Low fibre Diet {51111193} Record Keys Definition:Low fibre Diet Queue:[ ] Details Initialisation date:2021-05-02 Specification: [ ] Meta Information Type:Diet Host:[ ] Zone:[ ] Notes: [ ]Shared Reference Notes [1.1] - #Butyrate-producing bacteria, like those belonging to Bacteroidetes and Firmicutes phylum, exert their anti-inflammatory activity metabolizing dietary fibers: A low-fiber diet leads to reduced production of #Butyrate, which acts as a negative regulator of pro-inflammatory pathways and enhances the intestinal barrier function. - When Fibre is scarce, intestinal bacteria use the intestinal mucus as a nutrient, which leads to inflammation through close contact between bacteria and the epithelial layer. [1.2] [#Short Chain Fatty Acid] [#Maternal consumption of dietary fibre] - a low-fibre diet during #Pregnancy and lactation leads to reduced SCFA levels and impaired thymic Treg cell differentiation in the offspring [1.3] [#Diabetes Type 2] - Enriched #Collinsella was widely reported in low-fiber diets and metabolic diseases (e.g., type 2 diabetes) [1.4] - in the absence of dietary fibers, some bacteria utilize host glycans, such as, the O-glycans decorating the MUC2 mucin, the main component of colonic mucus. [1.5] [#Fiber-free diet] - the lowest levels of tight junction proteins #ZO-1 and #Occludin in TG mice challenged by fiber deprivation and #Curli. [#Fiber-free diet] - Longer-term lack of dietary fiber triggers a compensatory mechanism, increasing mucin production, and re-establishing at least the inner mucus thickness. [#Parkinson’s Disease] [#Fiber-free diet] - The lack of dietary fiber makes specialized taxa, which are equipped with glycan-degrading enzymes, such as #Akkermansia spp. or the Bacteriodetes genera #Alistipes spp. and #Bacteroides spp.,65 switch to host #Glycans as energy resource, promoting mucus erosion and pathogens susceptibility. [1.6] [#Akkermansia muciniphila] - In the absence of A. muciniphila, the relative abundances of the three other mucin-degrading bacteria, #Bacteroides thetaiotaomicron, #Bacteroides caccae and #Barnesiella intestinihominis, increased in either both dietary groups or in Fibre Free fed mice [1.7] [#Eubacterium rectale] - EEN feeding, mucus erosion still occurs but is offset by #Isobutyrate production. - #Isobutyrate production is both influenced by diet and contingent upon E. rectale. [#sIgA] - IgAs are among the most abundant proteins in mucus. - Their secretion is a key anti-microbial mechanism, and IgA coating has been proposed to identify bacteria that are potentially more colitogenic. - fiber deprivation initiates early disruptions in IgA-microbiota interactions along with a loss of IgA-producing plasma cells.References Notes[ ]
