Fructose {90000187}

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Meta Information

Structural Type:
Functional Type:
Energy Source
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Shared Reference Notes

  • [1.1
    - Maternal exposure to fructose > reduces the abundance of #Erysipelatoclostridium in the infant gut microbiome.
  • - Fructose > adversely affects intestinal permeability > disrupts the maternal microbiome > altered offspring gut development. - Fructose > inhibit the growth of harmful flora and promote the growth of beneficial and neutral flora. ??
  • [1.2] [#Diabetes Type 2] [#Alistipes indistinctus
    - Postprandial blood #Glucose levels were particularly reduced in mice administered with A. indistinctus, #Alistipes finegoldii and #Bacteroides thetaiotaomicron that were fed a high-fat diet. - Insulin tolerance tests also revealed that these strains ameliorated IR, most prominently by A. indistinctus administration. - A. indistinctus administration ameliorated body mass gain, ectopic triglyceride accumulation in the liver and #Glucose intolerance - Serum levels of HDL-C, adiponectin and, to a lesser extent, triglycerides, were also improved in mice that were treated with A. indistinctus. - carbohydrate oxidation was significantly reduced in mice that were treated with A. indistinctus, implying that carbohydrate use is limited. - A. indistinctus administration substantially altered caecal metabolites, characterized by a reduction in several carbohydrates including fructose, a lipogenic monosaccharide. - Fructose was similarly reduced in the serum - The AUC of insulin tolerance test was positively correlated with the caecal monosaccharides fructose, #Glucose and #Mannose
  • [#Diabetes Type 2] - Fructose is a widely recognized risk factor for inflammation and Insulin Resistance due to its role in lipid accumulation
  • [1.3] [#Carbohydrate diet
    - On a fructose-rich diet, mice lost beneficial bacteria such as #Prevotella, #Muribaculum, and #Bifidobacterium - These fructose-rich diet mice also showed an enrichment of #Desulfovibrio, #Collinsella, #Olsenella, and #Bacteroides as well as increased frequency of immune cells with pro-inflammatory characteristics
  • [1.4] [#Lactobacillus rhamnosus
    - #Allobaculum was highly abundant in the control group as compared to the fructose group, and it tended to be more abundant in the L. rhamnosus M9 group.
  • [#Bifidobacterium animalis lactis, #Lactobacillus rhamnosus] - #Alloprevotella, increased its abundance in the high-fructose treatment but decreased in both the treatment with B. lactis M8 and L. rhamnosus M9.
  • [#Hypertension] [#Lactobacillus rhamnosus] - #Coprobacillus and #Butyricimonas, were both more abundant in the L. rhamnosus M9 group as compared to the fructose group, which suggests their roles in BP regulation.
  • [1.5] [#Sugar
    - feeding dietary simple sugars like #Glucose and fructose would enhance the abundance of #Akkermansia.
  • [#Depression, #Schizophrenia] [#Sugar] - Dietary sugars, like fructose and #Glucose, are associated with psychosis-related higher brain dysfunction

References Notes

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