Alcohol Consumption {50000121}

Record Keys


Definition:
Alcohol Consumption
Queue:[  ]

Details


Initialisation date:
2019-05-12
Specification:
[  ]

Meta Information


Type:
Diet
Host:
 Mouse
Zone:[  ]

Notes:


- Acute-on-chronic alcohol administration induced shifts in various bacterial phyla in the cecum, including increased Actinobacteria and a reduction in Verrucomicrobia driven entirely by a reduction in the genus Akkermansia. (1)

Shared Reference Notes


  • [1.1
  • [1.2
    - gut microbiota responds to #Ethanol-feeding by activating #Acetate dissimilation, not by metabolizing #Ethanol directly. - #Ethanol is not directly metabolized by the gut microbiota, and changes in the gut microbiota linked to #Ethanol are a side effect of elevated #Acetate levels.
  • [1.3] [#Metabolic associated fatty liver disease] [#Bacteriophage
    - high alcohol-producing #Klebsiella pneumoniae (HiAlc Kpn) in the intestinal microbiome could be one of the causes of non-alcoholic fatty liver disease (NAFLD). - treatment with HiAlc Kpn-specific phage was able to alleviate steatohepatitis caused by HiAlc Kpn, including hepatic dysfunction and expression of cytokines and lipogenic genes.
  • [1.4] [#Cancer
    - Genus #Neisseria had extremely high ADH activity and produced significant amounts of #Acetaldehyde in vitro. - #Neisseria’s ability to produce #Acetaldehyde was more than 100-fold higher than that produced by #Streptococcus sp., Stomatococcus sp., or #Moraxella sp. - #Neisseria can be a regional source of carcinogenic #Acetaldehyde and may thus play an essential role in alcohol-related carcinogenesis in humans
  • [#Streptococcus gordonii, #Streptococcus mitis, #Streptococcus oralis, #Streptococcus salivarius, #Streptococcus sanguinis] - Several oral microbial species such as #Streptococci S. gordonii, S. mitis, S. oralis, S. salivarius, S. sanguinis, and #Candida yeasts possess the enzyme alcohol dehydrogenase (ADH), which metabolizes alcohol to #Acetaldehyde, which is indisputably carcinogenic.
  • [1.5] [#Parkinson’s Disease
    - that diets including a high intake of fruit, vegetables, legumes, wholegrains, #Nuts, fish, and poultry and a low intake of saturated fat and a moderate intake of alcohol could decrease the risk of PD.
  • [1.6
    - #Ethanol as the metabolite most affected by loss of cross-feeding in individuals with #Colorectal cancer (CRC). - Moderate to heavy alcohol consumption is associated with a 1.17 – 1.44 higher risk of developing CRC via a process that is at least partially mediated by the microbiome, as gut bacteria metabolise #Ethanol to produce the carcinogenic #Acetaldehyde
  • [1.7] [#Blood Brain Barrier Integrity] [#Indole
    - Alcohols promote dysbiosis and gut permeability and may alter the mucosal tight junctions and the immune activity in the GI tract, leading to a modification of gut barrier integrity, which allows microbial products such as indoles and FA to cross into the circulatory system
  • [#Lipopolysaccharide] - Alcohols > alter the GM composition, stimulating the growth of Gram-negative facultative anaerobes producing exotoxins (i.e., lipopolysaccharides, LPS)
  • [1.8] [#Inflamatory bowel disease] [#Dark chocolate, #Meat-based diet
    - diet with citrus fruit, processed meat, #Gluten, chocolate, #Coffee, and alcoholic beverages are pointed out as dietary risk factors for both #Migraine and IBD in several studies
  • [1.9
    - #Klebsiella on skin was positively associated with metabolites of alcohol. - alcohol intake may change the host into a #Klebsiella-tolerant environment, resulting in the adaptation and expansion of pathogenic #Klebsiella
  • [#Cancer, #Head & Neck cancer, #Oral cancer] - alcohol dehydrogenase enzyme found in different #Candida species enables them to produce #Acetaldehyde that is highly toxic, mutagenic, and carcinogenic
  • [1.11
    - an excessive intake of alcohol has been associated with elevated levels of #Holdemania in the gastrointestinal tract while causing a reduction in the concentration of #Butyric acid

References Notes


  • (1) [1.12

Common References


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