Disease ⇒ Fibromyalgia {40000178} Record Keys Type:Disease Parent:[ ] Definition:Fibromyalgia Details Initialisation date:2020-09-06 Other Terms:Complex Regional Pain Syndrome, CRPS, Myofascial Pain Syndrome LinksMerck Manual Meta Information MedDra ID:10048439 MedDra Level:pt ICD:[ ] Category:Musculoskeletal, Rheumatology Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - Chronic fatigue syndrome (CFS) shares some symptomatic features with FM. [1.2] [1.3] [#α-muricholic acid] - Alterations in the relative abundance of several bacterial species known to metabolize bile acids were observed in women with fibromyalgia, accompanied by significant alterations in the serum concentration of #Secondary bile acids, including a marked depletion of α-muricholic acid. - Serum α-muricholic acid was highly correlated with symptom severity, including pain intensity and fatigue. [1.4] [#Chronic Musculoskeletal Pain, #Vitamin D deficiency, #Vitamin D deficiency-mediated chronic pain] - 25OHD supplementation results in pain reduction. Our results suggest a possible role of #Vitamin D supplementation in alleviating the pain associated with FMS and CMP, especially in #Vitamin D-deficient individuals. [1.5] [#Chronic fatigue syndrome, #Irritable bowel syndrome] - ME/CFS is a multifactorial condition that is also often associated with comorbid conditions including, but not limited to, IBS and fibromyalgia.References Notes[ ]
