Veillonellaceae ⇒ Megasphaera {10000959} Record Keys Parent:Veillonellaceae Definition:Megasphaera Details Initialisation date:[ ] Meta Information Rank: Genus Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - Megasphaera is consistently associated with advanced MAFLD and #Steatohepatitis [1.2] [#Inflamatory bowel disease] [#Short Chain Fatty Acid] The first signs of aggravation of IBD are : - a loss of the main anti-inflammatory Short-Chain Fatty Acids (SCFAs) #Roseburia, #Eubacterium, #Subdoligranumum, #Ruminococcus - an increase in pro-inflammatory pathogens #Proteus, #Finegoldia - an increase of other minor SCFA producers such as #Ezakiella, #Anaerococcus, Megasphaera, #Anaeroglobus, #Fenollaria. - Further aggravation of clinical signs is significantly linked to the subsequent loss of these minor SCFAs species and to an increase in other proinflammatory Proteobacteria such as Klebsiella, Pseudomonas, Salmonella, Acinetobacter, Hafnia and proinflammatory Firmicutes such as Staphylococcus, Enterococcus, Streptococcus. [1.3] [#Bipolar disorder, #Major depressive disorder, #Schizophrenia] - MDD and SZ shared higher levels of #Escherichia/#Shigella and #Veillonella whereas increased Megasphaera and lower #Roseburia are common for BD and SZ. [1.4] [#Metabolic associated fatty liver disease] - #Dorea, #Lactobacillus and Megasphaera are enriched in MAFLD group. [1.5] [#Parkinson’s Disease] - abundance of Megasphaera and #Akkermansia, and reduced #Roseburia in PD patients [1.6] - Megasphaera is associated with #Cognitive impairment and inflammation in patients with #Hepatic encephalopathy. [#Short Chain Fatty Acid] - genera #Lactobacillus and Megasphaera are increased in #Schizophrenia (SZ), as well as alterations in the #Glutamate-#Glutamine-#GABA cycle, serum levels of #Tryptophan, #kynurenic acid (KYNA), and short-chain fatty acids (SCFAs). [1.7] [#Chronic periodontitis] - the microbiomes of periodontitis patients contained a greater abundance of the genus #Acidaminococcus, #Clostridium, #Lactobacillus, #Bifidobacterium, Megasphaera, and Romboutsiac. [1.8] [#Mild Cognitive Impairment, #Parkinson’s Disease] [#Porphyromonas gingivalis] - The structures of oral microbiota in PD-MCI group were significantly different compared to that in PD-NC and PC group. The relative abundances of #Prevotella, #Lactobacillus, Megasphaera, #Atopobium, and #Howardella were negatively correlated with cognitive score. - The predominant Kgp genotypes of P. gingivalis in the PD-MCI group were primarily Kgp II, whereas in the PD-NC group, it was mainly Kgp I. - The Kgp II correlated with lower MMSE and MoCA scores, which suggested that Kgp genotypes II is related to cognitive impairment in PD. [1.9] [#Cirrhosis] [#Roseomonas mucosa] - In cirrhotic patients, the relative abundances of #Veillonella, Megasphaera, #Dialister, #Atopobium, and #Prevotella were increased in the duodenal mucosa [#Corticosteroid ] - the steroid group had more Megasphaera and #Akkermansia.References Notes[ ]
