AHR {90000236}

Shared Reference Notes

• [1.1] [#Alzheimer’s disease, #Parkinson’s Disease] 
  - #Tryptophan metabolites can cross the blood-brain barrier > activate AHR to regulate astrocytes and reduce central nervous system inflammation in AD and PD
• [#Cancer] - AHR and its ligand activators have shown procancer activity, and ligand antagonists of AHR have the potential to become anticancer drugs
• [1.2] 
  - AHR is expressed by keratinocytes, epidermal Langerhans cells, dermal and epidermal innate and adaptive immune cells. - The activation of AHR is mostly anti-inflammatory through the regulation of cytokine production and other immune-related transcription factors, such as NF-κB. - In the skin epidermis, dead keratinocytes and broken keratin are used as substrates in the #Tryptophan metabolism of skin microbiota which leads to AHR agonists production

References Notes