Firmicutes ⇒ Clostridia {10000264}

Shared Reference Notes

• [1.1] 
  - Clostridia bacteria gene clusters are able to produce #Fatty acid amides (FAAs), which are signaling molecules produced by humans. - FAAs are known to have diverse physiological effects — ranging from immunoregulation to sensing pain to wound healing. - Bacterial enzymes from Clostridia bacteria used diet-derived substrates to produce FAAs that interact with human receptors.
• [1.2] [#P-glycoprotein] 
  - Genera within the Clostridia and Bacilli classes are necessary and sufficient for P-gp induction in the intestinal epithelium in mouse models.
• [1.3] [#Exercise training] 
  - Single bout of exercise > upregulated metabolic pathways of skeletal muscle substrate utilization and carbohydrate metabolites in serum > increased fecal #Ammonia and amino acid metabolites > increased the abundance of Clostridia
• [1.4] [#Leukemia] [#Antibiotic Therapy] 
  - Lukemia >Exposure to antibiotics, in particular piperacillin/tazobactam, meropenem and imipenem/cilastatin (P-I-M), in the 4 weeks before therapy was associated with worse survival and increased neurotoxicity. - Lukemia > species within the class Clostridia that were associated with day 100 complete response to Anti-CD19 chimeric antigen receptor (CAR) T cell therapy.
• [1.5] [#Autism] 
  - up-regulation was found for some metaproteins associated with Clostridia and with carbohydrate metabolism (glyceraldehyde-3-phosphate and glutamate dehydrogenases), while down-regulation was observed for others associated with #Bacteroidia
• [1.6] [#Food Allergy] 
  - #Butyrate-producing Clostridia, are depleted in food-allergic individuals. - #Butyrate-containing micelles, used in combination, restore a barrier-protective response in mice treated with either dextran sodium sulfate or antibiotics. Treatment with the micelles protects peanut-allergic mice from an anaphylactic reaction to peanut challenge and rescues their dysbiosis by increasing the abundance of #Clostridium cluster XIVa.
• [1.7] 
  - #Bacteroides fragilis and several Clostridia species have been reported to cause an anti-inflammatory response

References Notes