Roseburia ⇒ Roseburia intestinalis {10000245}

Shared Reference Notes

• [1.1] 
  - the abundance of Roseburia intestinalis is negatively correlated with the size of atherosclerotic lesions in the mouse model of #Atherosclerosis. - when Roseburia intestinalis was taken along with a high-fiber diet, aortic atherosclerotic plaques were reduced in size. This study suggests that the butyrate, a microbial metabolite, mediates these effects
• - The most prominent butyrogenic bacteria groups are #Faecalibacterium prausnitzii, #Butyrivibriocrossotus and Roseburia intestinalis which several studies have reported the depletion of these bacteria in atherosclerosis
• [1.2] 
  - Roseburia intestinalis specifically able to metabolize the indigestible glycans β-mannans found in #Nuts into #Butyrate
• [1.3] [#Parkinson’s Disease] 
  - At one end of the spectrum, #Bifidobacterium dentium was elevated by 7-fold, #Actinomyces oris by 6.5-fold, #Streptococcus mutans by 6-fold. At the other end of the spectrum, Roseburia intestinalis was reduced by 7.5-fold, and #Blautia wexlerae by 5-fold.
• [1.4] [#Anorexia nervosa] 
  - In AN, #Roseburia inulinivorans and Roseburia intestinalis were depleted
• [1.5] [#Colon adenomas] 
  - #Flavonifractor plautii, #Bilophila wadsworthia, #Bacteroides stercoris, #Clostridium asparagiforme, #Clostridium bolteae CAG 59 and Roseburia intestinalis were more common in people with tubular adenomas. - Tubular adenomas, instead, were linked to a reduction in a process called methanogenesis
• [1.6] [#Mild Cognitive Impairment] 
  - the abundance of #Butyrate producing bacteria such as #Lachnospiraceae family, #Subdoligranulum sp., Roseburia intestinalis, and #Roseburia hominis were reduced in the gut of MCI participants compared to cognitively healthy controls.
• [1.7] [#Acute lymphoblastic leukemia] [#Bacteroides ovatus, #Pseudomonas aurantiaca, #Roseburia inulinivorans] 
  - #Children with ALL exhibit reduced relative abundance of both #Butyrate-producing species (#Roseburia faecis, R. intestinalis, R. inulinivorans, #Anaerostipes hardus, #Faecalibacterium prausnitzii, #Eubacterium ramulus) and #Acetate-producing species (#Prevotella maculosa, P. aurantiaca, #Bacteroides uniformis, B. ovatus)
• [1.8] [#Systemic lupus erythematosus] 
  - β2GPI-reactive memory CD4+ memory T cell clones and APS-derived β2GPI autoantibody cross-reacted with mimotopes expressed by a gut commensal Roseburia intestinalis. - oral gavage of (NZW x BXSB)F1 mice with Roseburia intestinalis led to increased anti-human β2GPI IgG autoantibodies and thrombotic events.
• [1.9] 
  - Some specific gut microbes, such as #Akkermansia muciniphila, #Bacteroides vulgatus, #Bacteroides dorei, and Roseburia intestinalis are associated with the development of #Atherosclerosis.
• [#Juvenile idiopathic arthritis] - ABIS JIA had higher abundance of #Acidaminococcales, #Prevotella 9, and #Veillonella parvula and lower abundance of #Coprococcus, #Subdoligranulum, #Phascolarctobacterium, #Dialister spp., #Bifidobacterium breve, #Fusicatenibacter saccharivorans, Roseburia intestinalis, and #Akkermansia muciniphila
• [1.11] [#Diabetes Type 2] 
  - in T2DM patients > #Bifidobacterium, #Lactobacillus, #Faecalibacterium prausnitzii, and #Butyrate-creating bacteria such as Roseburia intestinalis and F. prausnitzii abundance decreased
• [1.12] 
  - #Eubacterium rectale and Roseburia intestinalis, that were negatively correlated with SMR during the study period. - reduction of these species was associated with severer #Covid-19 manifestation.
• [1.13] [#Crohn’s disease] 
  - links between Roseburia intestinalis and CD confirmed.
• [1.14] [#Bilirubin, #Urobilin ] 
  - The majority of bilR genes were identified in #Firmicutes species, including common human gut species such as Roseburia intestinalis, #Roseburia inulinivorans and #Faecalibacterium prausnitzii.
• [1.15] [#Bifidobacterium longum] [#Homovanillic acid] 
  - R. intestinalis does not directly produce HVA, it enhances B. longum abundance, leading to HVA generation.
• [#Bifidobacterium longum] [#Homovanillic acid] - Administering HVA, B. longum, or R. intestinalis to mouse models with chronic unpredictable mild stress (CUMS) and corticosterone (CORT)-induced #Depression significantly improved depressive symptoms. - HVA inhibited synaptic autophagic death by preventing excessive degradation of microtubule-associated protein 1 light chain 3 (LC3) and SQSTM1/p62 proteins, protecting hippocampal neurons’ presynaptic membrane.

References Notes