Veillonella ⇒ Veillonella parvula {10000854}

Shared Reference Notes

• [1.1] [#Multiple Sclerosis] 
  - Orally administered EDP1867, a gamma-irradiated strain of Veillonella parvula, rapidly transits through the murine gut without colonization or alteration of the background microbiome flora. - In murine models of inflammatory disease including delayed-type hypersensitivity (DTH), #Atopic Dermatitis, #Psoriasis, and experimental autoimmune encephalomyelitis (EAE), treatment with EDP1867 resulted in significant reduction in inflammation and immunopathology.
• [1.2] 
  - the tested consortium was composed of four butyrate producers (#Faecalibacterium prausnitzii, #Butyricicoccus pullicaecorum, #Roseburia inulinivorans, and #Anaerostipes caccae) and five propionate producers (#Roseburia inulinivorans, #Akkermansia muciniphila, #Bacteroides vulgatus, Veillonella parvula, and #Blautia obeum)
• [1.3] [#Alzheimer’s disease] 
  - The relative abundance of Veillonella parvula significantly increased in oral microbiomes from AD patients. - The correlation analysis revealed that V. parvula was associated with AD in both saliva and GCF.
• [1.4] 
  - v. parvula is an anaerobic commensal and opportunistic pathogen that plays a crucial role in bacteria adhesion and biofilm formation for oral and gut microbiomes.
• [1.5] [#Sjögren syndrome ] 
  - in SS > The most abundant significantly mutative taxonomy (OTU001) was Veillonella parvula.
• [#Sjögren syndrome ] - Elevated dysbiosis of V. parvula can initiate the progression of SS. - V. parvula, as an immunomodulatory commensal bacterium, may serve as a unique microbial biomarker for SS.
• [1.6] [#Inflamatory bowel disease] 
  - Veillonella parvula, an asaccharolytic, anaerobic, oral microbe that derives energy from organic acids, increases in abundance in the intestine of patients with inflammatory bowel disease.
• - #Nitrate, a signature metabolite of inflammation, allows V. parvula to transition from fermentation to anaerobic respiration. - #Nitrate respiration was fundamental for ectopic colonization in a mouse model of colitis
• [1.7] [#Natural oral microbiomes, #Normal Vaginal condition] 
  - Veillonella parvula is a biofilm-forming commensal found in the lungs, vagina, mouth, and gastro-intestinal tract of humans
• [1.8] 
  - V. parvula plays a protective and helpful role in the early development of a child’s immune system. - the presence of V. parvula was negatively correlated with #Asthma and #Bronchiolitis
• [#Human breast milk, #Infants] - #sIgA content in human milk at 42 days was positively correlated with V. parvula. - #sIgA > regulate microbial colonization and the infant immune response
• [1.9] [#Juvenile idiopathic arthritis] 
  - ABIS JIA had higher abundance of #Acidaminococcales, #Prevotella 9, and Veillonella parvula and lower abundance of #Coprococcus, #Subdoligranulum, #Phascolarctobacterium, #Dialister spp., #Bifidobacterium breve, #Fusicatenibacter saccharivorans, #Roseburia intestinalis, and #Akkermansia muciniphila
• [#Juvenile idiopathic arthritis] [#Human breast milk] - taxa associated with ABIS JIA had a significant association with shorter durations of breastfeeding, including #Acidaminococcales, #Prevotella 9, #Parabacteroides distasonis, and several ASVs belonging to #Bacteroides, Veillonella parvula, #Turicibacter sanguinis, #Eggerthella lenta, and P. distasonis.
• [#Colon adenomas, #Colorectal cancer] - The abundance of fecal Veillonella parvula (V. parvula) decreased significantly after #Berberine administration and increased through the development from CRA to CRC.
• [#Colorectal cancer] - Patients with CRC with a higher V. parvula abundance had worse tumor staging and a higher lymph node metastasis rate.
• - Animal experiments revealed that V. parvula promoted colorectal carcinogenesis and increased B lymphocyte Stimulator levels, while #Berberine reversed this effect.

References Notes