Disease ⇒ Fibrosis {40000517} Record Keys Type:Disease Parent:[ ] Definition:Fibrosis Details Initialisation date:2022-01-24 Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Lactobacillus paracasei] - The fibrosis-triggering microbial populations in the cecum as mucolytic bacteria : the species #Mucispirillum schaedleri, the genus #Ruminococcus, and the genus #Anaeroplasma, and in the ileum, such as the genera #Streptococcus and Lactobacillus. - Members of the genera #Oscillospira and #Coprococcus in the cecum, as well as #Faecalibacterium prausnitzii and members of the genus #Bacteroides in the ileum > negatively correlated with fibrosis. [1.2] [1.3] [#CVD] [#Exercise training, #Western-style diet] - voluntary exercise curbs #TMAO elevation and decreases myocardial inflammation and fibrosis, leading to the prevention of cardiac dysfunction in western diet-induced #Obesity [1.4] - #IL-17A has been found to be associated with neurological sequelae and pulmonary fibrosis in post-#Covid-19 patients - Elevated blood levels of hydroxyproline have been proposed as a biomarker for diseases characterized by fibrosis, indicating an increased demand for #Proline in collagen synthesis. [1.5] - #Sulforaphane is a naturally occurring, potent antioxidant, found in Brassicaceae plants such as #Broccoli, and is being considered for use in the treatment of fibrosis, #Cancer and preeclampsia [1.6] [#End-stage renal disease] - #Nitrate treatment boosted the #Nitrate-nitrite-NO pathway, which ameliorated UUO-induced renal dysfunction and fibrosis in mice, represented by improved glomerular filtration and morphological structure and decreased renal collagen deposition, pro-fibrotic marker expression, and inflammation. [1.7] [#Liver fibrosis, #Metabolic associated fatty liver disease] - supplementation with #Lachnospiraceae and #Ruminococcaceae can protect against obesity, inflammation, intestinal dysbiosis, and hepatic fibrosis in MASLD [1.8] [#Metabolic associated fatty liver disease] [#Lactobacillus bulgaricus, #Lactobacillus paracasei, #Lactobacillus plantarum] - Randomized controlled trials in NAFLD patients revealed that administration of polymicrobial probiotics (containing #Bifidobacteria, #Lactobacillus acidophilus, L. bulgaricus, L. paracasei, L. plantarum, and #Streptococcus thermophilus) significantly reduced the fatty liver phenotype, inflammation, and fibrosis. [1.9] [#Chronic kidney disease] - #TMAO causes kidney injury and tubulointerstitial fibrosis. - Higher #TMAO levels associated with higher risk of incident CKD and greater annualized eGFR decline, and with monotonic dose-response relationships. References Notes[ ]