Parabacteroides ⇒ Parabacteroides distasonis {10000226}

Shared Reference Notes

• [1.1] 
  - P. distasonis > negatively associated with celiac disease. - P. distasonis > reduce weight gain, hyperglycemia, and liver steatosis in ob/ob and high-fat diet mice > significantly reduce the severity of intestinal inflammation in murine models of acute and chronic colitis
• [1.2] [#Diabetes Type 1] 
  - The #hprt4–18 peptide produced by bacterium Parabacteroides distasonis mimics an important insulin epitope (insB:9-23). Human and mouse immune cells specific to insB:9-23 cross-react with this bacterial mimic. Further, P. distasonis can accelerate diabetes onset in a mouse model of T1D, inducing destructive immune cells and decreasing protective immune cells. - Seroconversion rates (i.e., the proportion of individuals developing two or more autoantibodies) were consistently higher in children whose microbiome harbored sequences capable of producing the #hprt4–18 peptide compared to individuals who did not harbor it.
• [1.3] [#Oleic acid, #Stearic acid] 
  - mice with severe #Psoriasis-like skin phenotype exacerbated psoriasiform skin inflammation in mice with mild symptoms > increased the abundance of #Prevotella, while decreasing that of Parabacteroides distasonis, in the colon > increasing the abundance of oleic and stearic acids.
• [1.4] [#Chronic fatigue syndrome] 
  - In ME/CFS without IBS, decreased #Tyrosine correlated with decreased P. distasonis.
• [1.5] 
  - Parabacteroides distasonis and #Akkermansia muciniphila have the highest PS for producing #Propionate through the fermentation of #Pyruvate.
• [1.6] [#Rheumatoid Arthritis] 
  - The relative abundance of P. distasonis in new-onset patients with RA and patients with RA with history of the disease was downregulated and this decrease was negatively correlated with Disease Activity Score-28 (DAS28)
• [#Rheumatoid Arthritis] - Oral treatment of arthritic mice with live P. distasonis (LPD) considerably ameliorated RA pathogenesis. - LPD-derived #Lithocholic acid (LCA), #Deoxycholic acid (DCA), #Isolithocholic acid (isoLCA) and #3-oxolithocholic acid (3-oxoLCA) had similar and synergistic effects on the treatment of RA. - A specific synthetic inhibitor of bile salt hydrolase attenuated the antiarthritic effects of LPD by reducing the production of these four bile acids.
• [1.7] [#TNF-alfa] 
  - oral administration of Parabacteroides distasonis could reduce the production of TNF-α
• [1.8] 
  - members of the genus #Parabacteroides including #Parabacteroides distasonis were previously found to be decreased in #Autoimmune disease
• [1.9] [#Osteopontin] [#Human breast milk, #Infants] 
  - #Lactalbumin at 42 days, > positively correlated with P. distasonis. - #Lactalbumin have pointed to improved early immunity and intestinal mucosal barrier. - #Lactalbumin and OPN might jointly affect P. distasonis early in life to regulate infant immunity.
• - P. distasonis is associated with increased expression of the tight junction protein #Occludin, indicating that this species plays a protective role in the maintenance of the intestinal epithelial
• [#Osteopontin] [#Human breast milk] - the breast milk OPN content was positively correlated with the abundance of P. distasonis > maintaining and protecting intestinal health and the gut barrier. - the effects of early breast milk OPN may last for several months, as there was still a positive correlation between the breast milk OPN content at 42 days and P. distasonis at 3 months
• - P. distasonis is recurrent in #Crohn’s disease and elevated in #Ankylosing spondylitis (AS).
• [#Autoimmune disease] - P. distasonis , along with #Prevotella copri, increased IFN-gamma-producing cells, possibly a trigger for auto-immunity, and mouse models suggest that P. distasonis may be proinflammatory, activating pathogenic toxins and contributing to #Reactive Oxygen Species via catalase production.
• [#Juvenile idiopathic arthritis] [#Human breast milk] - taxa associated with ABIS JIA had a significant association with shorter durations of breastfeeding, including #Acidaminococcales, #Prevotella 9, Parabacteroides distasonis, and several ASVs belonging to #Bacteroides, #Veillonella parvula, #Turicibacter sanguinis, #Eggerthella lenta, and P. distasonis.
• [#Juvenile idiopathic arthritis] - In ABIS, Parabacteroides distasonis in stool at one year was associated with 6.7-increased odds of later contracting JIA (9.0-increased odds after propensity matching).
• - P. distasonis fermentation could result in the production of #Methane, which has been shown to reduce ileal motility and contribute to the pathogenesis of intestinal disorders.
• [1.11] [#Bacteroides uniformis, #Escherichia coli, #Faecalibacterium prausnitzii] [#Fasting] 
  - During IER > the abundance of #Obesity-related probiotics including F. prausnitzii, P. distasonis, and B. uniformis significantly increased compared with that at baseline, whereas the abundance of pathogenic E. coli significantly decreased. - the reduction in E.coli abundance sustained to the endpoint of phase III, whereas the abundance of F. prausnitzii, P. distasonis, and B. uniformis peaked at midpoint of phase II and declined to near baseline levels at endpoint of phase III.
• [#Bacteroides uniformis, #Faecalibacterium prausnitzii] - F. prausnitzii, P. distasonis, and B. uniformis can reduce #Obesity and alleviate #Obesity-related metabolic and immune disorders
• [1.12] 
  - Parabacteroides distasonis alleviates #Obesity and metabolic dysfunctions via production of #Succinate and #Secondary bile acids. - Administration of Parabacteroides distasonis leads to increased bile salt hydrolase (BSH) activity, inhibition of intestinal FXR signaling and decreased TCDCA levels in liver
• [1.13] 
  - #Akkermansia muciniphila and Parabacteroides distasonis were significantly increased in the microbiota of resistant mice. - A. muciniphila and P. distasonis synergistically drive a protective effect in both acute and chronic models of #Colitis by boosting the frequency of type 3 innate lymphoid cells in the colon and by improving gut epithelial integrity.

References Notes