Beta-glucan {90000274}

Shared Reference Notes

• [1.1] 
  - Beta-glucan food supplement > significant decrease in the Childhood #Autism Rating Scale score in all of the children of the Nichi Glucan Gr.2 compared with the control. Plasma levels of #Alpha-synuclein were significantly higher in (Nichi Glucan) than in the control group.
• [1.2] 
  - Barley contains abundant soluble beta-glucan fibers - #Bifidobacterium, #Butyricicoccus, #Collinsella, #Ruminococcus 2, and #Dialister were characteristic candidate bacterias of the group that consumed large amounts of barley. - The relationship between #Barley consumption and #Bifidobacterium remained after adjusting for disease and dietary habits, and that of #Butyricicoccus remained after adjusting for disease. - Network and cluster analyses revealed that #Barley consumption was directly correlated with #Bifidobacterium and #Butyricicoccus.
• [1.3] [#Autism] [#Alpha-synuclein, #Amyloid, #Curli] [#Nichi Glucan] 
• [1.4] 
  - #Candidalysin, a peptide toxin secreted by the commensal gut fungus #Candida albicans, was found to enhance alcohol-associated liver disease independent of the β-glucan receptor CLEC7A, and is also associated with worse clinical outcomes in patients with #Alcoholic Hepatitis.
• [#Diabetes Type 2] - Enrichment of #Candida albicans in samples from individuals with T2D. - Repopulation with C. albicans in HFD mice accelerated insulin resistance and related disorders. - β-glucan from C. albicans mirrored the deteriorating effect of C. albicans through the dectin-1 dependent pathway.
• [1.5] 
  - #Oat β-glucan has demonstrated immunomodulatory, anti-inflammatory, and antioxidant effects
• - #Oat bran increased the proliferation of #Bifidobacterium adolescentis after in vitro fermentation, but β-glucan alone did not
• [#Hypercholesterolaemia] [#Oat] - Oats could be considered a functional food because of the presence of β-glucan, a soluble fiber shown to reduce #Cholesterol
• [1.6] 
  - β-glucan consumption could reduce the level of total #Cholesterol and LDL
• [1.7] [#Short Chain Fatty Acid] 
  - increased levels of total SCFAs and #Butyrate in mice that had received the beta-glucan intervention.
• - increase in #Lachnospiraceae, #Ruminococcaceae, and #Lactobacillus species following beta-glucan treatment.
• [#Liver fibrosis, #Metabolic associated fatty liver disease] - reduced abundance of TLR4 ligands in the serum and reduced hepatic TLR expression in mice treated with beta-glucan, which suggests a decrease in bacterial translocation due to restored intestinal homeostasis. - TLR4 ligands as an essential driver for intrahepatic fibrosis through the recruitment of Kupffer cells and hepatic stellate cells. - mice treated with beta-glucan > significant reduction in MoMFs and Kupffer cells, which are well-established drivers of MASLD progression.
• [#Metabolic associated fatty liver disease] - increased abundance of #Ruminococcus following beta-glucan treatment > improvement in MASLD progression.
• [#Obesity] - increased feelings of satiety and reduced food ingestion in probands following a diet with supplemented Beta-glucan. - Beta-glucan slows the gastric passage and reduces glycemic and insulinemic responses.
• [#Western-style diet] - significant reduction of #Ruminococcus in the mice that had been fed WSD in comparison to the control group. - This shift was partially reversed after beta-glucan treatment

References Notes