Microbiome & Chronic Diseases

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Acetylcholine {90000146}

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Shared Reference Notes

  • [1.1
    - #Lactobacillus can produce acetylcholine
  • [1.2
    - Acetylcholine is produced from #Lactobacillus
  • [1.3] [#Lipopolysaccharide
    - Vagus nerve stimulation decreases the neuroinflammatory response to systemic administration of lipopolysaccharides and induces an anti-inflammatory microglial phenotype in an AD model. - Stimulation of the vagus nerve > release acetylcholine, which has an anti-inflammatory effect on macrophage gene expression in the periphery.
  • [1.4] [#kynurenic acid
    - KYNA acts as an NMDA receptor antagonist or through the inhibition of the α7 nicotinic acetylcholine (α7nACh) receptors.
  • [#Bipolar disorder] - in BD > Especially, #GABA, #Glutamate, #Serotonin, #Dopamine, norepinephrine and acetylcholine appears to be importantly dysregulated in these patients
  • - only #Lactobacillus plantarum seems to take part in the synthesis of acetylcholine.
  • [1.5] [#Lactobacillus plantarum
    - L. plantarum can produce acetylcholine
  • [1.6
    - #Lactobacillus species produce acetylcholine and #GABA
  • [1.7] [#Noradrenalin, #Serotonin] [#Keto diet
    - concentrations of 5-HT, NE, AC, and cAMP of SHR in the KD group were strikingly higher than that in the ND group.
  • [1.8
    - #Acetate metabolism is an important metabolic pathway in many cancers and is controlled by acetyl-CoA synthetase 2 (ACSS2), an enzyme that catalyzes the conversion of #Acetate to acetyl-CoA. - blocking ACSS2, switches #Cancer cells from #Acetate consumers to producers of #Acetate thereby freeing #Acetate for tumor-infiltrating lymphocytes to use as a fuel source.

References Notes

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Common References