Clostridiales ⇒ Lachnospiraceae {10000240}

Shared Reference Notes

• [1.1] [#Systemic lupus erythematosus] 
  - Many Lupus patients have little or no detectable perturbations in representation of the Lachnospiraceae family or abundance of #Ruminococcus gnavus species overtime.
• [1.2] [#Crohn’s disease] [#Escherichia coli] [#Fecal Microbiota Transplantation] 
  - Comprehensive overview of functional dysbiosis in the gut microbiome during IBD activity showed increases in facultative anaerobes, such as E. coli which correlates with inflammation status, and decreases in obligate anaerobes, such as #Faecalibacterium prausnitzii and #Roseburia hominis -The results of the present study confirmed decreases in the abundance of Firmicutes and Bacteroidetes, increases in Enterobacteriaceae, Pasteurellaceae, and Veillonellaceae and the presence of Fusobacterium in stool samples of CD patients. - #Butyrate-producing bacteria are depleted in IBD patients, and probiotic treatment with these bacteria has therapeutic potential. - A higher proportion of Lachnospiraceae in donor stool was associated with a higher success rate of FMT, and recipients that responded to FMT exhibited increases in #Butyrate-producing Lachnospiraceae and Ruminococcaceae. - The reduced SCFA levels in patients with IBD result from lower abundance of SCFA-producing bacteria, especially those of the phylum Firmicutes. - #Butyrate can act as an energy source for normal colon epithelial cells, promoting their proliferation, but can also inhibit proliferation and induce apoptosis.
• [1.3] 
  - Blautia, Coprococcus, Dorea, Lachnospira, Oribacterium, Roseburia, and L-Ruminococcus (Ruminococcus genus assigned to the Lachnospiraceae family) are the main genera that have been detected in the human intestine by metagenomics analyses. - All members of Lachnospiraceae are anaerobic, fermentative, and chemoorganotrophic, and some display strong hydrolyzing activities, through the activity of pectin methyl-esterase, pectate lyase, xylanase, α-L-arabinofuranosidase, β-xylosidase α- and β-galactosidase, α- and β-glucosidase, N-acetyl-β-glucosaminidase, or α-amylase. - Lachnospiraceae are present in early infants, found even in the meconium. - increases in Lachnospiraceae abundances are associated with aging. - Lachnospiraceae abundance also increases in the intestinal lumen of subjects with different diseases, although the taxa of this family have repeatedly shown their ability to produce beneficial metabolites for the host.
• [1.4] 
  - Different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol. - Lachnospiraceae is associated with lipid cardiovascular risk factors.
• [1.5] 
  - Dietary fiber, magnesium, and potassium > inversely abundance of Lachnospiraceae
• [#Maternal consumption of dietary fibre] - Higher maternal consumption of dietary fiber > infant > Lower Lachnospiraceae count.
• [1.6] [#Inflamatory bowel disease] 
  - Seven bacterial species correlated with expression levels of Th17 effector cytokines, IL-17A and IL-17F. - The seven associated species include #Ruminococcus gnavus, #Escherichia coli, Lachnospiraceae bacterium, #Clostridium hathewayi, #Bacteroides faecis, #Bacteroides vulgatus, and #Akkermansia muciniphila. All of the species were positively associated with IL-17A/ IL-17F except #Akkermansia muciniphila, suggesting these species are proinflammatory, while #Akkermansia muciniphila is anti-inflammatory.
• [1.7] [#Parkinson’s Disease] 
  - Decreased Lachnospiraceae > reduction in anti-inflammatory and neuroprotective metabolite in PD Increased Bacteroides and Verrucomicrobia > Metabolites correlated positively with the frequency of the proinflammatory cytokines TNF-α and IFN-γ
• [1.8] 
  - #Protein powder consumption > decrease in Lachnospiraceae, #Roseburia, #Blautia, Synergistales, #Coprococcus, #Lactobacillales, Bacilli, #Bifidobacterium longum and #Firmicutes. - #Protein powder consumption > higher abundance of #Bacteroidetes.
• [1.9] 
  - 4 weeks of #Grape powder consumption > significantly increased the alpha diversity index of the gut microbiome > increasing #Verrucomicrobia at the phylum level, and a significant increase in #Akkermansia and increase in #Flavonifractor and Lachnospiraceae_UCG-010 > decrease in #Bifidobacterium and #Dialister at the genus level.
• [#Gastric carcinoma] - #Aquabacterium, #Streptococcus and Lachnospiraceae > predict gastric cancer. - patients with low levels of #Streptococcus and Lachnospiraceae > more likely to live with gastric cancer without it getting worse. - Patient > more bacterial genes involved in the breakdown of #D-galacturonate > play a key role in the development of gastric cancer
• [1.11] [#Psychogenic erectile dysfunction] 
  - Erectile dysfunction > no #Alloprevotella . - Erectile dysfunction > increased #Streptococci and #Subdoligranulum - Erectile dysfunction > decreased #Prevotella sp.9, #Blautia, Lachnospiraceae NK4A136 groups and #Roseburia.
• [1.12] [#Infectious diarrhea] 
  - A drastic disappearance of obligate anaerobic gut commensals (#Blautia, #Prevotella, #Faecalibacterium, Lachnospiraceae, #Ruminococcaceae, etc.), leading to a depletion of associated metabolites such as #Short Chain Fatty Acid (SCFAs)
• [1.13] [#Cognitive impairment] 
  - #Barnesiella was positively associated with the first principal component, DSST, and category fluency; - Lachnospiraceae FCS020 group was positively associated with DSST. - #Sutterella was negatively associated with MoCA
• [1.14] [#Amyotrophic lateral sclerosis] 
  - ALS in mice> altered bacterial community related to autoimmunity (e.g., #Clostridium sp. ASF502, Lachnospiraceae bacterium A4), inflammation (e.g., #Enterohabdus Muris,), and metabolism (e.g., #Desulfovibrio fairfieldensis) at 1- and 2-month-old SOD1G93A mice, suggesting the early microbial contribution to the pathological changes.
• [1.15] [#Heart failure] [#Eubacterium hallii, #Ruminococcaceae] 
  - patients with HF have a decrease in #Butyrate-producing bacteria, especially, Lachnospiracea and Ruminococcacea families. - reduction of the #Butyrate-producing Eubacterium Halli and Lachnospiracea is correlated with increased inflammation, severity of disease, heart damage and mortality
• - bacteria with capacity of butyrate production, Lachnospiraceae and #Ruminococcaceae, were depleted in individuals at a high risk of #Stroke. Fecal butyrate concentrations also were low in these people
• [1.16] [#Parkinson’s Disease] 
  - #Prevotellaceae (Prevotella), #Ruminococcaceae (#Faecalibacterium), Lachnospiraceae (#Blautia, #Roseburia) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD
• [1.17] [#Inflamatory bowel disease, #Systemic anti-microbiota IgG] 
  - a modified high-throughput, culture-independent approach to quantify systemic IgG against gut commensal bacteria in human serum samples without the need for paired stool samples. - Using this approach, we highlight several commensal bacterial species that elicit elevated IgG responses in patients with inflammatory bowel disease (IBD) including taxa within the clades #Collinsella, #Bifidobacterium, Lachnospiraceae, and #Ruminococcaceae.
• [1.18] [#Multiple Sclerosis] 
  - Faecalibacteria, Lachnospiraceae, and #Anaerostipes produce butyrate, which acts via G-protein coupled receptors activation and histone deacetylase inhibition to suppress CNS demyelination, the main pathological feature in MS.
• [1.19] [#Rheumatoid Arthritis] 
  -IgG and IgA autoantibodies from individuals who are at risk for RA cross-react against gut bacteria in the Lachnospiraceae and #Ruminococcaceae families. - Analysis identified a bacterial strain from the #Subdoligranulum genus that was associated with autoantibody development. - Mice colonized with this #Subdoligranulum isolate developed arthritis with pathology similar to human RA.
• - #Obesity > expansion of Escherichia shigella in obese patients compared to healthy controls. - The family #Eubacterium coprostanoligenes and #Tannerellaceae, the genera #Eubacterium coprostanoligenes, Lachnospiraceae NK4A136, #Parabacteroides, and Akkermansia, and the species #Prevotella copri were microbial biomarkers of healthy people. - #Gammaproteobacteria and #Enterobacterales were biomarkers of being “Overweight”.
• [1.21] [#Rheumatoid Arthritis] 
  - IgG and IgA autoantibodies from individuals who are at risk for RA cross-react against gut bacteria in the Lachnospiraceae and #Ruminococcaceae families. - RA > a bacterial strain from the Subdoligranulum genus (#Subdoligranulum didolesgii) that was associated with autoantibody development.
• [1.22] [#Butyrate] 
  - the Lachnospiraceae family of anaerobic bacteria increased during #Fasting. - This family, in the order Clostridiales, promotes butryogenesis in the gut, a process that is associated with healthful metabolic and prolongevity effects.
• [1.23] [#Depression] [#Christensenellaceae, #Coprococcus eutactus] 
  - RuminococcaceaeUCG005 as the most important genus in predicting depressive symptoms. - #Sellimonas, #Eggerthella, #Lachnoclostridium and #Hungatella were more abundant in individuals with higher depressive symptoms. - 12 genera and 1 microbial family associated with depressive symptoms > genera #Sellimonas, #Eggerthella, #Ruminococcaceae (UCG002, UCG003, UCG005), #Lachnoclostridium, #Hungatella, Coprococcus, LachnospiraceaeUCG001, Ruminococcusgauvreauiigroup, #Eubacterium ventriosum, #Subdoligranulum and family #Ruminococcaceae.
• [#Depression] - LachnospiraceaeUCG001, at species level, was found to be associated with anhedonia in mice
• [1.24] [#Ruminococcaceae] 
  - #Resistant starch prebiotic fibers > increase Prevotella and families Lachnospiraceae and Ruminococaceae
• [#Parkinson’s Disease] - PD > increased relative abundance of family Enterobacteriaceae, genera #Akkermansia, #Lactobacillus, #Bifidobacterium. - PD > decreased relative abundance of family Lachnospiraceae, #Faecalibacterium
• [1.25] [#Plastics] 
  - tea bags-treated mice were proved an increase in Lachnospiraceae and a decreased in #Muribaculaceae in gut
• [1.26] 
  - #Fasting > increased microbiome diversity and was specifically associated with upregulation of the #Clostridiales order–derived Lachnospiraceae and #Ruminococcaceae bacterial families. - increased Lachnospiraceae > #Butyrate
• [1.27] 
  - the gut microbiome signatures associated with the markers of cellular senescence and inflammatory factors, known as senescence-associated secretory phenotype (SASP) were evaluated. Findings revealed that #Clostridiales, #Staphylococcus, and Lachnospiraceae positively correlated with all of the cellular senescence and inflammatory markers.
• [1.28] [#Diabetes Type 2] 
  Diabetes : - The gut–brain–beta cell glucagon-like peptide-1 (GLP-1)-dependent axis and the clock genes both control insulin secretion. - GLP-1sensitivity is maximal during the dark feeding period, i.e., the postprandial state. - The abundance of ileum bacteria, particularly #Ruminococcaceae and Lachnospiraceae, oscillated diurnally, with a maximum during the dark period, along with expression patterns of a subset of clock genes. - This diurnal pattern of circadian gene expression and Lachnospiraceae abundance was also observed in two separate mouse models of gut microbiota dysbiosis and of autonomic neuropathy with impaired GLP-1 sensitivity.
• [1.29] [#Behcet’s Disease] 
  - Depleted #Dorea, #Blautia, #Coprococcus, #Erysipelotrichaceae and Lachnospiraceae as well as enriched #Bilophila and #Stenotrophomonas were identified in BU patients.
• [#Clostridium clusters XIVa] - elevated levels of #Anaerotruncus spp., Clostridium XIVa, and Lachnospiraceae in #Parkinson’s Disease patients were associated with dyskinesia symptoms in #Parkinson’s Disease patients, while elevations in #Akkermansia were associated with non-motor impairments in #Parkinson’s Disease patients
• [1.31] [#Amyloid-beta] 
  - In the mice study, the increased abundance of Lachnospiraceae family was associated with reduced deposition of β #Amyloid in brain tissue
• [#Mild Cognitive Impairment] - the abundance of #Butyrate producing bacteria such as Lachnospiraceae family, #Subdoligranulum sp., #Roseburia intestinalis, and #Roseburia hominis were reduced in the gut of MCI participants compared to cognitively healthy controls.
• [1.32] [#Olive] 
  - Lachnospiraceae, known to increase with EVOO consumption, positively correlated with plasma HDL #Cholesterol in humans.
• [1.33] [#Antibiotic Therapy] 
  - Postnatal antibiotic exposure > reduced relative abundance of Lachnospiraceae (for example, #Dialister spp. and #Lachnospira spp.) and #Ruminococcaceae and increased relative abundance of #Veillonella.
• [#Children] - delayed entry into #Daycare is associated with reduced relative abundance of Lachnospiraceae, #Ruminococcaceae and #Prevotella spp. and delayed maturation of the gut microbiome.
• [1.34] [#Hypertension] [#Short Chain Fatty Acid] 
  - normotension group exhibited higher levels of Gram-positive bacteria, such as #Clostridia, #Ruminococcaceae, and Lachnospiraceae, which are mostly SCFA-producing bacteria.
• [1.35] [#High fibre diet, #Nuts] 
  - nut fibers stimulated family Lachnospiraceae- and #Ruminococcaceae-related OTUs.
• [1.36] [#Crohn’s disease] [#Dorea longicatena, #Ruminococcus lactaris] 
  - ileocolonic resection (ICR) in CD patients > amples collected at time of surgery were enriched in #Proteobacteria and harbored high levels of unusual, bacteria such as #Streptococcus mitis, #Undibacterium oligocarboniphilum, #Sphingomonas melonis and #Gemella haemolysans - 6 months after surgery samples had elevated proportions of anaerobic bacteria belonging to Lachnospiraceae (#Clostridium nexile, #Blautia wexlereae, #Dorea longicatena). - Remission was characterized by increased levels of bacteria belonging to #Bacteroides, #Dorea, #Ruminococcus and #Dialister genera, whereas recurrence was associated with increased levels of #Gemmiger formicilis, #Enterococcus durans and #Ruminococcus lactaris.
• [1.37] 
  - especially in #Crohn’s disease, is the decreased abundance of #Firmicutes bacteria belonging to two families that are important functional members of the human gut microbiota─#Ruminococcaceae and Lachnospiraceae─to which most #Butyrate-producing bacteria in the human gut belong.
• [1.38] 
  - Lachnospiraceae is a beneficial #Butyrate-producing bacterium
• [#Parkinson’s Disease] [#Escherichia] - The #Fisetin group gut microbiota exhibited a significantly higher abundance of Lachnospiraceae and a significantly lower abundance of uncultured_bacterium_g_Bacillus and uncultured_bacterium_g_Escherichia-Shigella. - patients with PD exhibited a lower abundance of Lachnospiraceae than healthy control. - the abundance of Lachnospiraceae was reduced by 42.9%, while that of #Bifidobacteriaceae was enriched in patients with PD. - #Fisetin may exert its neuroprotective effect by increasing the abundance of Lachnospiraceae, which alleviates gut inflammation and reduces the production of toxic substances. - intestinal Lachnospiraceae in patients with PD decreased with a concomitant decrease in the SCFA levels. - Lachnospiraceae can promote the aggregation of regulatory T cells in the colon and reduce the immunoglobulin E level, while regulatory T cells can delay the dopaminergic neurodegeneration in PD
• [1.39] [#Cancer, #Melanoma] 
  - An #Immune checkpoint inhibitor (ICI)-favorable response was characterized by an intestinal microbiome rich in bacteria such as #Oscillospira sp., #Clostridia UCG-014, Lachnospiraceae UCG-010 sp., #Prevotella copri, and a decrease in #Sutterella sp., #Lactobacillales, and #Streptococcus sp. - Patients who developed immune-related adverse events (irAEs) had an overall increased microbial diversity and richness, and a stool microbiome depleted in #Agathobacter.
• [#Obesity] [#Collinsella aerofaciens] - subjects with BMI values ≥25 kg/m2 have higher relative abundances of members of the #Collinsella genus (e.g., #Collinsella aerofaciens), and the #Veillonellaceae and Lachnospiraceae families (e.g., genera #Dorea, #Lachnospira, #Coprococcus).
• [#Obesity] - #Coprococcus genus and Lachnospiraceae, were more abundant in subjects with BMI ≥25 kg/m2 and those with greater skeletal muscle mass
• [#High Fat Diet] - (Lachnospiraceae, #Oscillospiraceae, and #Clostridiaceae) produce #Butyrate and thus also likely contribute to the observed increase in #Butyrate-producing bacteria in HFD mice.
• [#High Fat Diet] - HFD microbiota revealed increased abundance of bacteria belonging to Lachnospiraceae, #Oscillospiraceae, and #Clostridiaceae, families which contain pathogenic bacteria
• [1.41] [#Hepatocellular cancer] 
  - hepatocellular carcinoma > #Prevotella was enriched in patients with Progressive Disease. - hepatocellular carcinoma > #Lachnoclostridium, Lachnospiraceae, and #Veillonella were predominant in patients with objective responses.
• [1.42] [#Systemic lupus erythematosus] 
  - #Lactobacillaceae significantly decreased and Lachnospiraceae significantly increased in lupus-prone MRL/lpr mice. - Increased intestinal abundance of #Lactobacillaceae was associated with improvement of lupus symptoms, while increased colonization of Lachnospiraceae was associated with disease progression
• [1.43] 
  - Patients with axial #Spondyloarthritis (SpA), #Acute anterior uveitis (AAU), and #Crohn’s disease > low abundances of Lachnospiraceae taxa relative to controls, most notably #Fusicatenibacter, which was most abundant in controls receiving NSAID monotherapy and implied to partially mediate higher #Serum CRP.
• [1.44] [#Inflamatory bowel disease] [#Faecalibacterium prausnitzii] 
  - Decreased abundance on #Firmicutes bacteria belonging to the #Ruminococcaceae spp., Lachnospiraceae spp, F. prausnitzii and #Roseburia spp. families is a signature of microbial dysbiosis in IBD.
• [1.45] 
  - An abundance of Lachnospiraceae_NK4A136_group and #Prevotella were elevated with #Vitamin B6 deficiency,
• [1.46] [#Diabetes Type 2] 
  - Lachnospiraceae UCG-001 abundance was inversely associated with DNAme in the promoter region of four metabolically relevant genes, including those involved in insulin secretion.
• - greater abundance of some Lachnospiraceae species is associated with #Obesity and altered lipid and #Glucose metabolism, while others, such as Lachnospiraceae NK4A136, have been described as protective against #Obesity. - While some work indicates that a greater abundance of Lachnospiraceae UCG-001 may be associated with #Obesity, other preclinical and human studies suggest this species may be predictive of weight loss among those with overweight/#Obesity
• [1.47] [#Ulcerative Colitis] [#Short Chain Fatty Acid] 
  - UC > depletion of SCFA-producing #Bacteria such as #Prevotella, #Roseburia, Lachnospiraceae, and #Ruminococcaceae.
• [1.48] [#Crohn’s disease] [#Colectomy] 
  - in CD patients > Six months after surgery, ten patients developed recurrence of CD lesions. Samples collected at time of surgery were enriched in #Proteobacteria and harbored high levels of unusual, bacteria such as #Streptococcus mitis, #Undibacterium oligocarboniphilum, #Sphingomonas melonis and #Gemella haemolysans, while 6 months after surgery samples had elevated proportions of anaerobic bacteria belonging to Lachnospiraceae (#Clostridium nexile, #Blautia wexlereae, #Dorea longicatena). Remission was characterized by increased levels of bacteria belonging to Bacteroides, Dorea, Ruminococcus and Dialister genera, whereas recurrence was associated with increased levels of #Gemmiger formicilis, #Enterococcus durans and #Ruminococcus lactaris.
• [1.49] [#Parkinson’s Disease] 
  - #Prevotellaceae, Lachnospiraceae, and #Faecalibacterium were decreased significantly in patients with PD compared to healthy controls, while #Ruminococcaceae, #Bifidobacteriaceae, #Christensenellaceae, and #Verrucomicrobiaceae were enriched in patients with PD
• - #Kefir reduced triglycerides, #Uric acid, and affected the microbiome of animals increasing fecal #Butyrate-producing bacteria (Lachnospiraceae and #Lachnoclostridium).
• [1.51] [#Multiple Sclerosis] 
  - #Children with MS exhibit low levels of Lachnospiraceae and #Ruminococcaceae and significant levels of #Desulfovibrionaceae members
• [1.52] [#Fiber-free diet] 
  - The lack of dietary fiber > reduced abundances of the #Butyrate-producing genera Lachnospiraceaea NK4A136 and #Roseburia. Additionally, #Lactobacillus, which was also reduced in Fibre deprived mice
• [1.53] [#Fever] [#Antibiotic Therapy] 
  - gut microbiome is a key modulator of body temperature variation in both health and critical illness - Lachnospiraceae family was consistently associated with temperature trajectories in hospitalized patients, experimental #Sepsis, and antibiotic-treated mice.
• [1.54] [#Osteoporosis] 
  - higher abundances of Lachnospiraceae NK4A136 group, and #Faecalibacterium were associated with greater tibia cortical vBMD
• [1.55] 
  - the exact relationship between Lachnospiraceae abundance and #Fasting cannot be made clear.
• [1.56] [#Antibiotic Therapy, #Exercise training] 
  - absence of the microbiome in germ-free or antibiotics-treated mice diminishes voluntary and endurance exercise capacity by ∼50%. - this effect of the microbiota was driven by certain taxonomic elements, including members of the Lachnospiraceae family.
• [1.57] [#Exercise training] 
  - Chronic exercisers have a greater abundance of the Lachnospiraceae and #Faecalibacterium prausnitzii, major #Butyrate producers.
• [#Exercise training] - Abundance of Lachnospiraceae (#Roseburia and #Lachnospira) has been positively correlated with VO2max and fecal #Butyrate after 2 weeks of high-intensity interval training.
• [1.58] [#Autism] 
  - significantly higher proportions of #Collinsella, #Coriobacteriaceae UCG-003, #Ruminococcus torques group, #Sarcina, #Slackia, #Solobacterium, #Methanosphera, and Lachnospiraceae NKA3A20-group were found in ASD
• [1.59] [#Phenylacetylglutamine] 
  - circulating PAG levels to different families of gut microbes such as #Coriobacteriaceae, #Mogibacteriaceae, #Bifidobacteriaceae, with genera in the Lachnospiraceae, #Christensenellaceae and #Ruminococcaceae families and with gut microbiome diversity.
• [#Coronary artery disease] [#Phenylacetylglutamine] - three genera in the Lachnospiraceae family that were inversely correlated with PAG, were themselves positively correlated with the FRS. - association between PAG and incident CAD is significant in both individuals with high and with low of FRS.
• [#Liver fibrosis, #Metabolic associated fatty liver disease] - supplementation with Lachnospiraceae and #Ruminococcaceae can protect against obesity, inflammation, intestinal dysbiosis, and hepatic #Fibrosis in MASLD
• - increase in Lachnospiraceae, #Ruminococcaceae, and #Lactobacillus species following #Beta-glucan treatment.
• [1.61] [#Colorectal cancer] 
  - Lachnospiraceae UCG-003 can potentially protect against colon cancer by #Butyrate production
• [#Covid-19] [#Roseomonas mucosa] [#Short Chain Fatty Acid] [#mRNA vaccine] - different bacterial groups from Lachnospiraceae to be associated with either high or low spike IgG levels. - bacterial members belonging to the family Lachnospiraceae are well-known producers of SCFAs in colon mucosa-associated microbiota. - #Lachnospiracea FSC020, which shows a positive association with spike IgG levels > a potential positive association with the production of #Acetate and propionat
• [#Hepatocellular cancer] - Lachnospiraceae UCG-008 to be negatively associated with age and saturated fatty acid intake and has decreased abundance in conditions like liver cirrhosis and hepatocellular carcinoma.
• [1.62] [#Depression] [#D-ribose] 
  - RIB-fed mice were characterized by 22 differential bacteria taxa on the Genera level, especially #Akkermansia, #Turicibacter, and Lachnospiraceae_UCG-006
• [1.63] [#Collagen-induced arthritis , #Rheumatoid Arthritis, #Spondyloarthritis] [#Lachnospiraceae bacterium] 
  - in CIA (such as Lachnospiraciae and Lactobacillaeae), RA (Lachnospiraceae bacterium, #Lactobacillus spp., #Faecalibacterium), and SpA (#Ruminococcaceae, #Rikenellaceae, #Porphyromonadaceae, #Bacteroidaceae, Lachnospiraceae) are either predicted or known to produce #Indole
• [1.64] [#Diabetes Type 2] 
  - Lachnospiraceae microbiome was associated with an excess of faecal monosaccharides. - the increased presence of Lachnospiraceae (#Dorea, #Blautia) in the gut microbiota was positively correlated with IR.
• [1.65] [#Chronic fatigue syndrome] [#Flagellin] 
  - severe ME/CFS have excessive antibodies against flagellins, especially as a pathogen-associated molecular pattern (PAMP) from lachnospiraceae, compared to the healthy controls
• [1.66] [#Lipopolysaccharide] [#Sleep Deprivation] 
  - SF (Sleep Frgamentation) modifies the gut microbiome, leading to an elevation in the Lachnospiraceae family and a decline in the #Lactobacillaceae family. - The former is associated with intestinal inflammation, whereas the latter acts as a protective barrier. - SF lowers antioxidant capacity and depletes the number of goblet cells and colonocyte proliferation.36 It also intensifies LPS-binding protein circulation levels and stimulates an enhanced inflammatory response.
• [1.67] [#Gout, #Hyperuricemia] 
  - #Escherichia-#Shigella exhibited a positive association with SU levels, while Lachnospiraceae NC2004 group and Family XIII AD3011 group were associated with a reduced HUA risk.
• [1.68] 
  - #Victivallaceae and Lachnospiraceae NK4A136 group create a competitive advantage over harmful bacteria, effectively inhibiting their growth. - #Victivallaceae and Lachnospiraceae (NK4A136 group) actively promote normal immune function.
• - Lachnospiraceae NK4A136 group can synthesize #Vitamin K, specific B vitamins such as #Folic acid and #Vitamin B12
• - taxa with potential associations to the risk of #Psoriasis include #Mollicutes, #Victivallaceae, #Eubacterium coprostanoligenes, #Eubacterium fissicatena, #Holdemania, Lachnospiraceae NK4A136, #Lactococcus, #Tenericutes.
• - negative correlation between #Victivallaceae and Lachnospiraceae NK4A136 group and the risk of #Psoriasis.
• [1.69] [#Cushing’s disease] 
  - #Collinsella, a genus form of the #Actinobacteria phylum was present in CD patients only, whereas #Sutterella, a genus from #Proteobacteria phylum, was scarcely detectable/undetectable in CD patients as well as #Lachnospira, a genus of the Lachnospiraceae family of the #Firmicutes phylum.
• [#Organophosphorus] - Most abundance changes at the genus level associated with high ambient OP exposure belong to the Lachnospiraceae (seven genera were increased and two were decreased) and #Ruminococcaceae (3 genera were increased and 2 were decreased) families in the #Clostridia class.

References Notes