Disease ⇒ Colon adenomas {40000235} Record Keys Type:Disease Parent:[ ] Definition:Colon adenomas Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:10048832 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Colorectal cancer] [#Deoxycholic acid, #Secondary bile acids, #Ursodeoxycholic acid] - UDCA has microbiome-changing and DCA‐lowering prpperties. - treatment with UDCA, decreased recurrence of adenomas with high-grade dysplasia. - DCA also stimulates the uptake of polyamines in CRC cells, which also have tumorigenic effects. [1.2] [#Colon polyps] [#Fusobacterium nucleatum] - F. nucleatum modifies colonic Th17 cell frequency and IL-17 expression recombinant free fatty acid receptor 2 (FFAR2)-dependent. - it positively correlated with the expression of Wnt-β-catenin (activated by FadA─E-cadherin) and REG Iα signaling, both of which effectively promotes the proliferation of sessile serrated adenoma/polyp [1.3] [#Colorectal cancer] [#Plant-based diet] - #Flavonifractor plautii and #Bacteroides stercoris transmit the protective or carcinogenic effects of these factors to early carcinogenesis. - #Flavonifractor plautii and #Bacteroides stercoris, for example, were more abundant in people with tubular adenomas than in those with serrated adenomas or in controls. - Both microbes were also less abundant in people with an increased vegetable intake or those who took #Aspirin. [#Short Chain Fatty Acid] - Microbial species that were abundant in people with serrated adenomas included short-chain fatty-acid-producing microbes such as #Ruminococcus lactaris, #Eubacterium ventriosum, #Odoribacter splanchnicus, #Anaerostipes hadrus and #Alistipes shahii. - serrated adenomas tend to associate with multiple microbial antioxidant defense systems. - #Flavonifractor plautii, #Bilophila wadsworthia, #Bacteroides stercoris, #Clostridium asparagiforme, #Clostridium bolteae CAG 59 and #Roseburia intestinalis were more common in people with tubular adenomas. - Tubular adenomas, instead, were linked to a reduction in a process called methanogenesis [#Flavonoid] - #Flavonifractor plautii appears to be linked to the degradation of beneficial anticarcinogenic flavonoids. - Tubular adenomas associate with a decrease in enzymes that metabolize methane - Serrated adenomas exhibit increased NAD, bile acid, and #Sulfate metabolic potential [1.4] [#Colorectal cancer] - The abundance of fecal #Veillonella parvula (V. parvula) decreased significantly after #Berberine administration and increased through the development from CRA to CRC. [1.5] [#Colon polyps] [#Christensenellaceae, #Oscillospiraceae] [#α-glucosidase] - intetinal adenoma > higher abundance of Christensenellaceae_R-7 group and Oscillospiraceae_UCG-002 were found in fecal samples displaying low α-glucosidase activity References Notes[ ]
