Disease ⇒ Fibrosis {40000517}

Shared Reference Notes

• [1.1] [#Lactobacillus paracasei] 
  - The fibrosis-triggering microbial populations in the cecum as mucolytic bacteria : the species #Mucispirillum schaedleri, the genus #Ruminococcus, and the genus #Anaeroplasma, and in the ileum, such as the genera #Streptococcus and Lactobacillus.
• - Members of the genera #Oscillospira and #Coprococcus in the cecum, as well as #Faecalibacterium prausnitzii and members of the genus #Bacteroides in the ileum > negatively correlated with fibrosis.
• [1.2] 
• [1.3] [#CVD] [#Exercise training, #Western-style diet] 
  - voluntary exercise curbs #TMAO elevation and decreases myocardial inflammation and fibrosis, leading to the prevention of cardiac dysfunction in western diet-induced #Obesity
• [1.4] 
  - #IL-17A has been found to be associated with neurological sequelae and pulmonary fibrosis in post-#Covid-19 patients
• - Elevated blood levels of hydroxyproline have been proposed as a biomarker for diseases characterized by fibrosis, indicating an increased demand for #Proline in collagen synthesis.
• [1.5] 
  - #Sulforaphane is a naturally occurring, potent antioxidant, found in Brassicaceae plants such as #Broccoli, and is being considered for use in the treatment of fibrosis, #Cancer and preeclampsia
• [1.6] [#Chronic lung disease] 
  - #Butyrate acid administration as a means of restoration of GI-microbiota has reduced the degree of lung fibrosis in animal models
• [1.7] [#Non alcoholic steatohepatitis] [#Lipopolysaccharide] 
  - LPS-mediated inflammatory signaling has been shown to accelerate the progression of NASH with liver inflammation and fibrosis.
• [1.8] [#End-stage renal disease] 
  - #Nitrate treatment boosted the #Nitrate-nitrite-NO pathway, which ameliorated UUO-induced renal dysfunction and fibrosis in mice, represented by improved glomerular filtration and morphological structure and decreased renal collagen deposition, pro-fibrotic marker expression, and inflammation.

References Notes