression and fecal Bacteroides levels in patients with #Major depressive disorder.
  • [1.4] [#Non-alcoholic fatty liver disease
    - Some Bacteroides species have been reported to be protective against MAFLD
  • [#Steatohepatitis] - Bacteroides was negatively associated with advanced steatosis - Some species of Bacteroides have been associated with progression to advanced liver fibrosis
  • [1.5
    - Bacteroides predominate with protein and #Animal fat consumption.
  • [1.6] [#Galactooligosaccharides & modified mogrosides Sweetener
    - Significant growth during the fermentation at 10 h of bacterial populations includes #Bifidobacterium, Bacteroides, #Enterococcus, and #Clostridium coccoides. - significant increase in production of SCFA in mMV-GOS at 10 h of fermentation, mainly seen in #Acetate and #Propionate production
  • [1.7] [#Alzheimer’s disease
    - Increasing the relative abundance of Bacteroides and #Faecalibacterium may improve cognitive levels
  • [1.8
    - Members of the genera #Oscillospira and #Coprococcus in the cecum, as well as #Faecalibacterium prausnitzii and members of the genus Bacteroides in the ileum > negatively correlated with #Fibrosis.
  • [1.9] [#Carbohydrate diet, #High protein / animal fat diets
    - high protein animal fat diets are associated with Bacteroides, whereas diets high in carbohydrates are associated with a high prevalence of #Prevotella
  • [#Chronic fatigue syndrome] - Several studies reported a reduction of a butyrate-producing Bacteroides species in ME/CFS
  • [#Resistant starch] - RS consumption was associated with an increased abundance of either Bacteroides or #Prevotella transcripts.
  • [1.11
    - #Butyrate inhibits gut microbiome Bacteroides - #Butyrate inhibition depends on which #Sugar a given Bacteroides strain uses - Core genome variation in Acyl-CoA enzymes mediates #Butyrate defense - Each Bacteroides unique fitness landscape unpredictable by interaction of ecosystem parts
  • [1.12
    - #Firmicutes and Bacteroides are the main #Butyrate producing phyla
  • [1.13] [#Diabetes Type 1] [#Lipopolysaccharide
    - lipopolysaccharides biosynthesis in Bacteroides MAGs (metagenome-assembled genomes) and #Sulfate reduction in #Anaerostipes MAGs as functional signatures of MAGs with positive IA-association (Islets autoantibody)
  • [#Diabetes Type 1] [#Lipopolysaccharide] - LPS produced by the Bacteroides species in gut microbiota has immunoinhibitory properties that may impede early immune education and contribute to the development of T1D.
  • [1.14
    -The antibacterial and antitumor defensin (HBD1) showed decreased levels in #Prostate cancer patients, while others (HBD2 and 3) were considerably increased. - Abundance of #Staphylococcus, #Corynebacterium and #Oxyphotobacteria genera was significantly higher, the abundance of #Faecalibacterium and Bacteroides genera were significantly lower in prostate tumor samples compared to non-tumor samples. - Bacteroides, Parabacteroides and #Faecalibacterium abundance gradually decreased with the combined increase in HBD2 and HBD3. - Higher #Corynebacterium and #Staphylococcus abundances were measured together with higher HBD2 and HBD3 urinary levels.
  • [1.15] [#Parkinson’s Disease
    - an abundance of Bacteroides (Gram-negative bacteria present in the gut microbiome) is associated with the severity of motor symptoms in PD
  • [1.16] [#Irritable bowel syndrome
    - symptom severity is related to characteristic alterations of gut microbiota, including reduced diversity, reduced exhaled methane, relative reduction of #Methanobacteriales and #Prevotella enterotype, and abundance of Bacteroides enterotype. - Bacteroides were found to be increased in patients with IBS-D and were associated with mucosal low-grade inflammation.
  • [1.17] [#Animal fat consumption
    - diet with high content of animal fat was consumed Bacteroides-dominated enterotype was present
  • [1.18] [#Lipopolysaccharide] [#Antibiotic Therapy, #Condition of chronic stress
    - stressor exposed mice had significantly altered community structure of their gut microbiota, with decreased abundance of the genus Bacteroides and increased abundance of the genus #Clostridium. This was accompanied by increased circulating levels of IL-6 and monocyte chemoattractant protein 1 (MCP-1). - In a follow-up experiment, animals were fed an antibiotic cocktail in the morning and evening by oral gavage, beginning three days before the stressor and continuing to the end of the experiment. Antibiotic treatment prevented the increases in IL-6 and MCP-1. - mice receiving the stressor had elevated hepatic portal blood levels of LPS (from the gastrointestinal draining vein) and elevated mRNA expression of IL-1β, IL-6, and TNF in the hypothalamus, though no changes in circulating cytokines. Pretreatment with L. farciminis, antibiotics, and ML-7 all prevented these increases.
  • [1.19] [#CVD] [#Short Chain Fatty Acid] [#Probiotic, #Probiotic (Bifidobacter and Lactobacilus)
    - Short-chain fatty acids and secondary #Bile Acids can decrease #Cholesterol levels by regulating #Cholesterol metabolism. - Microbial #Bile Salt hydrolases can increase #Cholesterol disposal rates by accelerating its conversion to #Bile Acids. - Probiotics from the genera Lactobacillus and Bifidobacterium are efficient reducers of #Cholesterol levels in clinical studies. - Several candidate next-generation probiotics, including #Akkermansia muciniphila, Bacteroides spp., #Clostridium spp., #Christensenella minuta, Eubacterium spp., and #Faecalibacterium prausnitzii, have been shown to decrease #Cholesterol levels in human or animal studies.
  • - At the genus level, #Prevotella and Bacteroides were significantly enriched in the #Meditation group. - Two beneficial bacterial genera (#Megamonas and #Faecalibacterium) were significantly enriched in the #Meditation group. - Several pathways—including glycan biosynthesis, metabolism and lipopolysaccharide biosynthesis—were significantly enriched in the #Meditation group. - Plasma levels of clinical risk factors were significantly decreased in the #Meditation group, including total #Cholesterol and apolipoprotein B.
  • [1.21] [#Graves’ disease, #Graves’ orbitopathy
    - when patients were hyperthyroid and TRAB positive, #Actinobacteria were significantly increased and Bacteroidetes significantly decreased in GD/GO compared with HC. - Bacteroides displayed positive and negative correlations with TSH and FT4 respectively and was also significantly associated with #Smoking in GO, #Smoking is a risk factor for GO but not GD.
  • [1.22] [#Diabetes Type 2
    - The genus #Blautia was one of the most represented genera in both groups enriched in group T2D. - #Lachnoclostridium were more abundant in the microbiome profiles of diabetic patients. - There are anomalies in the genera Bacteroides and #Prevotella, both of which are increased in the T2D, both genera are #Propionate producers.
  • [1.23] [#Cesarean section, #Vaginally delivery
    - Bacteroides indeed disappears around week 1 of life in CS-born infants after initial colonization, whereas colonization persists in those vaginally born.
  • [1.24] [#Polyphenol] [#Polyphenol-rich supplementation
    - Four dietary polyphenols (rutin, #Quercetin, chlorogenic acid, and #Caffeic acid) can reduce the ratio of #Firmicutes to Bacteroides in in vitro gut microbiota experiments.
  • [1.25] [#Colitis, #Diabetes Type 1
    - The protein expressed by the Bacteroides is almost identical to a protein expressed by insulin-producing cells in the pancreas. - The CD8 lymphocytes can mistakenly attack the pancreatic cells and cause type 1 diabetes.

References Notes

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Common References