Acetylcholine {90000146}

Shared Reference Notes

• [1.1] 
  - #Lactobacillus can produce acetylcholine
• [1.2] 
  - Acetylcholine is produced from #Lactobacillus
• [1.3] [#Lipopolysaccharide] 
  - Vagus nerve stimulation decreases the neuroinflammatory response to systemic administration of lipopolysaccharides and induces an anti-inflammatory microglial phenotype in an AD model. - Stimulation of the vagus nerve > release acetylcholine, which has an anti-inflammatory effect on macrophage gene expression in the periphery.
• [1.4] [#kynurenic acid] 
  - KYNA acts as an NMDA receptor antagonist or through the inhibition of the α7 nicotinic acetylcholine (α7nACh) receptors.
• [#Bipolar disorder] - in BD > Especially, #GABA, #Glutamate, #Serotonin, #Dopamine, norepinephrine and acetylcholine appears to be importantly dysregulated in these patients
• - only #Lactobacillus plantarum seems to take part in the synthesis of acetylcholine.
• [1.5] [#Lactobacillus plantarum] 
  - L. plantarum can produce acetylcholine
• [1.6] 
  - #Lactobacillus species produce acetylcholine and #GABA
• [1.7] [#Noradrenalin, #Serotonin] [#Keto diet] 
  - concentrations of 5-HT, NE, AC, and cAMP of SHR in the KD group were strikingly higher than that in the ND group.
• [1.8] 
  - #Acetate metabolism is an important metabolic pathway in many cancers and is controlled by acetyl-CoA synthetase 2 (ACSS2), an enzyme that catalyzes the conversion of #Acetate to acetyl-CoA. - blocking ACSS2, switches #Cancer cells from #Acetate consumers to producers of #Acetate thereby freeing #Acetate for tumor-infiltrating lymphocytes to use as a fuel source.

References Notes