Disease ⇒ Keratitis {40000384}

Shared Reference Notes

• [1.1] 
  - Megomonas has been isolated from human and animal intestines, a study showed it may play a protective role in #Glaucoma and keratitis. - There was a positive correlation between decreased #Citric acid and #Megamonas. - It was proven that the #Citric acid cycle plays a pivotal role in regulating energy homeostasis and cell metabolism, which is correlated with the mitochondrial dysfunction of glaucom.
• - #Acinetobacter exhibited a significant increase in abundance in Fungal Keratitis.. - #Acinetobacter can cause endophthalmitis > an opportunistic pathogens in conjunctivitis, keratitis, and endophthalmitis
• - #Acinetobacter and #Bacteroidetes are “biomarkers ”for the Fungal Keratitis.
• - conjunctival swabs from Bacterial Keratitis patients contained significantly less #Actinobacteria and #Corynebacteria (determinate beneficial symbiotic #Bacteria), but significantly more #Gammaproteobacteria, #Pseudomonas, #Bacteroides, and EscherichiaShigella (common ocular pathogenic #Bacteria).
• - #Lactobacillus, #Bacillus, #Corynebacterium, #Streptococcus, #Pseudomonas, #Staphylococcus, #Escherichia-#Shigella were observed to decrease in Viral Keratitis microbiomes. And the abundance of some opportunistic pathogens such as #Rhodococcus were increased.
• - the bacterial keratitis group had a significantly higher abundance of #Bacillus and #Megamonas.
• - abundance of #Rhodococcus increased in the Fungal Keratitis, which was related to the suppression of immune function in the patients.
• [#Staphylococcus epidermidis] - The eyes with Fungal Keratitis in the study showed a lower abundance of #Staphylococcus. - #Staphylococcus epidermidis was reported to be skin commensal and could offer heterologous protection against pathogenic fungal infections through induction of #IL-17A + CD8 + T cells.

References Notes