Microbiome & Chronic Diseases

Evidence Based Medicine
Sign in

Glucose {90000189}

Record Keys

Parent:[  ]
Queue:[  ]


Initialisation date:
[  ]
[  ]

Meta Information

Structural Type:
Functional Type:
Energy Source
Function:[  ]


[  ]

Shared Reference Notes

  • [1.1
    - A high-glucose maternal diet > enrichment of #Isobaculum in the infant gut microbiome.
  • [1.2] [#Anorexia nervosa] [#Bacteroides vulgatus
    - in AN > Serum #Leucine mediated the influence of B. vulgatus counts on glucose homeostasis.
  • [1.3] [#Alzheimer’s disease] [#Adult age
    - A 15 mg/dL increase in high density lipoprotein (HDL) #Cholesterol was associated with decreased AD risk during earlyand middle adulthood. - A 15 mg/dL increase in glucose measured during middle adulthood was associated with 14.5% increased AD risk .
  • [1.4] [#Diabetes Type 2, #Obesity
    - Microbial homeostasis is normally maintained by peroxisome proliferator-activated receptor gamma (PPAR-γ). - PPAR-γ is a nuclear receptor activated by #Butyrate and other ligands, is found in adipocytes and colonocytes, and is responsible for activating genes involved in glucose and lipid metabolism.
  • [1.5] [#Diabetes Type 2] [#Short Chain Fatty Acid
    - SCFA #Acetate activates GPR43, promoting GLP-1 release from colonic L cells.
  • [#Diabetes Type 2] - activation of GPR41 by #Propionate or #Butyrate can induce both GLP-1 and peptide YY secretion from L cells in the small intestine.
  • [#Diabetes Type 2] [#Olive] - EVOO added to meals was associated with a reduction in blood glucose, #Triglyceride, apolipoprotein B-48, and dipeptidyl peptidase-4 activity levels and a significant increase in insulin and glucagon-like peptide 1 (GLP-1) levels in the peripheral blood.
  • [#Obesity] [#Olive] - The major fatty acid in EVOO, #Oleic acid, assists in maintaining glucose homeostasis by activating the G protein–coupled receptors GPR-120 and GPR-40, leading to intestinal GLP-1 release and widespread ant-inflammatory effects in a variety of tissues, including liver and adipose tissue.

References Notes

[  ]