Disease ⇒ Eosinophilic chronic rhinosinusitis {40000611} Record Keys Type:Disease Parent:[ ] Definition:Eosinophilic chronic rhinosinusitis Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - nasal dysbiosis in eCRSwNP was defined by increased relative abundances of #Sphingomonas, #Moraxellaceae, #Bacteroides, #Bifidobacterium, #Ruminococcus, and #Faecalibacterium, as well as by decreased abundances of #Ralstonia, #Propionibacterium, and Propionibacter. - #Sphingomonas was more abundant in patients with eCRSwNP than in HCs. - #Sphingomonas species have been associated with increased airway hyperresponsiveness to methacholine. - #Glycolipid antigens from #Sphingomonas species are believed to induce airway hyperresponsiveness in mice through activation of invariant natural killer T cells in an IL-33–dependent manner. - #Sphingomonas abundance was correlated with high absolute tissue eosinophil counts in patients with eCRSwNP.References Notes[ ]
