Glycans {90000248}

Shared Reference Notes

• [1.1] [#Sialic acid] 
• [1.2] [#Covid-19] 
• [1.3] 
  - #Bacteroides thetaiotaomicron, #Akkermansia muciniphila, Ruminoccous gnavus, #Bacteroides fragilis, and #Bifidobacterium bifidium are predominant bacteria within the mucus layer that utilize glycans as their energy source by glycosidase, sulphatase, and sialidase enzymes
• [1.4] [#Bacteroides thetaiotaomicron] 
  - Mouse models have shown that B. thetaiotaomicron, which normally degrades glycans from plant-based foods, consumes host-derived mucin when diet-derived glycans are not available in sufficient quantitites.
• [1.5] [#Parkinson’s Disease] [#Fiber-free diet, #Low fibre Diet] 
  - The lack of dietary fiber makes specialized taxa, which are equipped with glycan-degrading enzymes, such as #Akkermansia spp. or the Bacteriodetes genera #Alistipes spp. and #Bacteroides spp.,65 switch to host glycans as energy resource, promoting mucus erosion and pathogens susceptibility.
• [1.6] [#Mucin glycans, #Polysaccharide] 
  - #Bacteroides thetaiotaomicron can switch from digesting dietary glycans to mucin glycans in the absence of dietary carbohydrates and plant polysaccharides (dietary fiber), enhancing mucosal barrier function and limiting pathogen invasion.
• [1.7] [#Oral squamous cell carcinoma] 
  - #Pancreatic Cancer > the #Mannose-binding #Lectin, which binds specifically to the glycans on the fungal wall, was activated mainly by the #Malassezia genus, showing potential for tumor formation. - the presence of #Malassezia sp. in OSCC is associated with a favorable prognosis
• [1.8] [#Rheumatoid Arthritis] 
  - In RA > each patient harbors a unique and diverse ACPA IgG1 repertoire dominated by only a few antibody clones. - In contrast to the total plasma IgG1 antibody repertoire, the ACPA IgG1 sub-repertoire is characterised by an expansion of antibodies that harbor one, two or even more Fab glycans.

References Notes