Enterobacteriales ⇒ Enterobacteriaceae {10000123}

Shared Reference Notes

• [1.1] 
  - Members of the Enterobacteriaceae family have a proinflammatory #Lipopolysaccharide (LPS) in the outer membrane and can exacerbate inflammation. A high relative abundance of Enterobacteriaceae is reported in inflammatory bowel diseases, in metabolic disorders like type 2 diabetes, and in immune diseases like cancers.
• [1.2] [#Biliary tract cancer] 
  - The predominant dysbiotic bacteria in both #Chronic cholecystitis and gallbladder #Cancer were those belonging to the Enterobacteriaceae family. #Klebsiella increased significantly in the order of normal, #Chronic cholecystitis, and gallbladder #Cancer.
• [1.3] [#Crohn’s disease] [#Condition of chronic stress] 
  - Stress-exposed mice > develop ileal dysbiosis, dominated by the expansion of Enterobacteriaceae. - Stress-induced glucocorticoids promote > apoptosis of CD45+CD90+ cells that normally produce #IL-22, a cytokine that is essential for the maintenance of ileal mucosal barrier integrity. - Blockade of glucocorticoid signaling or administration of recombinant #IL-22 > restores mucosal immunity, prevents ileal dysbiosis.
• [1.4] [#Depression] [#Lactobacillaceae, #Limosilactobacillus (Lactobacillus) reuteri] [#Probiotic (Bifidobacter and Lactobacilus)] 
  - Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > reduction in depressive symptoms at four and eight weeks of treatment, and #Anxiety symptoms at four weeks. > improvement in #Sleep quality. - Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > decrease in serum interleukin-6 levels. - Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > increased #Bifidobacteriaceae and Lactobacillacea, whereas it decreased Enterobacteriaceae in the gut microbiota composition.
• [1.5] 
  - #Chronic fatigue syndrome > lower anti-inflammatory species carriage and higher levels of pro-inflammatory bacterial species such as Enterobacteriaceae were found in a 16S rRNA stool sample analysis. - Higher levels of Enterococcus spp, Streptococcus spp, lower levels of the beneficial Bifidobacteria and decreased anti-inflammatory Firmicutes have been detected.
• [1.6] [#Infectious diarrhea] 
  - The gut microbiome undergoes a dramatic taxonomic change upon diarrhea’s onset, favoring the proliferation of fast-growing facultative anaerobes. Proteobacteria (mostly Enterobacteriaceae/E. coli) and Streptococcus (mainly #Streptococcus salivarius and #Streptococcus gallolyticus) are most significantly enriched during this early phase
• [1.7] [#Parkinson’s Disease] 
  - a few putative pathobionts of the family Enterobacteriaceae, #Enterococcaceae, which are assumed to possibly reduce the production of SCFA, produce endotoxins and neurotoxins that promote intestinal inflammation, are enriched in PD
• [1.8] [#Diabetes Type 1] 
  - Particular bacterial protein #BefA, which is found in rodent and human gut microbes, can help restore insulin production - #BefA-related sequences uncovered homologs in a handful of bacteria of the Enterobacteriaceae family commonly found in healthy mammalian microbiomes after birth, when β cells normally undergo substantial expansion. - #BefA could induce proliferation directly in primary islet cultures from both hosts (Zebrafish and mouse). - The #BefA-containing Enterobacteriaceae bacteria are abundant colonizers of the healthy infant gut during peak neonatal β cell expansion.
• [1.9] [#Parkinson’s Disease] 
  - positive correlation between Enterobacteriaceae abundance and the motor phenotype, particularly postural instability and gait alterations
• [#Antibiotic Therapy, #Infants treated with antibiotic] - #Infants treated with antibiotics tend to have lower bacterial diversity as well as an increase of Enterobacteriaceae and #Enterococcus
• [1.11] 
  - alkaline environment of the distant part of the small intestine promotes growth of Enterobacteriacea.
• [1.12] [#Bipolar disorder] 
  - Levels of #Faecalibacterium prausnitzii, #Bacteroides–#Prevotella group, #Atopobium Cluster, #Enterobacter spp. and #Clostridium cluster IV were higher in BD patients than healthy subjects along with a reduced #Bifidobacteria to Enterobacteriaceae ratio, having these changes a possible impact on brain function in these patients.
• [1.13] 
  -#Clostridia and Enterobacteriaceae could also be involved in #Phosphatidylcholine metabolism, which decreases the abundance of #Bifidobacterium spp. due to competition for the substrate.
• [1.14] [#Short Chain Fatty Acid] [#Aging] 
  - Age-related intestinal dysbiosis is generally characterized by a decrease in short-chain fatty acid producers, for example, #Clostridiales, and #Bifidobacterium, and enrichment of pro-inflammatory #Proteobacteria including the opportunistic Enterobacteriaceae.
• [1.15] 
  - in severe #Depression > reduced #Bifidobacteriaceae and #Prevotellaceae with elevated Enterobacteriaceae and #Ruminococcaceae.
• - the level of #Quercetin consumption was negatively correlated with the abundance of #Sutterellaceae and #Oscillospiraceae spp. and positively correlated with the families #Fusobacteriaceae and Enterobacteriaceae
• [1.16] [#Natural Small intestine Microbiome] [#Proton pump inhibitors] 
  - PPI > induce SI duodenal microbiota dysbiosis, characterized by an increase in #Akkermansia muciniphila and #Porphyromonas endodontalis and a decrease in #Enterococcaceae, #Coprococcus, Enterobacteriaceae, and #Synergistes species
• [#Natural Small intestine Microbiome] [#Smoking] - In the SI lumen, the abundance of #Prevotellaceae, #Neisseriaceae, and #Porphyromonadaceae is reduced in smokers, whereas Enterobacteriaceae and #Lactobacillaceae abundances are increased.
• [1.17] [#Escherichia coli, #Helicobacter pylori, #Shigella flexneri] 
  - Notable genera in the #Proteobacteria are #Escherichia, #Salmonella, #Shigella, #Desulfovibrio, and #Helicobacter. Included in the phyla is the Enterobacteriaceae family, which contains several enteropathogenic bacteria, including #Shigella flexneri, #Salmonella typhi, and #Escherichia coli. Other enteric pathogens in this phylum are #Vibrio cholerae and #Helicobacter pylori.
• [#Irritable bowel syndrome] - IBS patients have increased levels of the bacterial families Enterobacteriaceae, #Lactobacillaceae, and #Bacteroidales, whereas #Bifidobacterium, #Faecalibacterium, and #Clostridiales were decreased compared with healthy controls.
• [1.18] [#Parkinson’s Disease] 
  - #Hydrogen sulfide produced by several Enterobacteriaceae and #Desulfovibrionaceae can enter host cells, cause the release of cytochrome c protein from mitochondria into the cytoplasm, mediate the accumulation of cytosolic iron and #Reactive Oxygen Species, thus boosting α-synuclein synthesis
• [1.19] 
  - abundance of Enterobacteriaceae and #Alistipes was increased, and #Faecalibacterium abundance was decreased in patients with #Major depressive disorder
• [#Clostridioides difficile] [#Para-cresol] - p-Cresol is an aromatic derivative of #Tyrosine produced as a catabolite by many members of the gut microbiota, including some #Bifidobacteriaceae, Enterobacteriaceae, #Clostridiaceae, #Lactobacillaceae, #Coriobacteriaceae, and #Bacteroidaceae. - #Clostridia difficile has displayed a particular growth advantage on p-cresol and people with #Autism spectrum disorders often have a gut microbiome that is enriched in #Clostridia.
• [1.21] 
  - The changes in Enterobacteriaceae induced by #Antibiotic Therapy are transient.
• [1.22] [#Systemic lupus erythematosus] 
  - increased abundance in Enterobacteriaceae and #Enterococcaceae and decreased abundance in #Ruminococcaceae in the gut microbiota of patients with SLE.
• [1.23] [#Non-nutritive Sweeteners, #Sweeteners] 
  - the #Fasting #Glucose concentrations and the abundances of Enterobacteriaceae and #Clostridium leptum were increased in diet-induced #Obesity models treated with aspartame for eight weeks
• [1.24] [#Oral squamous cell carcinoma] 
  - Oral cancer and epithelial precursor lesions are also linked with bacteria from genera #Fusobacterium, #Veillonella, #Actinomyces, #Clostridium, #Haemophilus, and Enterobacteriaceae
• [1.25] 
  - #Curli is a bacterial protein produced by Enterobacteriaceae.
• [#Parkinson’s Disease] [#Alpha-synuclein] - Enterobacteriaceae is increased in patients with PD and is associated with disease severity. - Its role as an αSyn cross-seeding agent, in the promotion of αSyn aggregation and worsening of motor symptoms, was documented in different models, such as C. elegans, Fisher rats, and another line of αSyn-overexpressing mice.
• [#Parkinson’s Disease] - Enhanced #Curli exposure in PD could be the result of its secretion by Enterobacteriaceae for biofilm formation covering the intestinal mucosa.
• [1.26] [#Clostridium asparagiforme, #Clostridium citroniae, #Clostridium hathewayi, #Clostridium sporogenes] [#TMA, #TMAO] 
  - #Clostridium sp (C asparagiforme, C citroniae, C hathewayi, and C sporogenes), #Desulfovibrio, and Enterobacteriaceae (#Escherichia coli and #Acinetobacter sp), can respond to a diet rich in #Choline, an essential nutrient for omnivores, and convert it to trimethylamine, which is then metabolised in the liver to trimethylamine N-oxide, a microbiome derived proatherogenic metabolite.
• [1.27] [#Intrahepatic Cholangiocarcinoma] 
  - The enrichment of specific enteric bacteria (#Bifidobacteriaceae, Enterobacteriaceae, and #Enterococcaceae) correlated with parasite-associated cholangiocarcinoma
• [1.28] 
  - Specific bacterial genera, including #Catenibacterium, #Prevotellaceae, and Enterobacteriaceae, enriched in PLWH > were strongly associated with accelerated biological #Aging. - These bacterial taxa can catabolize #Tryptophan and were correlated with elevated levels of the metabolic byproducts of #Tryptophan catabolism. Increased #Tryptophan catabolism leads to an accumulation of toxic metabolic byproducts such as #kynurenine and #Quinolinic acid. - These byproducts have been linked with adverse outcomes in chronic #HIV infection
• [1.29] [#Multiple Sclerosis] 
  - the Enterobacteriaceae family (including #Escherichia, #Shigella, #Enterobacter and others) exhibited a large increase in abundance in the MS group
• - #Copper beads > Enterobacteriaceae (EB) increased, while #Lactic acid bacteria (LAB) decreased during the treatment period. - When beads were removed from the feed, EB and LAB concentrations returned to baseline. - #Copper bead supplementation > increase in #Firmicutes, #Euryarchaeota, and #Acidobacteriota, while at the genus level, an increase in #Methanosphaera and #Pseudomonas was observed.

References Notes