Alcohol Consumption {50000121} Record Keys Definition:Alcohol Consumption Queue:[ ] Details Initialisation date:2019-05-12 Specification: [ ] Meta Information Type:Diet Host: Mouse Zone:[ ] Notes: - Acute-on-chronic alcohol administration induced shifts in various bacterial phyla in the cecum, including increased Actinobacteria and a reduction in Verrucomicrobia driven entirely by a reduction in the genus Akkermansia. (1)Shared Reference Notes [1.1] [1.2] - gut microbiota responds to #Ethanol-feeding by activating #Acetate dissimilation, not by metabolizing #Ethanol directly. - #Ethanol is not directly metabolized by the gut microbiota, and changes in the gut microbiota linked to #Ethanol are a side effect of elevated #Acetate levels. [1.3] [#Metabolic associated fatty liver disease] [#Bacteriophage] - high alcohol-producing #Klebsiella pneumoniae (HiAlc Kpn) in the intestinal microbiome could be one of the causes of non-alcoholic fatty liver disease (NAFLD). - treatment with HiAlc Kpn-specific phage was able to alleviate steatohepatitis caused by HiAlc Kpn, including hepatic dysfunction and expression of cytokines and lipogenic genes. [1.4] [#Cancer] - Genus #Neisseria had extremely high ADH activity and produced significant amounts of #Acetaldehyde in vitro. - #Neisseria’s ability to produce #Acetaldehyde was more than 100-fold higher than that produced by #Streptococcus sp., Stomatococcus sp., or #Moraxella sp. - #Neisseria can be a regional source of carcinogenic #Acetaldehyde and may thus play an essential role in alcohol-related carcinogenesis in humans [#Streptococcus gordonii, #Streptococcus mitis, #Streptococcus oralis, #Streptococcus salivarius, #Streptococcus sanguinis] - Several oral microbial species such as #Streptococci S. gordonii, S. mitis, S. oralis, S. salivarius, S. sanguinis, and #Candida yeasts possess the enzyme alcohol dehydrogenase (ADH), which metabolizes alcohol to #Acetaldehyde, which is indisputably carcinogenic. [1.5] [#Parkinson’s Disease] - that diets including a high intake of fruit, vegetables, legumes, wholegrains, #Nuts, fish, and poultry and a low intake of saturated fat and a moderate intake of alcohol could decrease the risk of PD. [1.6] - #Ethanol as the metabolite most affected by loss of cross-feeding in individuals with #Colorectal cancer (CRC). - Moderate to heavy alcohol consumption is associated with a 1.17 – 1.44 higher risk of developing CRC via a process that is at least partially mediated by the microbiome, as gut bacteria metabolise #Ethanol to produce the carcinogenic #Acetaldehyde [1.7] [#Blood Brain Barrier Integrity] [#Indole] - Alcohols promote dysbiosis and gut permeability and may alter the mucosal tight junctions and the immune activity in the GI tract, leading to a modification of gut barrier integrity, which allows microbial products such as indoles and FA to cross into the circulatory system [#Lipopolysaccharide] - Alcohols > alter the GM composition, stimulating the growth of Gram-negative facultative anaerobes producing exotoxins (i.e., lipopolysaccharides, LPS) [1.8] [#Inflamatory bowel disease] [#Dark chocolate, #Meat-based diet] - diet with citrus fruit, processed meat, #Gluten, chocolate, #Coffee, and alcoholic beverages are pointed out as dietary risk factors for both #Migraine and IBD in several studies [1.9] - #Klebsiella on skin was positively associated with metabolites of alcohol. - alcohol intake may change the host into a #Klebsiella-tolerant environment, resulting in the adaptation and expansion of pathogenic #Klebsiella [#Cancer, #Head & Neck cancer, #Oral cancer] - alcohol dehydrogenase enzyme found in different #Candida species enables them to produce #Acetaldehyde that is highly toxic, mutagenic, and carcinogenic [1.11] - an excessive intake of alcohol has been associated with elevated levels of #Holdemania in the gastrointestinal tract while causing a reduction in the concentration of #Butyric acid [1.12] - the alcohol group had higher #Lactobacillus and #Roseburia [#Corticosteroid ] - Alcohol-induced #Non-traumatic osteonecrosis of the femoral head showed elevated levels of L-Lysine and Oxoglutaric acid, while steroid-induced #Non-traumatic osteonecrosis of the femoral head had increased Gluconic acid and Phosphoric acid.References Notes (1) [1.13]
